Abstract：
Controlled drug delivery systems offer numerous advantages. This research evaluates Opuntia leaf mucilage grafted with polyacrylamide (OPM-g-PAM) as a promising controlled-release polymer. PAM chains were grafted onto the backbone of OPM using a microwave-assisted method. Optimization of the best grade was based on % grafting efficiency and intrinsic viscosity, followed by extensive physical and analytical characterizations. Analytical characterizations revealed semicrystalline nature of the biomaterial. SEM and AFM observations revealed rough and porous surfaces, indicating effective grafting. Swelling behavior showed maximum sensitivity at pH 7, with reduced swelling at higher sodium chloride concentrations. A comparative study of % drug release of Rosuvastatin over 24 h showed that the optimized grade controlled drug release effectively, achieving 78.5 % release compared to 98.8 % for GF-3. The release data fitted the Korsmeyer-Peppas model, with an \"n\" value of 0.8334, indicating non-Fickian (anomalous) diffusion. Bacterial biodegradability studies confirmed the high biodegradability of the graft copolymer. In vitro acute toxicity tests showed no toxicity, as confirmed by histopathological studies of heart, liver, and kidney. Overall, the results indicate that OPM-g-PAM is a highly promising material for use in drug delivery systems, demonstrating potential as a novel controlled-release polymer.
摘要：
受控药物递送系统提供许多优点。这项研究评估了接枝聚丙烯酰胺（OPM-g-PAM）作为有前途的控释聚合物的仙人掌叶粘液。使用微波辅助方法将PAM链接枝到OPM的主链上。最佳等级的优化是基于%接枝效率和特性粘度，其次是广泛的物理和分析特征。分析表征揭示了生物材料的半结晶性质。SEM和AFM观察显示粗糙和多孔表面，表明有效的嫁接。溶胀行为在pH7时显示出最大的敏感性，在较高的氯化钠浓度下溶胀降低。瑞舒伐他汀24h释药%的对比研究表明,优化后的药物释放量,实现78.5%的释放，而GF-3为98.8%。发布数据符合Korsmeyer-Peppas模型，“n”值为0.8334，表示非Fickian(异常)扩散。细菌生物降解性研究证实了接枝共聚物的高生物降解性。体外急性毒性试验显示无毒性，心脏组织病理学研究证实，肝脏,还有肾.总的来说,结果表明，OPM-g-PAM是一种非常有前途的用于药物输送系统的材料，展示了作为新型控释聚合物的潜力。
