背景:目前尚不清楚COVID-19病后(PCC)认知功能的主观和客观指标是否相关。相关性的程度具有机制和临床意义。
方法:这是对随机,双盲,安慰剂对照临床试验包含在一个严格表征的PCC患者队列中认知主观和客观测量的基线数据.在这里,我们评估了主客观条件函数之间的关联,根据感知赤字问卷的衡量,20项(PDQ-20)和数字符号替换测试(DSST)和轨迹制作测试(TMT)-A/B,分别。
结果:共有152名参与者组成基线样本。由于缺少数据,我们的统计分析包括150名自我报告的PDQ-20,147名合并DSST测量的认知功能的个体(Pen/Paper的复合z得分加上在线CogState版本,NcombinedDSST),71人DSST测量的认知功能(笔/纸版),70对于TMT-A测量的认知功能,TMT-B测量的认知功能为70。在调整了年龄之后,性别,和教育,PDQ-20与纸笔DSST(β=-0.003,p=0.002)和TMT-B(β=0.003,p=0.008)评分显著相关,但与TMT-A评分无关(β=-0.001,p=0.751)。
结论:总体而言,在主观和客观认知功能之间观察到统计学上显著的相关性.为有主观认知功能投诉的PCC患者提供护理的临床医生可以考虑在护理点采取基于测量的认知方法,该方法仅关注患者报告的措施。
BACKGROUND: It remains unclear whether subjective and objective measures of cognitive function in Post COVID-19 Condition (PCC) are correlated. The extent of correlation has mechanistic and clinical implications.
METHODS: This post-hoc analysis of a randomized, double-blind, placebo-controlled clinical trial contains baseline data of subjective and objective measures of cognition in a rigorously characterized cohort living with PCC. Herein, we evaluated the association between subjective and objective condition function, as measured by the Perceived Deficits Questionnaire, 20-item (PDQ-20) and the Digit Symbol Substitution Test (DSST) and Trails Making Test (TMT)-A/B, respectively.
RESULTS: A total of 152 participants comprised the baseline sample. Due to missing data, our statistical analyses included 150 for self-reported PDQ-20, 147 individuals for combined DSST-measured cognitive function (composite z-score of the Pen/Paper plus Online CogState Version, NcombinedDSST), 71 for in-person DSST-measured cognitive function (Pen/Paper Version), 70 for TMT-A-measured cognitive function, and 70 for TMT-B-measured cognitive function. After adjusting for age, sex, and education, PDQ-20 was significantly correlated with pen-and-paper DSST (β = -0.003, p = 0.002) and TMT-B (β = 0.003, p = 0.008) scores, but not with TMT-A scores (β = -0.001, p = 0.751).
CONCLUSIONS: Overall, a statistically significant correlation was observed between subjective and objective cognitive functions. Clinicians providing care for individuals with PCC who have subjective cognitive function complaints may consider taking a measurement-based approach to cognition at the point of care that focuses exclusively on patient-reported measures.