Significant volumes of agricultural and industrial waste are produced annually. With the global focus shifting towards sustainable and environmentally friendly practices, there is growing emphasis on recycling and utilizing materials derived from such waste, such as cellulose and lignin. In response to this imperative situation, nanocellulose materials have surfaced attracting heightened attention and research interest owing to their superior properties in terms of strength, stiffness, biodegradability, and water resistance. The current manuscript provided a comprehensive review encompassing the resources of nanocellulose, detailed pretreatment and extraction methods, and present applications of nanocellulose. More importantly, it highlighted the challenges related to its processing and utilization, along with potential solutions. After evaluating the benefits and drawbacks of different methods for producing nanocellulose, ultrasound combined with acid hydrolysis emerges as the most promising approach for large-scale production. While nanocellulose has established applications in water treatment, its potential within the food industry appears even more encouraging. Despite the numerous potential applications across various sectors, challenges persist regarding its modification, characterization, industrial-scale manufacturing, and regulatory policies. Overcoming these obstacles requires the development of new technologies and assessment tools aligned with policy. In essence, nanocellulose presents itself as an eco-friendly material with extensive application possibilities, prompting the need for additional research into its extraction, application suitability, and performance enhancement. This review focused on the wide application scenarios of nanocellulose, the challenges of nanocellulose application, and the possible solutions.

Migration policies have a significant impact on population health, particularly for individuals living with human immunodeficiency virus (HIV). These policies not only determine who is allowed to enter a country but also influence which immigrants can access services provided by the government. Some countries continue to impose restrictions on HIV-positive individuals, justifying these measures as necessary to protect public health and mitigate healthcare and economic concerns. However, these restrictions lack a valid public health rationale. Due to social, economic and political constraints, restrictive migration laws hinder access to HIV prevention, care and treatment services for immigrants living with HIV. Immigrants face numerous challenges in accessing medication, adhering to treatment regimens and benefitting from HIV preventive efforts. This situation increases the risk of HIV infection and adverse health outcomes due to limited access to preventive programmes, social stigma and engagement in risky behaviours. Additionally, these restrictive migration rules negatively affect immigrants\' mental health. To improve the health of both immigrants and host communities, inclusive and evidence-based migration policies that address healthcare through public health and human rights lenses are required.

Cooperative green technology innovation is potentially the answer to the lack of motivation for independent green innovation, which can effectively alleviate many difficulties faced by enterprises engaging in independent green innovation. Internet development provides new opportunities to stimulate innovative cooperation of enterprises. However, little literature has studied the impact of Internet development on enterprises\' cooperative green technology innovation. Based on the data of Chinese A-share 3284 listed companies from 2010 to 2019, this paper uses a panel two-way fixed effects model to assess the effect of Internet development on enterprises\' cooperative green innovation. The findings are: (1) Internet development significantly drives firms\' collaborative green innovation behavior. The result remains robust even after performing a series of robust tests. (2) The Internet empowers green innovation cooperation among firms by improving information availability, including market information availability and technical information availability. (3) The heterogeneous results show enterprises use the Internet to accomplish high-quality collaborative green innovation. Internet development is more helpful in encouraging the cooperative green innovation of enterprises located in central cities and state-owned enterprises. This study provides novel and targeted policy implications to empower enterprises\' green innovation cooperation and drive sustainable economic development through Internet development.

One Health is an interdisciplinary approach that promotes the resolution of complex health issues through collaboration across multiple disciplines. In addition to accountability, the One Health governance structure fosters shared understanding, trust, and an appreciation for diverse perspectives and requirements. This article provides a comprehensive analysis of the current integration of the One Health approach within China\'s existing health governance framework. It also proposes strategies for further improvement, with emphasis on the level of implementation and contributions to the advancement of One Health governance through an examination of current health policies.

