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Abstract：
BACKGROUND: Placental chorioangioma is a rare disorder in pregnancy. We retrospectively reviewed the perinatal complications and long-term outcomes in pregnancies with placental chorioangioma and evaluated the factors affecting disease prognosis.
METHODS: We reviewed pregnant women who delivered at our hospital in the past decade and whose diagnosis of placental chorioangioma was confirmed by pathological diagnosis. Information on maternal demographics, prenatal sonographic findings and perinatal outcomes was obtained by reviewing the medical records. In the latter part of the study, follow-up of children was conducted by phone interview.
RESULTS: In the 10 years from August 2008 to December 2018, 175 cases(0.17%) were identified as placental chorioangioma histologically and 44(0.04%) of them were large chorioangiomas. Nearly one-third of cases with large chorioangiomas were associated with severe maternal and fetal complications or required prenatal intervention. Although one-fifth of fetuses/newborns complicated with large chorioangiomas were lost perinatally, the long-term prognosis for surviving fetuses was generally good. Further statistical analysis revealed that tumor size and location affect prognosis.
CONCLUSIONS: Placental chorioangioma may cause an unfavorable perinatal outcome. Regular ultrasound monitoring can provide the tumor characteristics which can be referred to for predicting the tendency of those complications and indicate when intervention may be necessary. It is not clear which factors lead to complications with fetal damage as the main manifestation or polyhydramnios as the main manifestation.
METHODS: We reviewed pregnant women who delivered at our hospital in the past decade and whose diagnosis of placental chorioangioma was confirmed by pathological diagnosis. Information on maternal demographics, prenatal sonographic findings and perinatal outcomes was obtained by reviewing the medical records. In the latter part of the study, follow-up of children was conducted by phone interview.
RESULTS: In the 10 years from August 2008 to December 2018, 175 cases(0.17%) were identified as placental chorioangioma histologically and 44(0.04%) of them were large chorioangiomas. Nearly one-third of cases with large chorioangiomas were associated with severe maternal and fetal complications or required prenatal intervention. Although one-fifth of fetuses/newborns complicated with large chorioangiomas were lost perinatally, the long-term prognosis for surviving fetuses was generally good. Further statistical analysis revealed that tumor size and location affect prognosis.
CONCLUSIONS: Placental chorioangioma may cause an unfavorable perinatal outcome. Regular ultrasound monitoring can provide the tumor characteristics which can be referred to for predicting the tendency of those complications and indicate when intervention may be necessary. It is not clear which factors lead to complications with fetal damage as the main manifestation or polyhydramnios as the main manifestation.
摘要：
背景：胎盘绒毛膜血管瘤是一种罕见的妊娠期疾病。我们回顾性回顾了胎盘绒毛膜血管瘤妊娠的围产期并发症和长期结局，并评估了影响疾病预后的因素。
方法：我们回顾了近十年来我院分娩并经病理诊断证实为胎盘绒毛膜血管瘤的孕妇。关于孕产妇人口统计数据的信息，通过查阅病历获得产前超声检查结果和围产期结局.在研究的后半部分，通过电话采访对儿童进行了随访。
结果：在2008年8月至2018年12月的10年中，有175例（0.17％）在组织学上被确定为胎盘绒毛膜血管瘤，其中44例（0.04％）为大型绒毛膜血管瘤。近三分之一的大型脉络膜血管瘤病例与严重的母体和胎儿并发症或需要产前干预有关。尽管五分之一的胎儿/新生儿并发大脉络膜血管瘤在围生期丢失，存活胎儿的长期预后总体良好.进一步的统计分析表明，肿瘤的大小和位置会影响预后。
结论：胎盘绒毛膜血管瘤可能导致不良的围产期结局。定期超声监测可以提供肿瘤特征，这些特征可以用于预测这些并发症的趋势并指示何时需要干预。尚不清楚哪些因素导致以胎儿损害为主要表现或以羊水过多为主要表现的并发症。
方法：我们回顾了近十年来我院分娩并经病理诊断证实为胎盘绒毛膜血管瘤的孕妇。关于孕产妇人口统计数据的信息，通过查阅病历获得产前超声检查结果和围产期结局.在研究的后半部分，通过电话采访对儿童进行了随访。
结果：在2008年8月至2018年12月的10年中，有175例（0.17％）在组织学上被确定为胎盘绒毛膜血管瘤，其中44例（0.04％）为大型绒毛膜血管瘤。近三分之一的大型脉络膜血管瘤病例与严重的母体和胎儿并发症或需要产前干预有关。尽管五分之一的胎儿/新生儿并发大脉络膜血管瘤在围生期丢失，存活胎儿的长期预后总体良好.进一步的统计分析表明，肿瘤的大小和位置会影响预后。
结论：胎盘绒毛膜血管瘤可能导致不良的围产期结局。定期超声监测可以提供肿瘤特征，这些特征可以用于预测这些并发症的趋势并指示何时需要干预。尚不清楚哪些因素导致以胎儿损害为主要表现或以羊水过多为主要表现的并发症。
