Abstract：
Since the introduction of selective photothermolysis, Q-switched nanosecond lasers have been used for the treatment of dermal pigmented lesions. Over the past several years, picosecond lasers have been introduced to the cosmetic community. We recently performed a study comparing a 550 picosecond 755 nm laser versus a 50 ns 755 nm laser, with the purpose of evaluating the clinical efficacy and complications of each laser when treating nevus of Ota. Ten Asian patients with nevus of Ota were enrolled in the study. Each lesion was split into 2 parts, and patients were treated with a 755 nm picosecond laser (PSL) and a 755 nm nanosecond laser (NSL). The clinical endpoint for fluence choice was immediate whitening (PSL: 2.33 ~ 3.36 J/cm2, NSL: 5.5 ~ 7 J/cm2) of the treated area. The pulse duration was fixed at 550 picoseconds (PSL) and 50 ns (NSL). The spot size of each laser was 2.5-3 mm. Laser treatments were performed until excellent clinical improvement was observed. Patients were examined 1 week after the first treatment, at each follow-up visit, and 6 months after the last laser treatment. The average number of treatment sessions to achieve excellent clinical improvement was 4.2 treatments using PSL and 5.4 treatments using NSL. One case of hyperpigmentation and one case of hypopigmentation were observed in the NSL treatment group. There were no complications in the PSL treatment group. The 755 nm 550 picosecond laser is significantly more effective than the 755 nm 50 ns laser in the treatment of nevus of Ota. The PSL treatment group also had minimum side effects.
摘要：
由于引入了选择性光热解，Q开关纳秒激光器已用于治疗皮肤色素沉着病变。在过去的几年里，皮秒激光器已被引入化妆品界。我们最近进行了一项研究，比较550皮秒755nm激光与50ns755nm激光，目的是评估每种激光治疗太田痣的临床疗效和并发症。10名患有太田痣的亚洲患者被纳入研究。每个病灶分成两部分,患者接受755nm皮秒激光（PSL）和755nm纳秒激光（NSL）治疗。注量选择的临床终点是治疗区域的立即增白(PSL:2.33~3.36J/cm2,NSL:5.5~7J/cm2)。脉冲持续时间固定在550皮秒(PSL)和50ns(NSL)。每个激光器的光斑尺寸为2.5-3mm。进行激光治疗直至观察到良好的临床改善。第一次治疗后1周检查患者，在每次后续访问中，最后一次激光治疗后6个月。实现优异的临床改善的治疗疗程的平均数目是使用PSL的4.2治疗和使用NSL的5.4治疗。在NSL治疗组中观察到1例色素沉着过度和1例色素沉着不足。PSL治疗组无并发症发生。在Ota痣的治疗中，755nm550皮秒激光明显比755nm50ns激光更有效。PSL治疗组的副作用也最小。