The triple crises of the COVID-19 pandemic, conflict and climate change have severely impacted food systems, leading to socio-economic consequences and undermining food and nutrition security across Africa. To address the malnutrition and poverty affecting approximately 700 million people in Africa, there is potential for the One Health approach implementation and operationalization to bring together multidisciplinary solutions for tackling food insecurity and ensuring food safety net. However, there is limited documentation on the potential of the One Health approach system thinking implementation to guide responses to triple crises-induced food insecurity. Therefore, this article aims to systematically understand the triple crises-induced food insecurity, connect existing solutions, and explore the role of the One Health approach in strengthening food and agriculture systems in Africa. Our finding showed the impact of triple crises exacerbating food system vulnerability in Africa and worldwide. Mitigating and resilient actions are urgently needed in tackling the emerging and persisting challenges, and infectious diseases menace and burden across Africa. We present a conceptual model illustrating the complex nature of triple crises-induced food insecurity, vulnerability areas within the food system, and actionable strategies for building community food resilience. Additionally, recommendations are provided to create an enabling environment that supports One Health approach implementation and addresses food insecurity challenges through innovative partnerships, local-led initiatives, and enhanced governance and artificial intelligence technology capacities in achieving sustainable and inclusive growth to reduce socio-economic inequalities. Stepping up integrated, actionable, and sustainable food systems programs and innovative long-lasting solutions requires investing in promoting new partnership and research collaboration in building conflict resolution and peace towards strengthening and reshaping local and global food security related climate change adaptations actions for most vulnerable communities\' benefits. These are ingredients in fastening preparedness, prevention and control of infectious diseases prevention and control, reducing food supply chains disruption towards accelerating equitable benefits of Universal Health Coverage and Sustainable Development Goals, 2030 across Africa.

BACKGROUND: The first agent of socialisation is the family, who are expected to facilitate the inclusion of children in societal activities. While mothers\' voices have been widely captured in the literature regarding their experiences raising children with disabilities, fathers\' perceptions of their knowledge of and involvement in the development of children with disabilities have been understudied, particularly in non-Western contexts.
OBJECTIVE: The main aim of this study was to examine fathers\' perceptions of their involvement in raising children with disabilities in the United Arab Emirates.
METHODS: In total, 469 fathers were recruited to understand their involvement in raising their children with disabilities. The Fathers\' Involvement in Development and Rehabilitation Scale was used to collect data, which were analysed using SPSS and AMOS.
RESULTS: The results showed that fathers rated themselves highly for their attitudes, support, and participation in training to support their children with disabilities. Demographic variables, such as nationality and educational qualifications, provided additional insight into their involvement in raising their children with disabilities.
CONCLUSIONS: The study concludes with suggestions for training programmes to change fathers\' attitudes towards children with disabilities, as such programmes can enable them to better support their children\'s development.

BACKGROUND: Artificial intelligence (AI) holds immense potential for enhancing clinical and administrative health care tasks. However, slow adoption and implementation challenges highlight the need to consider how humans can effectively collaborate with AI within broader socio-technical systems in health care.
OBJECTIVE: In the example of intensive care units (ICUs), we compare data scientists\' and clinicians\' assessments of the optimal utilization of human and AI capabilities by determining suitable levels of human-AI teaming for safely and meaningfully augmenting or automating 6 core tasks. The goal is to provide actionable recommendations for policy makers and health care practitioners regarding AI design and implementation.
METHODS: In this multimethod study, we combine a systematic task analysis across 6 ICUs with an international Delphi survey involving 19 health data scientists from the industry and academia and 61 ICU clinicians (25 physicians and 36 nurses) to define and assess optimal levels of human-AI teaming (level 1=no performance benefits; level 2=AI augments human performance; level 3=humans augment AI performance; level 4=AI performs without human input). Stakeholder groups also considered ethical and social implications.
RESULTS: Both stakeholder groups chose level 2 and 3 human-AI teaming for 4 out of 6 core tasks in the ICU. For one task (monitoring), level 4 was the preferred design choice. For the task of patient interactions, both data scientists and clinicians agreed that AI should not be used regardless of technological feasibility due to the importance of the physician-patient and nurse-patient relationship and ethical concerns. Human-AI design choices rely on interpretability, predictability, and control over AI systems. If these conditions are not met and AI performs below human-level reliability, a reduction to level 1 or shifting accountability away from human end users is advised. If AI performs at or beyond human-level reliability and these conditions are not met, shifting to level 4 automation should be considered to ensure safe and efficient human-AI teaming.
CONCLUSIONS: By considering the sociotechnical system and determining appropriate levels of human-AI teaming, our study showcases the potential for improving the safety and effectiveness of AI usage in ICUs and broader health care settings. Regulatory measures should prioritize interpretability, predictability, and control if clinicians hold full accountability. Ethical and social implications must be carefully evaluated to ensure effective collaboration between humans and AI, particularly considering the most recent advancements in generative AI.

