背景:痤疮病理生理学包括炎症介质之间的复杂相互作用,脂溢过多,痤疮丙酸杆菌改变角质化和卵泡定植。
目的:描述曝光对痤疮的影响以及光保护如何改善结果。
方法:对文献进行了叙述性回顾;从1992年1月至2022年11月,使用GoogleScholar和Pubmed进行了搜索。使用的关键词是“痤疮,\"\"防晒霜,\"\"光保护,\“\”化妆品,\"\"药妆,“”发病机理,“病因学”,\"\"暴露,\"\"阳光,\"\"压力,\"\"睡眠不足,\"\"饮食,炎症后色素沉着,\"\"污染,\"\"暴露,紫外线辐射,\"和\"可见光。\"
结果:环境因素,如太阳辐射,空气污染,烟草消费,心理压力,不同的微生物,营养,其中,可以触发或恶化痤疮。太阳辐射可以暂时改善病变。然而,它可以诱导促炎和促纤维化反应,并产生炎症后色素沉着过度和/或炎症后红斑。虽然光保护被广泛推荐给痤疮患者,只有四项相关研究被发现。防晒霜可以显着改善症状或增强治疗,并可以防止炎症后色素沉着过度。此外,他们可以提供伪装和提高生活质量。基于痤疮的发病机制,最佳防晒霜应该有润肤剂,抗氧化剂和皮脂控制特性。
结论:暴露和太阳辐射可以引发或加重痤疮。紫外线可以诱导炎症后色素沉着/红斑,可以发射耀斑。使用专门配制的防晒剂可以增强对局部或全身治疗的依从性,伪装损伤(有色防晒霜),减少炎症,并降低炎症后色素沉着/红斑的发生率。
BACKGROUND: Acne pathophysiology includes a complex interaction among inflammatory mediators, hyperseborrhea, alteration of keratinization and follicular colonization by Propionibacterium acnes.
OBJECTIVE: To describe the impact of the exposome on acne and how photoprotection can improve outcomes.
METHODS: A narrative review of the literature was carried out; searches with Google Scholar and Pubmed from January 1992 to November 2022 were performed. The keywords used were \"acne,\" \"sunscreens,\" \"photoprotection,\" \"cosmetics,\" \"cosmeceuticals,\" \"pathogenesis,\" \"etiology,\" \"exposome,\" \"sunlight,\" \"stress,\" \"lack of sleep,\" \"diet,\" \"postinflammatory hyperpigmentation,\" \"pollution,\" \"exposome,\" \"ultraviolet radiation,\" and \"visible light.\"
RESULTS: Environmental factors such as solar radiation, air pollution, tobacco consumption, psychological stress, diverse microorganisms, nutrition, among others, can trigger or worsen acne. Solar radiation can temporarily improve lesions. However, it can induce proinflammatory and profibrotic responses, and produce post-inflammatory hyperpigmentation and/or post-inflammatory erythema. While photoprotection is widely recommended to acne patients, only four relevant studies were found. Sunscreens can significantly improve symptomatology or enhance treatment and can prevent post-inflammatory hyperpigmentation. Furthermore, they can provide camouflage and improve quality of life. Based on acne pathogenesis, optimal sunscreens should have emollient, antioxidant and sebum controlling properties.
CONCLUSIONS: The exposome and solar radiation can trigger or worsen acne. UV light can induce post-inflammatory hyperpigmentation/erythema, and can initiate flares. The use of specifically formulated sunscreens could enhance adherence to topical or systemic therapy, camouflage lesions (tinted sunscreens), decrease inflammation, and reduce the incidence of post-inflammatory hyperpigmentation/erythema.