目的:持续的听觉言语幻觉(pAVHs)和嗅觉识别障碍在精神分裂症(SCZ)中很常见,但pAVHs和嗅觉识别障碍的神经影像学机制尚不清楚.这项研究旨在调查SCZ患者的pAVHs和嗅觉识别障碍是否与皮质厚度的变化有关。
方法:在本研究中,研究了78例SCZpAVHs患者(pAVH组)的皮质厚度,58例SCZ患者无AVH(非AVH组),83例健康对照(HC组)采用3T磁共振成像。通过听觉幻觉评定量表评估pAVHs的严重程度。使用日本气味棒鉴定测试(OSIT-J)评估嗅觉鉴定缺陷。此外,确定了pAVHs的严重程度与嗅觉识别障碍和皮质厚度异常之间的关系。
结果:与非AVH和HC组相比,pAVH组的右内侧眶沟(嗅沟)和右眶沟(H形沟)的皮质厚度明显减少(P<.003,Bonferroni校正)。此外,发现pAVHs的严重程度与嗅沟和H形沟中皮质厚度的减少呈负相关。此外,嗅沟皮质厚度的减少与OSIT-J评分呈正相关(P<.05,错误发现率校正).
结论:嗅沟皮质厚度异常可能是SCZ患者pAVH和嗅觉识别缺陷的常见神经影像学机制。
OBJECTIVE: Persistent auditory verbal hallucinations (pAVHs) and olfactory identification impairment are common in schizophrenia (SCZ), but the neuroimaging mechanisms underlying both pAVHs and olfactory identification impairment are unclear. This study aimed to investigate whether pAVHs and olfactory identification impairment in SCZ patients are associated with changes in cortical thickness.
METHODS: In this study, cortical thickness was investigated in 78 SCZ patients with pAVHs (pAVH group), 58 SCZ patients without AVHs (non-AVH group), and 83 healthy controls (HC group) using 3T magnetic resonance imaging. The severity of pAVHs was assessed by the Auditory Hallucination Rating Scale. Olfactory identification deficits were assessed using the Odor Stick Identification Test for Japanese (OSIT-J). In addition, the relationship between the severity of pAVHs and olfactory identification disorder and cortical thickness abnormalities was determined.
RESULTS: Significant reductions in cortical thickness were observed in the right medial orbital sulcus (olfactory sulcus) and right orbital sulcus (H-shaped sulcus) in the pAVH group compared to both the non-AVH and HC groups (P < .003, Bonferroni correction). Furthermore, the severity of pAVHs was found to be negatively correlated with the reduction in cortical thickness in the olfactory sulcus and H-shaped sulcus. Additionally, a decrease in cortical thickness in the olfactory sulcus showed a positive correlation with the OSIT-J scores (P < .05, false discovery rate correction).
CONCLUSIONS: Cortical thickness abnormalities in the olfactory sulcus may be a common neuroimaging mechanism for pAVHs and olfactory identification deficits in SCZ patients.