背景:人类和动物研究的最新研究证实,认知训练对轻度认知障碍的老年人的多个认知领域有相当大的影响。以往的研究还很少关注执行功能训练。对于这种特定的好处是否会转化为保持长期有效性和转移效应,人们知之甚少。本研究旨在解决这一问题。
目的:该计划旨在评估基于过程的多任务认知训练对执行功能的影响,并进一步探讨其在MCI老年人中的长期影响和转移效应。此外,我们将探索潜在的神经相关性,潜在的认知干预的变化表现。
方法:这个程序是单盲的,随机化,前瞻性临床试验,以测试基于过程的多任务认知训练对MCI老年人的影响。90名MCI参与者将被招募并随机分配到认知训练组(n=45)和等待名单对照组(n=45)。认知训练组将每周两次接受为期10周的基于过程的多任务认知训练和健康教育,每次40~60分钟。而等待名单对照组在研究期间只会接受10周的健康教育。效果是用执行功能来衡量的,在基线时使用脑电图参数(EEG的缓慢和复杂性)评估神经心理学评估表现和相关的大脑活动,经过10周的训练,和3个月的随访。
结果:该研究目前正在进行中。招聘始于2019年3月,将于2020年底结束。基于过程的多任务认知训练对MCI老年人执行功能的影响将在意向治疗分析和协议集原则中进行描述。我们还将探讨潜在的长期影响和转移效应。
结论:如果基于过程的多任务认知训练计划导致MCI老年人的执行功能发生积极变化,这可能提供一种可行和潜在的方法来延缓认知能力下降。临床试验注册:ChiCTR1900020585。2019年1月9日注册。http://www。chictr.org.cn/showproj.aspx?proj=34664。
BACKGROUND: Recent research from both human and animal studies confirms that cognitive training gains a considerable effect on multiple cognitive domains in older adults with mild cognitive impairment. Previous studies have yet paid scant attention to executive function training. Little is known about whether this specific benefit translates to maintaining long-term effectiveness and transfer effects are. This study is designed as an effort to address this issue.
OBJECTIVE: The program aimed to evaluate the effect of process-based multi-task cognitive training on executive function and further explore its long-term effects and transfer effects in older adults with MCI. Furthermore, we will explore the neural correlates latent the changed performances underlying the cognitive intervention.
METHODS: This program is a single-blinded, randomized, prospective clinical trial to test the effect of process-based multi-task cognitive training in older adults with MCI. Ninety participants with MCI will be recruited and randomly assigned to the cognitive training group (n=45) and the wait-list control group (n=45). The cognitive training group will receive 10 weeks of process-based multi-task cognitive training and health education twice a week, at 40~60 min per session. While the wait-list control group will only receive 10 weeks of health education during the research period. The effect is measured using the executive function, neuropsychological assessment performance and related brain activity assessed with electroencephalogram parameters (slowness and complexity of the EEG) at baseline, after 10 weeks of training, and a 3-month follow-up.
RESULTS: The study is currently ongoing. Recruitment began in March 2019 and will conclude at the end of 2020. Effects of the process-based multi-task cognitive training on executive function in older adults with MCI will be described in intention-to-treat analysis and protocol set principle. We will also explore the potential long-term effects and transfer effects.
CONCLUSIONS: If a process-based multi-task cognitive training program results in positive changes to executive function in older adults with MCI, this might provide a viable and potential approach to delay the cognitive decline. Clinical Trial Registration: ChiCTR1900020585. Registered on January 09, 2019. http://www.chictr.org.cn/showproj.aspx?proj=34664.