■本研究旨在探索酚类物质的鉴定,酚类物质定量,鲜为人知的泰国水果的抗氧化和潜在的生物功能特性及其治疗2型糖尿病(T2DM)的效力。包括,穿刺术,Dilleniaindica,Diospyrosdecandra,胡枣,弗拉科提亚indica,藤黄,Lepisanthesfruticose,MimusopsElengi,Muntinggiacalabura,网状叶下珠,Streblusasper,柳树,苹果树,通过酚类和类黄酮含量分析了西葫芦和油茶。这些水果受到的科学关注有限,促使对他们的健康益处进行调查,特别是它们与糖尿病管理的相关性。
■该研究利用甲醇粗提物测量酚类和类黄酮水平。此外,UHPLC-DAD用于鉴定和定量酚类。评估甲醇提取物的抗氧化和抗糖尿病能力,包括α-葡萄糖苷酶和α-淀粉酶抑制。
■该研究强调了Cumini是具有强抗氧化活性的酚类(980.42±0.89mgGAE/g和类黄酮(3.55±0.02mgQE/g)化合物的丰富来源(DPPH的IC50;3.00±0.01µg/ml,ABTS的IC50;40±0.01µg/ml,FRAP;898.63±0.02mgTE/ml)。此外,美国Cumini表现出有希望的抗糖尿病作用(S.cuminiIC50;0.13±0.01mg/ml的α-葡萄糖苷酶抑制作用,α-淀粉酶抑制3.91±0.05mg/ml),与阿卡波糖相比(IC50;α-葡萄糖苷酶抑制作用为0.86±0.01mg/ml,α-淀粉酶抑制作用为0.39±0.05mg/ml)。值得注意的是,像儿茶素这样的化合物,没食子酸,山奈酚,和鞣花酸的含量不同。这项研究表明,这些水果,装满了酚类物质,由于其促进健康的特性,具有抗糖尿病饮食甚至药物应用的潜力。
UNASSIGNED: This research aims to explore the phenolics identification, phenolics quantification, antioxidant and potential biofunctional properties of lesser-known Thai fruits and their potency to treat type 2 diabetes mellitus (T2DM). Including, Antidesma puncticulatum, Dillenia indica, Diospyros decandra, Elaeagnus latifolia, Flacourtia indica, Garcinia dulcis, Lepisanthes fruticose, Mimusops elengi, Muntingia calabura, Phyllanthus reticulatus, Streblus asper, Syzygium cumini, Syzygium malaccense, Willughbeia edulis and Schleichera oleosa were analyzed by their
phenolic and flavonoid content. These fruits have received limited scientific attention, prompting an investigation into their health benefits, particularly their relevance to diabetes management.
UNASSIGNED: The study utilized methanolic crude extracts to measure
phenolic and flavonoid levels. Additionally, UHPLC-DAD was utilized to identify and quantify phenolics. The methanolic extracts were assessed for antioxidant and antidiabetic abilities, including α-glucosidase and α-amylase inhibition.
UNASSIGNED: The study highlighted S. cumini as a rich source of
phenolic (980.42 ± 0.89 mg GAE/g and flavonoid (3.55 ± 0.02 mg QE/g) compounds with strong antioxidant activity (IC50 by DPPH; 3.00 ± 0.01 µg/ml, IC50 by ABTS; 40 ± 0.01 µg/ml, FRAP; 898.63 ± 0.02 mg TE/ml). Additionally, S. cumini exhibited promising antidiabetic effects (S. cumini IC50; 0.13 ± 0.01 mg/ml for α-glucosidase inhibition, 3.91 ± 0.05 mg/ml for α-amylase inhibition), compared to Acarbose (IC50; 0.86 ± 0.01 mg/ml for α-glucosidase inhibition, 0.39 ± 0.05 mg/ml for α-amylase inhibition). Remarkably, compounds like catechins, gallic acid, kaempferol, and ellagic acid were identified in various quantities.This study suggests that these fruits, packed with phenolics, hold the potential to be included in an anti-diabetic diet and even pharmaceutical applications due to their health-promoting properties.