Orthotic Devices

矫正装置
  • 文章类型: Journal Article
    本文重点介绍了印度对假肢和矫形服务的需求,以通过早期识别和干预来提高残疾儿童的生活质量。早期干预是对0-6岁发育迟缓和残疾儿童的最早识别和综合服务和支持,以提高他们适应社会的能力。实际的早期干预可延迟或防止未来的并发症,并为儿童的功能性成人生活做好准备。它可能会对不同能力的人及其家庭成员的生活质量产生积极影响,他们可以过积极的个人和社交生活。此外,这些干预措施促进不同能力的人及其父母的福祉和尊严,这可能会导致国民经济的进步。印度的政府和私人机构需要在合格专业人员的领导下进行假肢和矫形康复设施。
    The article focuses on the need for prosthetic and orthotic services in India to improve the quality of life of children with disabilities through early identification and intervention. Early intervention is the earliest identification and comprehensive service and support for children with developmental delays and disabilities ranging from 0 to 6 years to improve their ability to adapt to society. A practical early intervention delays or prevents future complications and prepares the child for functional adult life. It may positively affect the quality of life of the differently abled and their family members, and they can lead an active personal and social life. Also, such interventions promote the well-being and dignity of the differently abled and their parents, which may result in national economic progress. Prosthetic and orthotic rehabilitation facilities under the leadership of qualified professionals are needed in India\'s government and private setups.
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  • 文章类型: Journal Article
    这项研究的目的是检查2例接受ReAktiv后路DynamicElement™(PDE)矫形器和6周康复计划的患者的下肢功能。使用下肢功能评分评估下肢功能,通过2分钟步行测试的步行性能,以及通过单腿平衡的动态移动性和平衡性,定时楼梯上升,和4平方阶跃测试。还实施了为期6周的物理治疗主导的康复计划。数据显示下肢功能改善,行走性能,移动性,佩戴ReAktivPDE™矫形器8周并完成康复计划后进行平衡测量。ReAktivPDE™矫形器与下肢康复计划相结合,显示出作为改善下肢功能和步行表现的治疗选择的潜力,并将高能创伤损伤的患者恢复到健康队列中的功能水平。
    The aim of this study was to examine lower-limb function in 2 patients that received a ReAktiv Posterior Dynamic Element™ (PDE) orthosis and 6-week rehabilitation program after a high-energy trauma injury to the lower limb. Lower-limb function was assessed using the lower extremity functional score, walking performance through the 2-minute walk test, and dynamic mobility and balance through the single-leg balance, timed stair ascent, and the 4-square step test. A 6-week physiotherapy-led rehabilitation program was also implemented. Data showed improvements in lower extremity function, walking performance, mobility, and balance measures after 8 weeks of wearing the ReAktiv PDE™ orthosis and completion of the rehabilitation program. The ReAktiv PDE™ orthosis combined with a lower-limb rehabilitation program shows potential as a treatment option to improve lower-limb function and walking performance and return sufferers of high-energy trauma injury to functional levels seen in healthy cohorts.
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  • 文章类型: Editorial
    暂无摘要。
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  • 文章类型: Journal Article
    背景:2020年,与意大利FightTheStroke基金会家族协会合作成立了一个多专业小组,为2-18岁脑瘫患者的管理和神经运动康复提供循证建议。在意大利的临床实践中实施。
    方法:这些护理途径的建议是根据美国脑瘫和发育医学学会关于护理途径发展的指南和建议的分级评估开发和评估工作组制定的。适应,或从高质量指南(GRADE-ADOLOPMENT)中重新开发建议。
    结果:在综合管理方面提出了四项强有力的积极建议,和二十四解决神经运动治疗。
    结论:整体,在与儿童和青少年融合的学校的网络中,在多维患者概况和跨学科管理方面,个性化方法得到了肯定。定义了所有运动康复方法必须单独定制,考虑到年龄和发展适当的活动作为干预措施和目标,根据描述粗大运动功能和手动能力分类系统预后的参考曲线。干预必须根据对儿童技能的分析来适应任务和/或上下文(对象和环境),以支持动机和避免挫折。
    BACKGROUND: In 2020, a multiprofessional panel was set up in collaboration with the Italian FightTheStroke Foundation family association to produce evidence-based recommendations for the management and neuromotor rehabilitation of persons with cerebral palsy aged 2-18 years to implement in clinical practice in Italy.
