背景:妊娠期低密度脂蛋白胆固醇(LDL-C)水平升高与不良妊娠和后代结局相关。虽然先前的研究表明,在普通人群和农业工人中,有机磷农药(OPP)暴露与较高的LDL-C之间存在潜在的联系,孕妇的关系以及体重指数对这种关系的影响尚不清楚。我们检查了孕妇尿液中OPP代谢物(二烷基磷酸酯)的浓度与血脂水平之间的关系。
方法:我们使用了日本环境与儿童研究的数据,其中包括5,169名孕妇的尿磷酸二烷基酯数据。我们检查了六种磷酸二烷基酯的尿液浓度之间的关联(DEP,DETP,DEDTP,DMP,DMTP,DMDTP)和血脂水平(LDL-C,总胆固醇,高密度脂蛋白胆固醇,和甘油三酯)在前三个月期间使用贝叶斯范式下的多元线性回归。我们检查了高LDL-C,定义为LDL-C≥90百分位数,和尿中磷酸二烷基酯浓度,在贝叶斯范式下使用多元逻辑回归。这些分析在体重不足的情况下重复进行,正常体重,超重的参与者。
结果:DEP,DMP,在>50%的参与者中检测到DMTP。多元线性回归分析未显示LDL-C与这些磷酸二烷基酯之间的关联。分层分析显示,超重女性的DEP和LDL-C之间呈正相关(β系数=2.13,95%可信区间=0.86-3.38,方向概率(PD)=100%);但是,相关性不显著(实际等效地区的百分比(ROPE中的%)=84.0).较高的DEP与高LDL-C显著相关(比值比=1.32,95%可信区间=1.13-1.55,PD=100%,以绳索计的%=0.2)。
结论:在妊娠早期超重的孕妇中,较高的尿DEP浓度与高LDL-C相关。OPP对血脂谱的影响值得进一步研究。
BACKGROUND: High low-density lipoprotein cholesterol levels (LDL-C) during pregnancy have been associated with adverse pregnancy and offspring outcomes. While previous studies have suggested a potential link between organophosphate pesticide (OPP) exposure and higher LDL-C in the general population and agricultural workers, the relationship in pregnant women and the effect of body mass index on this relationship remain unclear. We examined the association between the urinary concentrations of OPP metabolites (dialkylphosphates) and blood lipid levels in pregnant women.
METHODS: We used data from the Japan Environment and Children\'s Study, which included 5,169 pregnant women with urinary dialkylphosphate data. We examined the association between urinary concentrations of six dialkylphosphates (DEP, DETP, DEDTP, DMP, DMTP, DMDTP) and blood lipid levels (LDL-C, total cholesterol, high-density lipoprotein cholesterol, and triglycerides) during the first trimester using multiple linear regression under a Bayesian paradigm. We examined the association between high LDL-C, defined as ≥90th percentile of LDL-C, and urinary dialkylphosphate concentrations, using multiple logistic regression under a Bayesian paradigm. These analyses were repeated in underweight, normal-weight, and overweight participants.
RESULTS: DEP, DMP, and DMTP were detected in >50 % of the participants. Multiple linear regression analyses did not show associations between LDL-C and these dialkylphosphates. Stratified analyses showed a positive association between DEP and LDL-C in overweight women (beta coefficient = 2.13, 95 % credible interval = 0.86-3.38, probability of direction (PD) = 100 %); however, the association was not significant (percentage in region of practical equivalence (% in ROPE) = 84.0). Higher DEP was significantly associated with high LDL-C (odds ratio = 1.32, 95 % credible interval = 1.13-1.55, PD = 100 %, % in ROPE = 0.2).
CONCLUSIONS: Among overweight pregnant women in the first trimester, higher urinary DEP concentrations were associated with high LDL-C. The effects of OPP on blood lipid profiles merit further investigation.