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Abstract：
The olfactory system plays crucial roles in perceiving and interacting with their surroundings. Previous studies have deciphered basic odor perceptions, but how information processing in the olfactory system is associated with learning and memory is poorly understood. In this review, we summarize recent studies on the anatomy and functional dynamics of the mouse olfactory learning pathway, focusing on how neuronal circuits in the olfactory bulb (OB) and olfactory cortical areas integrate odor information in learning. We also highlight in vivo evidence for the role of the lateral entorhinal cortex (LEC) in olfactory learning. Altogether, these studies demonstrate that brain regions throughout the olfactory system are critically involved in forming and representing learned knowledge. The role of olfactory areas in learning and memory, and their susceptibility to dysfunction in neurodegenerative diseases, necessitate further research.
摘要：
嗅觉系统在感知周围环境和与周围环境互动中起着至关重要的作用。以前的研究已经破译了基本的气味感知，但是嗅觉系统中的信息处理如何与学习和记忆相关联，人们知之甚少。在这次审查中,我们总结了最近关于小鼠嗅觉学习途径的解剖和功能动力学的研究，重点研究嗅球（OB）和嗅觉皮质区域的神经元回路如何在学习中整合气味信息。我们还强调了体内外嗅皮层（LEC）在嗅觉学习中的作用。总之,这些研究表明，整个嗅觉系统的大脑区域在形成和代表所学知识方面至关重要。嗅觉区在学习和记忆中的作用，以及它们对神经退行性疾病功能障碍的易感性，需要进一步的研究。