South Africa is considered a food-secure nation; however, food insecurity is still a major challenge for many poor rural households that rely on cash incomes and government grants for survival. Furthermore, these grants are not always adequate to meet households\' basic needs, and fail to provide them with the food required for food and nutrition security. Some of these households rely on agriculture to supplement their food needs, and an important aspect of this agricultural production is the seed system. Smallholder farmers in rural areas rely on informal seed systems, and use traditional knowledge and methods to produce, harvest, store, and sell their produce. This research combined quantitative and qualitative methods to assess the role of informal seed systems in promoting food production in rural smallholder agricultural households in South Africa. The narrative review showed reword that while smallholder farmers acquire seed from informal seed systems, they face numerous challenges that affect their production activities. These challenges include poor seed quality and assessment, poor storage and harvesting facilities, which limit proper seed production, and affect crop yield and marketing. Due to these challenges, the ability of rural smallholder farmers to access mainstream markets is limited and as a result, they are confined to local markets that offer lower prices. Moreover, South African policies do not recognize the informal seed system as one of the contributors to food security. This is a major limitation as farmers may not receive the support and assistance they require. Formal recognition and support for informal seed systems would go a long way in improving smallholder farmers\' access to quality seed. This would have ripple effects on their yields and productivity. When properly implemented and given recognition by the government, informal seed systems have the potential to contribute to rural food security and livelihoods.

Rare diseases have various types, low incidence rates, complex conditions, and are often difficult to diagnose. Due to China\'s large population, there is a significant number of rare disease patients, but there is a shortage of orphan drugs. Consequently, these patients often find themselves in a situation where necessary medications are either unavailable or unaffordable. To address this urgent clinical need, China has implemented a series of orphan drug policies aimed at improving drug accessibility and affordability. In terms of drug accessibility, companies are encouraged to expedite drug development through the implementation of tax incentives, guidance for clinical research on rare diseases, and the provision of data protection periods of 6 years, along with market exclusivity periods limited to a maximum of 7 years. Moreover, exemptions for clinical trials, acceptance of overseas clinical trial data, and the creation of a list prioritizing clinically urgent new drugs from overseas have been introduced to expedite the drug registration application, review, inspection, and approval processes. In terms of drug affordability, the import value-added tax on rare disease drugs has been reduced by 3%, and various provinces and cities have established a representative rare disease protection model, which includes special funds, medical assistance programs, and serious disease insurance. The national medical insurance catalog has been adjusted to reduce the financial burden on rare disease patients, resulting in an increase in the number of orphan drugs covered by the catalog to 95 as of March 2024. By comparing orphan drug policies in the United States, the European Union, Japan, Australia, and other countries (or regions), we will provide relevant suggestions to further improve orphan drug policies in China, thus bringing more treatment options and hope to patients with rare diseases.

The challenges of drug development in pediatric, pregnant and geriatric populations are a worldwide concern shared by regulatory authorities, pharmaceutical companies, and healthcare professionals. Model-informed drug development (MIDD) can integrate and quantify real-world data of physiology, pharmacology, and disease processes by using modeling and simulation techniques to facilitate decision-making in drug development. In this article, we reviewed current MIDD policy updates, reflected on the integrity of physiological data used for MIDD and the effects of physiological changes on the drug PK, as well as summarized current MIDD strategies and applications, so as to present the state of the art of MIDD in pediatric, pregnant and geriatric populations. Some considerations are put forth for the future improvements of MIDD including refining regulatory considerations, improving the integrity of physiological data, applying the emerging technologies, and exploring the application of MIDD in new therapies like gene therapies for special populations.