    METHODS: The recommendations of these care pathways were developed according to the American Academy for Cerebral Palsy and Developmental Medicine guidelines for Care Pathways Development and the Grading of Recommendations Assessment Development and Evaluation working group for adoption, adaptation, or de novo development of recommendations from high-quality guidelines (GRADE-ADOLOPMENT).
    RESULTS: Four strong positive recommendations were developed regarding comprehensive management, and twenty-four addressed neuromotor treatment.
    CONCLUSIONS: A holistic, individualized approach was affirmed in terms of both multidimensional patient profile and interdisciplinary management in a network with the school where children and adolescents are integrated. It was defined that all motor rehabilitation approaches must be individually tailored considering age and developmentally appropriate activities as interventions and goals, in light of the reference curves addressing prognosis for Gross Motor Function and Manual Ability Classification Systems. Intervention must be structured with adaptations of the task and/or of the context (objects and environment) based on the analysis of the child\'s skills to support motivation and avoid frustration.
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  • 文章类型: Journal Article
    尽管有充分的证据支持踝足矫形器(AFO)可以增强神经肌肉障碍患者的步行能力,康复专业人员普遍认为,使用AFO可能会导致停用和小腿肌肉活动减少。确定AFO干预对神经肌肉障碍患者行走过程中肌电图(EMG)活动的影响。
    搜索了五个数据库,以查找符合预定义纳入标准的研究,并在2024年4月之前的任何时间发表。AFO设计特点,测量的肌肉群,研究设计,实验比较,并从每项研究中提取肌电图参数。使用改良的PEDro量表评估纳入研究的方法学质量。
    20项研究符合纳入标准。利用AFO干预措施,利用EMG结果,结果解释差异很大。在高渗性的情况下,肌电图活动减少被认为是积极的结果,而其他研究则消极地看待它。七项纵向研究发现对EMG活动没有不利的长期影响。
    这篇综述的结果挑战了临床观点,即随着时间的推移,AFO会导致肌肉废用;然而,AFO设计的异质性阻止了与哪些矫形器优化肌肉活动相关的广泛陈述。
    踝足矫形器(AFO)干预对肌电图(EMG)措施的时间和幅度表现出不同的影响,方向上有很大的可变性,量级,和跨研究的解释,需要个性化的方法。纵向研究驳斥了长期使用AFO对EMG活动的不利影响的担忧,挑战减少肌肉激活的概念,并支持延长AFO利用的安全性。建议临床医生在考虑AFO干预时区分周围和中枢神经系统疾病,强调需要使AFO目标与患者的临床表现保持一致,并仔细权衡与AFO利用相关的已知优势。
    UNASSIGNED: Despite ample evidence supporting ankle foot orthoses (AFOs) for enhancing ambulation in those with neuromuscular impairment, a prevalent belief among rehabilitation professionals is that AFO use may lead to disuse and reduced muscle activity of the lower leg. To determine the effects of AFO intervention on electromyography (EMG) activity during walking in individuals with neuromuscular impairment.
    UNASSIGNED: Five databases were searched for studies that met the predefined inclusion criteria and were published any time through April 2024. AFO design characteristics, muscle groups measured, study design, experimental comparisons, and EMG parameters were extracted from each study. Methodological quality of the included studies was assessed using the modified PEDro scale.
    UNASSIGNED: Twenty studies met the inclusion criteria. AFO interventions utilized, EMG outcomes utilized, and result interpretations varied widely. In situations of hypertonicity, reduced EMG activity was deemed a positive outcome, while other studies viewed it negatively. Seven longitudinal studies found no adverse long-term impact on EMG activity.
    UNASSIGNED: The results of this review challenge the clinical belief that AFOs cause muscle disuse over time; however, the heterogeneity of AFO designs prevents broad statements related to which orthoses optimize muscle activity.
    Ankle foot Orthosis (AFO) intervention demonstrates diverse effects on the timing and amplitude of electromyography (EMG) measures, with significant variability in direction, magnitude, and interpretation across studies, necessitating personalized approaches.Longitudinal studies refute concerns about adverse effects on EMG activity with prolonged AFO use, challenging the notion of decreased muscle activation and supporting the safety of extended AFO utilization.Clinicians are advised to differentiate between peripheral and central nervous system disorders when considering AFO intervention, emphasizing the need to align AFO goals with the patient’s clinical presentation and carefully weigh the known advantages associated with AFO utilization.
