背景:儿童创伤与精神分裂症和社会功能障碍的风险增加有关,催产素及其受体基因参与调节社会行为。这项研究调查了催产素和催产素受体基因(OXTR)在介导儿童创伤对精神分裂症社会功能的影响中的潜在作用。
方法:该研究包括382名精神分裂症患者和178名健康对照,他们使用台湾版本的儿童创伤问卷(CTQ-SF)进行评估,社会功能量表(SFS),和血浆催产素水平.提取DNA以对OXTR进行基因分型,并选择十个单核苷酸多态性(SNP;rs2254298,rs237885,rs237887,rs237899,rs53576,rs9840864,rs13316193,rs7632287,rs1042778和rs237895)。
结果:精神分裂症患者表现出更高的CTQ-SF评分(t=12.549,p<0.001),较低的SFS评分(t=-46.951,p<0.001),与健康对照组相比,血浆催产素水平较低(t=-5.448,p<0.001)。该研究还发现两组之间的OXTRSNP存在显着差异,风险等位基因在精神分裂症患者中更为普遍(t=2.734,p=0.006)。结果表明有显著的调节作用,催产素和OXTRSNP部分介导精神分裂症患者童年创伤暴露与社会功能之间的关系(介导指数=0.038,95%CI[0.033-0.044])。
结论:研究结果表明,催产素及其受体基因可能是改善有童年创伤和精神分裂症病史的患者社会功能的有希望的干预目标。然而,需要进一步的研究来充分了解这些影响以及基于催产素的干预措施在这一人群中的潜力.
BACKGROUND: Childhood trauma has been linked to increased risk of schizophrenia and social dysfunction, and oxytocin and its receptor gene have been implicated in regulating social behavior. This study investigated the potential role of oxytocin and oxytocin receptor gene (OXTR) in mediating the effects of childhood trauma on social functioning in schizophrenia.
METHODS: The study consisted of 382 patients with schizophrenia and 178 healthy controls who were assessed using the Taiwanese version of the Childhood Trauma Questionnaire (CTQ-SF), the Social Functioning Scale (SFS), and plasma oxytocin levels. DNA was extracted to genotype the OXTR and ten single-nucleotide polymorphisms (SNPs; rs2254298, rs237885, rs237887, rs237899, rs53576, rs9840864, rs13316193, rs7632287, rs1042778, and rs237895) were selected.
RESULTS: Patients with schizophrenia showed higher CTQ-SF scores (t = 12.549, p < 0.001), lower SFS scores (t = -46.951, p < 0.001), and lower plasma oxytocin levels (t = -5.448, p < 0.001) compared to healthy controls. The study also found significant differences in OXTR SNPs between both groups, with risk alleles being more prevalent in patients with schizophrenia (t = 2.734, p = 0.006). Results indicated a significant moderated mediation effect, with oxytocin and the OXTR SNPs partially mediating the relationship between childhood trauma exposure and social functioning in patients with schizophrenia (index of mediation = 0.038, 95% CI [0.033-0.044]).
CONCLUSIONS: The findings suggest that oxytocin and its receptor gene may be promising targets for interventions aimed at improving social functioning in patients with a history of childhood trauma and schizophrenia. However, further research is needed to fully understand these effects and the potential of oxytocin-based interventions in this population.