背景:先前的研究已经通过实验验证并报道了海洋海绵的化学成分是天然抗炎物质的来源,具有开发新药的生物技术潜力。
目标:因此,本研究的目的是进行系统评价,以概述从海洋海绵中分离出的具有治疗潜力的抗炎物质.
方法:本系统综述是在Embase,PubMed,Scopus和WebofScience电子数据库。总的来说,发现613人,但排除了340项重复研究,只有100份手稿是合格的,83人包括在内。
结果:结果基于体内和体外测定,研究了从海洋海绵中提取的251种生物活性化合物的抗炎作用。它们的抗炎活性包括抑制促炎介质,如肿瘤坏死因子-α(TNF-α),白细胞介素-6(IL-6),亚硝酸盐或一氧化氮(NO),诱导型一氧化氮合酶(iNOS),环氧合酶-2(COX-2),白细胞介素1β(IL-1β),前列腺素E2(PGE2),磷脂酶A2(PLA2),核转录因子-κB(NF-κB),白三烯B4(LTB4),cy-环氧合酶-1(COX-1),和超氧化物自由基。
结论:结论:数据表明(大约98%的文章),从海洋海绵中获得的物质可能有望用于开发用于治疗不同病理状况的新型抗炎药物。
BACKGROUND: Previous studies have experimentally validated and reported that chemical constituents of marine sponges are a source of natural anti-inflammatory substances with the biotechnological potential to develop novel drugs.
OBJECTIVE: Therefore, the aim of this study was to perform a systematic review to provide an overview of the anti-inflammatory substances isolated from marine sponges with therapeutic potential.
METHODS: This systematic review was performed on the Embase, PubMed, Scopus and Web of Science electronic databases. In total, 613 were found, but 340 duplicate studies were excluded, only 100 manuscripts were eligible, and 83 were included.
RESULTS: The results were based on in vivo and in vitro assays, and the anti-inflammatory effects of 251 bioactive compounds extracted from marine sponges were investigated. Their anti-inflammatory activities include inhibition of pro-inflammatory mediators, such as tumor necrosis factor- α (TNF-α), interleukin-6 (IL-6), nitrite or nitric oxide (NO), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin 1β (IL-1β), prostaglandin E2 (PGE2), phospholipase A2 (PLA2), nuclear transcription factor-kappa B (NF-κB), leukotriene B4 (LTB4), cyclooxygenase- 1 (COX-1), and superoxide radicals.
CONCLUSIONS: In conclusion, data suggest (approximately 98% of articles) that substances obtained from marine sponges may be promising for the development of novel anti-inflammatory drugs for the treatment of different pathological conditions.