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  • 文章类型: Journal Article
    背景:医疗级鞋类领域是动态的。最初,一个个体知识的领域,专业知识和技能决定了鞋类及其结果,现在成为一个更加基于证据和数据驱动的领域,有协议和系统来创建合适的鞋类。然而,关于医疗级鞋类的科学证据仍然有限。显然,所有利益相关者,从病人到步行者到康复医生,将受益于这一领域更大的证据基础。广泛支持的研究议程是推进和促进新知识的重要第一步。
    方法:我们组建了一个多学科团队,并遵循了荷兰医学学会的方法,制定了医疗级鞋类研究议程。这包括七个步骤:(1)与用户和专业人员盘点相关问题;(2)分析回答;(3)分析现有知识和证据;(4)制定研究问题;(5)用户和专业人员优先考虑研究问题;(6)最终确定研究议程;(7)实施研究议程。
    结果:在第一阶段,109名参与者完成了一项调查,包括50%的学童师,6%的康复医生和3%的用户。参与者提供了228个潜在的研究问题。在第2-4阶段,这些被浓缩为65个研究问题。在第5阶段,152名参与者优先考虑了这65个研究问题,包括50%的学童师,13%的康复医生和9%的用户。在第六阶段,最终研究议程已经制定,有26个研究问题,根据国际功能障碍和健康分类“过程描述辅助设备”进行分类。在第7阶段,与50多个利益攸关方(包括用户和专业人员)举行了一次执行会议,根据研究议程中的一个或多个研究问题,提出了七个研究项目申请。
    结论:本研究议程构建并指导荷兰和其他地方医疗级鞋类领域的知识发展。我们希望这将有助于刺激该领域解决优先考虑的研究问题,并以此来推进该领域的科学知识。
    BACKGROUND: The field of medical grade footwear is dynamic. Originally, a field where individual knowledge, expertise and skills determined the footwear and its outcomes, now becoming a more evidence-based and data-driven field with protocols and systems in place to create appropriate footwear. However, scientific evidence concerning medical grade footwear is still limited. Evidently, all stakeholders, from patients to pedorthists to rehabilitation physicians, will profit from a larger evidence-base in this field. A widely supported research agenda is an essential first step to advance and facilitate new knowledge.
    METHODS: We formed a multidisciplinary team and followed the methodology from Dutch medical societies for the development of a research agenda on medical grade footwear. This consisted of seven steps: (1) inventory of relevant questions with users and professionals; (2) analyses of responses; (3) analyses of existing knowledge and evidence; (4) formulating research questions; (5) prioritising research questions by users and professionals; (6) finalising the research agenda and (7) implementing the research agenda.
    RESULTS: In phase 1, 109 participants completed a survey, including 50% pedorthists, 6% rehabilitation physicians and 3% users. Participants provided 228 potential research questions. In phases 2-4, these were condensed to 65 research questions. In phase 5, 152 participants prioritised these 65 research questions, including 50% pedorthists, 13% rehabilitation physicians and 9% users. In phase 6, the final research agenda was created, with 26 research questions, categorised based on the International Classification of Functioning Disability and Health \'process description assistive devices\'. In phase 7, an implementation meeting was held with over 50 stakeholders (including users and professionals), resulting in seven applications for research projects based on one or more research questions from the research agenda.
    CONCLUSIONS: This research agenda structures and guides knowledge development within the field of medical grade footwear in the Netherlands and elsewhere. We expect that this will help to stimulate the field to tackle the research questions prioritised and with that to advance scientific knowledge in this field.
