■常规方法,如病史,神经心理学测试,脑脊液检查,在当前的临床环境中,磁共振成像被广泛用于诊断病例,但在对阿尔茨海默病(AD)分期进行分类方面受到限制。AD患者表现出视觉感知缺陷,这可能是根据视觉范式评估疾病严重程度的潜在目标。然而,由于感知对象的形式不一致,当前视觉处理范式的缺陷往往导致结果不一致,缺乏敏感性和特异性。
■我们基于视觉感知的全局优先拓扑方法开发了两种范式,这避免了由于传统范式中感知对象的不一致形式而导致的不一致结果以及缺乏敏感性和特异性,从感知组织(实验1)和视觉工作记忆(VWM)(实验2)中描述一种独特的检测策略。
■除了各组之间反应时间(RTs)的显着差异外,由于相似性检验中全局和局部数字的一致性,当AD受试者识别小数字时发现显着差异。在相似性测试中,与健康老年人(HE)相比,在AD和轻度认知障碍(MCI)组中可以识别出整体和局部特征之间的RTs差异(实验1)。AD患者的记忆能力明显低于MCI组。MCI和HE组均观察到拓扑干扰效果。而MCI患者在非拓扑和拓扑变化方面的差异趋势可能大于HE(实验2)。
■我们的范式提供了一种新的策略,这可以帮助临床严重程度分期,并将视觉感知的拓扑方法与AD的病理生理过程联系起来。
UNASSIGNED: Conventional methods like patient history, neuropsychological testing, cerebrospinal fluid examination, and magnetic resonance imaging are widely used to diagnose cases in the current clinical setting but are limited in classifying Alzheimer\'s disease (AD) stages. Patients with AD exhibit visual perception deficits, which may be a potential target to assess the severity of the disease according to visual paradigms. However, owing to the inconsistent forms of perceived objects, the defects of current visual processing paradigms often lead to inconsistent results and a lack of sensitivity and specificity.
UNASSIGNED: We develop two paradigms based on global-first topological approach of visual perception, which avoids inconsistent results and lack of sensitivity and specificity owing to the inconsistent forms of perceived objects in traditional paradigms, delineate a unique detection strategy from perception organization (Experiment 1) and visual working memory (VWM) (Experiment 2).
UNASSIGNED: Except for the significant differences of the reaction times (RTs) between groups, significant differences were found when AD subjects recognize small figures due to the consistency of global and local figures in similarity test. The difference of RTs between recognizing global and local figures can be recognized in AD and mild cognitive impairment (MCI) group compared to healthy elderly (HE) in similarity test (Experiment 1). The memory capacity of AD patients was significantly lower than MCI group. Topological interference effect was observed in MCI and HE group, whereas MCI patients may have a greater difference trend in non-topological and topological changes than HE (Experiment 2).
UNASSIGNED: Our paradigms provide a new strategy, which can assist clinical severity staging and linking topological approach of visual perception with pathophysiological processes in AD.