背景:印度的传统医疗体系,阿育吠陀,提到CordiaDichotoma是各种疾病的潜在治疗方法。在目前的研究中,对CordiaDichotoma的提取物进行了检查,以评估其抗抑郁潜力。
方法:这里,使用CordiaDichotoma的绿色叶子来制备氯仿,乙醇,和水提取物(称为CdCe,CdEe,和CdAe分别)。研究的重点是在实验动物中使用行为模型研究这些提取物的抗抑郁作用。此外,运动活动作为评估过程的一部分进行评估.
结果:当CdEeCordiaDichotomarFST和mTST在200mg/kg和400mg/kg体重时,不动时间减少。在重复的rFST中,CdAe显示出固定时间的减少)在400mg/kg,而在MTST,在200和400mg/kg时观察到显着的效果。关于氯仿提取物,在200mg/kg的低剂量下,其仅在改良的尾部悬浮试验(mTST)中表现出不动时间的显著减少。然而,在200和400mg/kg的剂量下,CCl4和水提取物未观察到运动功能障碍的明显变化。值得注意的是,在相同剂量水平下,氯仿提取物(CdCe)确实导致运动活性的显著降低。一起来看,这些发现表明,从CordiaDichotoma叶获得的提取物可能具有抗抑郁特性。
BACKGROUND: The traditional medicinal system of India, Ayurveda, has mentioned Cordia Dichotoma as a potential treatment for various ailments. In the current research, the extracts of Cordia Dichotoma was examined to evaluate their antidepressant potential.
METHODS: Here, green leaves of Cordia Dichotoma were used to prepare chloroform, ethanol, and aqueous extracts (referred to as CdCe, CdEe, and CdAe respectively). The research focused on investigating the antidepressant effects of these extracts using behavioral models in experimental animals. Additionally, locomotor activity was assessed as part of the evaluation process.
RESULTS: Immobility time was reduced with CdEe Cordia Dichotoma rFST & mTST when at 200 mg/kg and 400 mg/kg body weight. The CdAe showed reduction in immobility time in the repeated rFST) at 400 mg/kg, while in the mTST, significant effects were observed at 200 and 400 mg/kg. Regarding the chloroform extract, it only exhibited a significant reduction in immobility time in the modified Tail Suspension Test (mTST) at a low dose of 200 mg/kg. However, no noticeable change in motor dysfunction was observed with CCl4 and aqueous extracts at doses of 200 and 400 mg/kg. It is worth noting that the chloroform extract (CdCe) did lead to a significant decrease in locomotor activity at the same dosage level. Taken together, these findings suggest that extracts obtained from Cordia Dichotoma leaves may possess antidepressant properties.