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  • 文章类型: Journal Article
    目的:回顾性评估两种轮椅座椅系统的比较效果,定制外形轮椅座椅(CCS)和模块化轮椅座椅(MWS),关于患有神经肌肉和神经系统疾病的儿童的脊柱侧凸进展,并确定脊柱侧凸进展的任何预测因素。
    方法:纵向,回顾性队列研究设置:国家卫生服务区域姿势和行动服务参与者:患有神经肌肉和神经系统疾病的非门诊儿科轮椅使用者(N=75;36男性,39名女性;座位干预时的平均年龄,10.50±3.97年)由南威尔士态势和机动性服务于2012年至2022年发布的CCS和MWS。
    方法:两种专门的轮椅座椅系统,CCS和MWS。
    方法:使用广义最小二乘(GLS)模型来估计座椅类型随时间对Cobb角的影响。
    结果:在75名参与者中,51%有脑瘫。50个发行了CCS,25个发行了MWS。MWS组的基线Cobb角为32.9±18.9°,CCS组为48.0±31.0°。GLS模型证明了自坐位干预以来的时间(χ2=122,p<0.0001),座椅类型(χ2=52.5,p<0.0001),和基线脊柱侧凸严重程度(χ2=41.6,p<0.0001)可预测脊柱侧凸进展。条件不是一个强有力的预测因子(χ2=9.96,p=.0069),性别(χ2=5.67,p=.13)和干预年龄(χ2=4.47,p=.35)均无预测作用。随着时间的推移,医疗状况与座椅类型的估计对比表明,随着时间的推移,MWS和CCS之间的差异较小。与MWS相比,预测的脊柱侧凸速度随着时间的推移随着CCS的使用而减弱。虽然,脊柱侧凸恶化,无论干预。
    结论:我们的研究结果表明,与MWS相比,患有神经和神经肌肉疾病的儿童轮椅使用者,CCS处方显示随着时间的推移脊柱侧凸进展有更大的缓解。
    OBJECTIVE: To retrospectively evaluate the comparative effect of 2 wheelchair seating systems, Custom-Contoured Wheelchair Seating (CCS) and Modular Wheelchair Seating (MWS), on scoliosis progression in children with neuromuscular and neurologic disorders and to determine any predictors for scoliosis progression.
    METHODS: Longitudinal, retrospective cohort study.
    METHODS: A national health service regional posture and mobility service.
    METHODS: Nonambulant pediatric wheelchair users with neuromuscular and neurologic disorders (N=75; 36 men, 39 women; mean age at seating intervention, 10.50±3.97y) issued CCS and MWS by the South Wales Posture and Mobility Service from 2012-2022.
    METHODS: Two specialized wheelchair seating systems, CCS and MWS.
    METHODS: A generalized least squares model was used to estimate the effect of seat type on Cobb angle over time.
    RESULTS: Of the 75 participants enrolled, 51% had cerebral palsy. Fifty were issued CCS and 25 were issued MWS. Baseline Cobb angle was 32.9±18.9° for the MWS group and 48.0±31.0° for the CCS group. The generalized least squares model demonstrated that time since seating intervention (χ2=122, P<.0001), seating type (χ2=52.5, P<.0001), and baseline scoliosis severity (χ2=41.6, P<.0001) were predictive of scoliosis progression. Condition was not a strong predictor (χ2=9.96, P =.0069), and sex (χ2=5.67, P=.13) and age at intervention (χ2=4.47, P=.35) were not predictive. Estimated contrasts of medical condition with seat type over time demonstrated smaller differences between MWS and CCS over time. Predicted scoliosis velocity was found to attenuate with use of CCS over time compared with MWS, although scoliosis deteriorated regardless of intervention.
    CONCLUSIONS: Our findings showed pediatric wheelchair users with neurologic and neuromuscular disorders prescribed CCS showed greater mitigation of scoliosis progression over time compared with those issued MWS.
