背景:实验研究强调了用于光动力疗法的植物来源的光敏剂的治疗潜力。此外,一些体外和体内研究表明,鲜为人知的蒽醌可以选择性靶向癌细胞并在光照射后消除它们,具有很好的作用。这篇文献综述总结了PDT中选择的基于植物的光敏剂的当前知识,以显示大黄素的结果,芦荟大黄素,Parietin,rubiadin,金丝桃素,和山梨二醇在光动力疗法癌症治疗中的作用,并描述了它们作为天然光敏剂的作用的综合观点。
方法:在PubMed.gov上对所选蒽醌进行文献检索,关键字为:\"大黄素\",“芦荟大黄素”,\"金丝桃素\",\"parietin\",\"rubiadin\",“soranjidiol”与“癌症”和“光动力疗法”。
结果:根据文献数据,这篇综述集中在所有现有的大黄素体外和体内研究,芦荟大黄素,Parietin,rubiadin,山梨二醇用作天然光敏剂,强调其在抗癌治疗中的有效性和详细作用机制。此外,对金丝桃素的全面临床前和临床研究表明,上述物质可能包括在不同癌症的光毒性治疗中。
结论:总体而言,这篇综述介绍了鲜为人知的蒽醌及其有前途的分子作用机制。预计将来它们可以用作癌症治疗中的天然PS以及金丝桃素。
BACKGROUND: Experimental studies emphasize the therapeutic potential of plant-derived photosensitizers used in photodynamic therapy. Moreover, several in vitro and in vivo research present the promising roles of less-known anthraquinones that can selectively target cancer cells and eliminate them after light irradiation. This literature review summarizes the current knowledge of chosen plant-based-photosensitizers in PDT to show the results of emodin, aloe-emodin, parietin, rubiadin, hypericin, and soranjidiol in photodynamic therapy of cancer treatment and describe the comprehensive perspective of their role as natural photosensitizers.
METHODS: Literature searches of chosen anthraquinones were conducted on PubMed.gov with keywords: \"emodin\", \"aloe-emodin\", \"hypericin\", \"parietin\", \"rubiadin\", \"soranjidiol\" with \"cancer\" and \"photodynamic therapy\".
RESULTS: According to literature data, this review concentrated on all existing in vitro and in vivo studies of emodin, aloe-emodin, parietin, rubiadin, soranjidiol used as natural photosensitizers emphasizing their effectiveness and detailed mechanism of action in anticancer therapy. Moreover, comprehensive preclinical and clinical studies on hypericin reveal that the above-described substances may be included in the phototoxic treatment of different cancers.
CONCLUSIONS: Overall, this review presented less-known anthraquinones with their promising molecular mechanisms of action. It is expected that in the future they may be used as natural PSs in cancer treatment as well as hypericin.