在过去,聚丙烯酰胺水凝胶是隆胸填充剂的热门选择,许多女性用这种凝胶进行了乳房成形术。然而,由于频繁的并发症,聚丙烯酰胺水凝胶在乳房成形术中的使用已被禁止。尽管有这个禁令,出现并发症的患者仍在寻求治疗。这项研究的目的是研究聚合物在确定的植入期内的命运。乳房植入物的活检来自乳房成形术后23年和27年的患者。这些活检从生物杂质中精心纯化,并使用红外光谱法进行分析,液相色谱-质谱,气相色谱法,和差示扫描量热法。研究结果揭示了聚丙烯酰胺水凝胶残留物的存在,连同降解产物,在受感染的材料中。值得注意的是,通过气相色谱法显示的低分子量降解产物是能够诱导慢性炎症的侵袭性和毒性物质。本研究揭示了聚丙烯酰胺水凝胶植入的长期后果,强调有害降解产物的持久性及其在加剧患者并发症中的作用。
In the past,
polyacrylamide hydrogel was a popular choice for breast augmentation filler, and many women underwent mammoplasty with this gel. However, due to frequent complications, the use of
polyacrylamide hydrogel in mammoplasty has been banned. Despite this ban, patients experiencing complications still seek medical treatment. The aim of this study was to investigate the fate of the polymer over a defined implantation period. Biopsies of breast implants were obtained from patients with 23 and 27 years of post-mammoplasty. These biopsies were meticulously purified from biological impurities and subjected to analysis using IR spectrometry, liquid chromatography-mass spectrometry, gas chromatography, and differential scanning calorimetry. The findings revealed the presence of
polyacrylamide hydrogel residues, along with degradation products, within the infected material. Notably, the low-molecular-weight degradation products revealed via gas chromatography are aggressive and toxic substances capable of inducing chronic inflammation. This study sheds light on the long-term consequences of
polyacrylamide hydrogel implantation, highlighting the persistence of harmful degradation products and their role in exacerbating patient complications.