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  • DOI:
    文章类型: Journal Article
    步行是一种至关重要的活动,在患有神经病的个体中经常受到损害。Charcot-Marie-Tooth(CMT)疾病和脑瘫(CP)是两种常见的影响步态的神经发育障碍,容易跌倒的危险。由于指导科学证据有限,迫切需要更好地了解手术矫正如何影响活动性,平衡信心,和步态相比踝足矫形器(AFO)支架。系统的方法将使严格的合作研究能够推进临床护理。
    此愿景的关键要素包括1)在选定的患者队列中进行前瞻性研究,以系统地比较保守性与手术管理,2)客观的基于实验室的患者流动性评估,balance,和步态使用可靠的方法,和3)使用与健康和流动性相关的以患者为中心的结果测量。
    文献中已经描述了有效且可靠的身体移动性和平衡置信度的标准化测试。它们包括1)四方阶跃测试,一种广泛使用的平衡和敏捷性测试,可以预测跌倒风险,2)自选步行速度,一种能够检测矫形器使用时功能变化的总体移动性度量,和3)活动特定平衡置信度量表,一种评估个人在活动期间平衡信心水平的调查工具。此外,运动捕获和地面反作用力数据可用于评估全身运动和载荷,在步态摆动阶段,包括脚趾间隙在内的有区别的生物力学措施,50%摆动时的足底弯曲,踝关节足底屈肌峰值力矩,和峰值脚踝推脱力。
    在这些具有挑战性的患者群体中,支持循证实践和告知临床决策所需的工具都是可用的。现在必须进行研究,以更好地了解在患有神经病的个体步态期间的移动性和平衡的背景下使用AFO的潜在益处和局限性。特别是相对于那些通过手术矫正提供。
    遵循这一研究路径将提供流动性的比较基线数据,平衡信心,和步态,可用于告知基于客观标准的AFO处方方法和手术干预的影响。
    UNASSIGNED: Walking is a vital activity often compromised in individuals with neuropathic conditions. Charcot-Marie-Tooth (CMT) disease and Cerebral Palsy (CP) are two common neurodevelopmental disabilities affecting gait, predisposing to the risk of falls. With guiding scientific evidence limited, there is a critical need to better understand how surgical correction affects mobility, balance confidence, and gait compared to ankle foot orthosis (AFO) bracing. A systematic approach will enable rigorous collaborative research to advance clinical care.
    UNASSIGNED: Key elements of this vision include 1) prospective studies in select patient cohorts to systematically compare conservative vs. surgical management, 2) objective laboratory-based evaluation of patient mobility, balance, and gait using reliable methods, and 3) use of patient-centric outcome measures related to health and mobility.
    UNASSIGNED: Valid and reliable standardized tests of physical mobility and balance confidence have been described in the literature. They include 1) the four-square step test, a widely used test of balance and agility that predicts fall risk, 2) the self-selected walking velocity, a measure of general mobility able to detect function change with orthosis use, and 3) the activity specific balance confidence scale, a survey instrument that assesses an individual\'s level of balance confidence during activity. Additionally, motion capture and ground reaction force data can be used to evaluate whole-body motion and loading, with discriminative biomechanical measures including toe clearance during the swing phase of gait, plantarflexion at 50% of swing, peak ankle plantarflexor moment, and peak ankle push-off power.
    UNASSIGNED: The tools needed to support evidence-based practice and inform clinical decision making in these challenging patient populations are all available. Research must now be conducted to better understand the potential benefits and limitations of AFO use in the context of mobility and balance during gait for individuals with neuropathic conditions, particularly relative to those offered by surgical correction.
    UNASSIGNED: Following this path of research will provide comparative baseline data on mobility, balance confidence, and gait that can be used to inform an objective criterion-based approach to AFO prescription and the impact of surgical intervention.
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  • 文章类型: Journal Article
    背景:矫形器在不同治疗效果的外翻(HV)的保守治疗中起着重要作用。在这项研究中,使用三维(3D)打印技术开发了一种新的HV矫形器。此外,使用运动分析评估其运动学效果。
    方法:17名HV角度>20°的参与者被纳入研究。静态测量矫形器前后的第一and趾外展角。随后,动态第一跖趾外展,使用Vicon运动分析系统和测力板记录和计算行走过程中有无矫形器的背屈角度和地面反作用力。运动分析后确定患者的舒适度等级。
    结果:在静态和动态条件下,第一and趾外展中矫形器的角度校正分别为14.6°和6.3°,分别。在早期站立阶段,矫形器观察到了减少的拇指背屈。然而,没有观察到地面反作用力的显着变化。
    结论:我们的研究结果证实了3D打印HV矫形器在静态和动态矫正畸形方面的潜力,同时确保患者的舒适度,同时对拇指运动学的影响最小,表明我们的设计长期使用的潜力。
    BACKGROUND: Orthoses play an important role in the conservative treatment of hallux valgus (HV) with different therapeutic effects. In this study, a new HV orthosis was developed using three-dimensional (3D) printing technology. In addition, its kinematic effect was evaluated using motion analysis.
    METHODS: Seventeen participants with an HV angle of >20° were included in the study. The first metatarsophalangeal abduction angle before and after the orthosis was measured statically. Subsequently, dynamic first metatarsophalangeal abduction, dorsiflexion angle and ground reaction force with and without the orthosis were recorded and calculated during walking using a Vicon motion analysis system and force plates. The patients\' comfort scales were determined after the motion analysis.
