背景:细胞衰老与年龄相关的病理变化有关,衰老细胞促进膝骨关节炎的发展。对膝骨关节炎和细胞衰老之间的更好理解可能会增强旨在减缓或阻止该疾病进展的疗法的有效性。目的:本研究旨在系统分析和可视化出版趋势,用文献计量学方法研究膝关节骨性关节炎与细胞衰老的研究前沿和当前研究热点。方法:在WebofScienceCoreCollection数据库上进行出版物搜索,查找1992年至2023年出版的文献。VOSviewer,城市空间,使用R包Bibliometrix和MicrosoftOfficeExcel来研究出版物的特征。出版物编号,国家,机构,作者,期刊,引文和共同引文,关键词进行了分析。结果:共分析1074篇出版物,年平均增长率为29.89%。美国是最大的贡献者,在出版物和引文中排名第一。这一领域的出版物发表在420种期刊上,骨关节炎和软骨是最具影响力的。共有5,657位作者为这项研究做出了贡献。最有成效的作者是Lotz,MK(n=31,H指数=22,总引文=2,619),紧随其后的是Loeser,R.F(n=16,H指数=14,总引文=2,825)。然而,作者之间的合作相对薄弱。在涉及的1556个机构中,60%来自美国。ScrippsResearch以25篇论文和2,538篇引用次数排名第一。这一领域的热点集中在病理机制上(例如,表达式,炎症,凋亡,自噬,氧化应激)和治疗学(例如,干细胞,富血小板血浆,移植,自体软骨细胞,repair),Senolyics的探索可能是未来研究的重要方向。结论:膝关节骨性关节炎与细胞衰老的交叉领域研究正在蓬勃发展。关节中各种细胞的年龄相关病理机制图和衰老细胞的靶向药物可能是未来的趋势。这项文献计量学研究提供了对这一交叉领域的全面分析和对未来研究的新见解。
Background: Cellular senescence is associated with age-related pathological changes, senescent cells promote the development of knee osteoarthritis. A better understanding between knee osteoarthritis and cellular senescence may enhance the effectiveness of therapies that aim to slow or stop the progression of this disease. Purpose: This study aimed to systematically analyze and visualize the publication trends, research frontiers and current research hotspots of knee osteoarthritis and cellular senescence by using bibliometrics. Methods: The publication search was performed on the Web of Science Core Collection database for documents published from 1992 to 2023. VOSviewer, Citespace, R package Bibliometrix and Microsoft Office Excel were used to study the characteristics of the publications. The publication number, countries, institutions, authors, journals, citations and co-citations, keywords were analyzed. Results: A total of 1,074 publications were analyzed, with an average annual growth rate of 29.89%. United States accounted for the biggest contributor, ranked first in publications and citations. Publications of this field were published in 420 journals, OSTEOARTHRITIS and CARTILAGE was the most influential. A total of 5,657 authors contributed to this research. The most productive author was Lotz, MK (n = 31, H-index = 22, Total citation = 2,619), followed by Loeser, R.F (n = 16, H-index = 14, Total citation = 2,825). However, the collaboration between authors was relatively weak. Out of the 1,556 institutions involved, 60% were from the United States. Scripps Research ranked first with 25 papers and a total of 2,538 citations. The hotspots of this field had focused on the pathomechanisms (e.g., expression, inflammation, apoptosis, autophagy, oxidative stress) and therapeutics (e.g., stem cell, platelet-rich plasma, transplantation, autologous chondrocytes, repair), and the exploration of Senolytics might be the important direction of future research. Conclusion: Research on the cross field of knee osteoarthritis and cellular senescence is flourishing. Age-related pathomechanism maps of various cells in the joint and the targeted medicines for the senescent cells may be the future trends. This bibliometric study provides a comprehensive analysis of this cross field and new insights into future research.