■虽然其他地方的事件很少见,在亚洲一些地区,百草枯除草剂中毒是一个严重的医学问题。它会导致各种器官衰竭,包括心脏,肾脏,肝脏,肾上腺,中枢神经系统,肌肉,还有脾脏.由于其固有的毒性和缺乏可用的治疗方法,百草枯的病死率很高。
作者讨论了一例有百草枯摄入史的15岁女性出现呕吐症状,腹痛,和松散的大便。最初,她有胃肠道症状,但是她出现了肾衰竭和呼吸道症状,死于多器官衰竭。
■急性胃肠道坏死和多器官功能衰竭是百草枯摄入的最初影响,在那些在摄入后立即存活下来的人中,肺是中毒的靶器官。摄入大量液体浓缩物会导致暴发性器官衰竭:肺水肿,心脏,肾,和肝功能衰竭,和抽搐。治疗过程可以从单独的支持治疗到免疫调节的各种整合,抗氧化疗法,血液灌流,和血液透析。
■到急诊科就诊的有百草枯中毒史的患者,即使最初症状轻微,也应入院。没有特定的解毒剂可用。早期肾功能衰竭,伴随着进行性肺纤维化,会导致死亡。
UNASSIGNED: While incidents are rare elsewhere, paraquat herbicide poisoning is a serious medical issue in some parts of Asia. It can cause the failure of various organs, including the heart, kidneys, liver, adrenal glands, central nervous system, muscles, and spleen. Due to its inherent toxicity and lack of available therapies, paraquat has a very high case fatality rate.
UNASSIGNED: The authors discuss a case of a 15-year-old female with an alleged history of paraquat ingestion who presented with complaints of vomiting, abdominal pain, and loose stools. Initially, she had gastrointestinal symptoms, but she developed renal failure and respiratory symptoms and died of multiple organ failure.
UNASSIGNED: Acute gastrointestinal tract necrosis and multiorgan failure are the initial effects of paraquat intake, and among those who survive the immediate post-ingestion interval, the lung is the target organ for poisoning. Ingestion of large amounts of liquid concentrates results in fulminant organ failure: pulmonary edema, cardiac, renal, and hepatic failure, and convulsions. The course of treatment can range from supportive care alone to various integration of immune modulation, antioxidant therapy, hemoperfusion, and hemodialysis.
UNASSIGNED: Patients presenting to the emergency department with an alleged history of ingestion of paraquat poisoning should be admitted even if they have mild symptoms initially. There is no specific antidote available. Early renal failure, along with progressive pulmonary fibrosis, can lead to death.