    RESULTS: The angular corrections of the orthosis in the first metatarsophalangeal abduction were 14.6° and 6.3° under static and dynamic conditions, respectively. Reduced hallux dorsiflexion was observed with the orthosis in the early stance phase. However, no significant changes in ground reaction forces were observed.
    CONCLUSIONS: The results of our study confirm the potential of the 3D-printed HV orthosis in the static and dynamic correction of deformities while ensuring patient comfort with minimal impact on hallux kinematics, suggesting the potential of our design for long-term use.
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  • 文章类型: Systematic Review
    背景:本系统评价的目的是确定足跟提升对下肢肌肉骨骼疾病的任何比较者的益处和危害。
    方法:OvidMEDLINE,OvidAMED,OvidEMCARE,从开始到2024年5月底,搜索了CINAHLPlus和SPORTDiscus。随机化,比较足跟提升与任何其他干预或无治疗的准随机或非随机试验均可纳入.提取了疼痛结果的数据,残疾/功能,参与,参与者总体状况评级,生活质量,综合措施和不良事件。两位作者在主要时间点12周(或次接近)使用GRADE方法独立评估偏倚和证据确定性的风险。
    结果:8项试验(n=903),调查中段跟腱病,包括跟骨关节炎和足底足跟痛。高跟鞋被比作运动,超声,冷冻疗法矫形器,伸展,鞋类,活动修改,毡垫和止痛药。没有结果的偏倚风险较低,几乎没有影响(47个中的2个)是临床重要的。低确定性证据(1次试验,n=199)表示疼痛缓解改善(55.7分[95%CI:50.3-61.1],在100毫米视觉模拟量表上)与定制矫形器相比,与跟骨关节炎12周时的脚跟抬起相比。非常低的确定性证据(1次试验,n=62)表示与消炎痛相比,足跟抬起的疼痛和功能得到改善(35.5分[95%CI:21.1-49.9],足功能指数)在12个月时治疗足底足跟痛。
    结论:很少有试验评估足跟提升对下肢肌肉骨骼疾病的益处和危害。47个结果中只有两个结果在组间差异中显示出临床意义。然而,由于非常低到低确定性的证据,我们无法对结果充满信心,真正的效果可能大不相同。
    背景:PROSPERO注册号CRD42022309644。
    BACKGROUND: The objective of this systematic review is to determine the benefits and harms of heel lifts to any comparator for lower limb musculoskeletal conditions.
    METHODS: Ovid MEDLINE, Ovid AMED, Ovid EMCARE, CINAHL Plus and SPORTDiscus were searched from inception to the end of May 2024. Randomised, quasi-randomised or non-randomised trials comparing heel lifts to any other intervention or no-treatment were eligible for inclusion. Data was extracted for the outcomes of pain, disability/function, participation, participant rating of overall condition, quality of life, composite measures and adverse events. Two authors independently assessed risk of bias and certainty of evidence using the GRADE approach at the primary time point 12 weeks (or next closest).
    RESULTS: Eight trials (n = 903), investigating mid-portion Achilles tendinopathy, calcaneal apophysitis and plantar heel pain were included. Heel lifts were compared to exercise, ultrasound, cryotherapy orthotics, stretching, footwear, activity modification, felt pads and analgesic medication. No outcome was at low risk of bias and few effects (2 out of 47) were clinically important. Low-certainty evidence (1 trial, n = 199) indicates improved pain relief (55.7 points [95% CI: 50.3-61.1], on a 100 mm visual analogue scale) with custom orthotics compared to heel lifts at 12 weeks for calcaneal apophysitis. Very low-certainty evidence (1 trial, n = 62) indicates improved pain and function with heel lifts over indomethacin (35.5 points [95% CI: 21.1-49.9], Foot Function Index) at 12 months for plantar heel pain.
    CONCLUSIONS: Few trials have assessed the benefits and harms of heel lifts for lower limb musculoskeletal conditions. Only two outcomes out of 47 showed clinically meaningful between group differences. However, due to very low to low certainty evidence we are unable to be confident in the results and the true effect may be substantially different.
    BACKGROUND: PROSPERO registration number CRD42022309644.
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