未经证实:绒毛膜血管瘤的病因机制尚不清楚。在风险因素中,缺氧,环境和遗传因素被认为可以诱导促血管增殖的血管生成细胞因子的过度表达。我们报告了一例产前诊断为67毫米宽的胎盘绒毛膜血管瘤,发生在胎龄32周,梗塞,然后在胎龄35周时发生第二次梗塞性绒毛膜血管瘤。此外,我们通过文献综述讨论了脉络膜血管瘤的病因和行为假说。
UNASSIGNED:我们在没有时间间隔的情况下对绒毛膜血管瘤病例进行了文献检索。因此,我们对脉络膜血管瘤的危险因素和病因进行了文献总结,通过在1995年至2021年的时间间隔内选择文章。
UNASSIGNED:这是文献中发表的同一妊娠连续两次绒毛膜血管瘤的第一例。我们发现发生绒毛膜血管瘤的女性可能存在遗传易感性,而梗塞可能与肿瘤血管结构异常有关。第二个病变的发作可以反映梗塞后的缺氧刺激,并涉及缺氧诱导因子-1alpha,血管内皮生长因子,转化生长因子-β,和可溶性Fms样酪氨酸激酶-1途径。在易感个体中,脉络膜增生可以共存,并且可能反映出相互的病因。
未经证实:易感胎盘,之前产生了绒毛膜血管瘤,绒毛膜血管瘤的梗塞不应代表终止妊娠的迹象,但更密切监测的标记,以早期发现第二绒毛膜血管瘤的可能发作和更高的脐带血栓形成风险。
UNASSIGNED: Aetiopathogenesis of chorioangioma is already unknown. Among the risk factors, hypoxia, environmental and genetic factors are believed to induce the overexpression of angiogenic cytokines promoting vascular proliferation. We reported a case of prenatally diagnosed 67 mm-wide placental chorioangioma, which occurred at 32 weeks of gestational age, infarcted, and followed by the onset of a second infarcted chorioangioma at 35 weeks of gestational age. Besides, we discussed the hypothesis of chorioangioma aetiopathogenesis and behavior through a literature summary.
UNASSIGNED: We carried out a literature search of chorioangioma cases without a time interval. Therefore, we carried out a literature summary on chorioangioma risk factors and etiology, by selecting articles within a time interval from 1995 to 2021.
UNASSIGNED: This is the first case of two consecutive chorioangiomas in the same pregnancy published in the literature. We found a possible genetic predisposition in women developing chorioangioma while infarction may be related to the abnormal structure of tumor vessels. The onset of a second lesion could reflect hypoxic stimuli following infarction and involves hypoxia-induced factor-1alpha, vascular endothelial growth factor, transforming growth factor-beta, and soluble Fms-like tyrosine kinase-1 pathways. Chorangiosis can be coexistent and may reflect a mutual etiology in susceptible individuals.
UNASSIGNED: In a predisposed placenta, that previously generated a chorioangioma, infarction of the chorioangioma should not represent a sign for pregnancy termination, but a marker for closer monitoring to early detect the possible onset of a second chorioangioma and a higher risk of umbilical cord thrombosis.