目的:评估六种超声(US)确定的剪切波(SW)粘弹性成像参数的可重复性,用于评估志愿者和活检证实的代谢功能障碍相关脂肪性肝炎(MASLD)或代谢功能障碍相关脂肪性肝炎(MASH)患者的肝脏机械特性。
方法:这种前瞻性,横截面,机构审查委员会批准的研究包括10名志愿者和20名接受两次肝脏超声弹性成像的MASLD或MASH患者,至少相隔两周。SW速度(SWS),杨氏模量(E),剪切模量(G),SW衰减(SWA),SW色散(SWD),和粘度是根据美国研究型扫描仪上记录的射频数据计算的。使用线性混合模型将值班超声医师视为混杂因素。通过组内相关系数(ICC)评估测量的可重复性,变异系数(CV),再现性系数(RDC),和Bland-Altman分析.
结果:进行检查的超声医师对粘弹性参数没有影响(P>.05)。SWS的ICC,E,G,SWA,SWD,和粘度是,分别,0.89(95%置信区间[CI]:0.79-0.95),0.81(95%CI:0.79-0.95),0.90(95%CI:0.80-0.95),0.96(95%CI:0.93-0.98),0.78(95%CI:0.60-0.89),和0.90(95%CI:0.80-0.95);CV分别为11.9、23.3、24.2、10.1、29.0和32.2%;RDC分别为33.0、64.5、66.9、27.7、80.3和89.2%,Bland-Altman的平均偏差和95%的一致性界限为-0.05(-0.45,0.35)m/s,-0.61(-5.33,4.10)kPa,-0.25(-2.06,1.56)kPa,-0.01(-0.27,0.26)Np/m/Hz,-0.09(-7.09,6.91)m/s/kHz,和-0.33(-2.60,1.94)Pa/s,在两次访问之间。
结论:在同一超声机器上间隔2周的两次访问之间,可以以高可重复性和一致性测量US确定的粘弹性成像参数。
OBJECTIVE: To assess the reproducibility of six ultrasound (US)-determined shear wave (SW) viscoelastography parameters for assessment of mechanical properties of the liver in volunteers and patients with biopsy-proven metabolic dysfunction-associated steatotic liver disease (MASLD) or metabolic dysfunction-associated steatohepatitis (MASH).
METHODS: This prospective, cross-sectional, institutional review board-approved study included 10 volunteers and 20 patients with MASLD or MASH who underwent liver US elastography twice, at least 2 weeks apart. SW speed (SWS), Young\'s modulus (E), shear modulus (G), SW attenuation (SWA), SW dispersion (SWD), and viscosity were computed from radiofrequency data recorded on a research US scanner. Linear mixed models were used to consider the sonographer on duty as a confounder. The reproducibility of measurements was assessed by intraclass correlation coefficient (ICC), coefficient of variation (CV), reproducibility coefficient (RDC), and Bland-Altman analyses.
RESULTS: The sonographer performing the exam had no impact on viscoelastic parameters (P > .05). ICCs of SWS, E, G, SWA, SWD, and viscosity were, respectively, 0.89 (95% confidence intervals [CI]: 0.79-0.95), 0.81 (95% CI: 0.79-0.95), 0.90 (95% CI: 0.80-0.95), 0.96 (95% CI: 0.93-0.98), 0.78 (95% CI: 0.60-0.89), and 0.90 (95% CI: 0.80-0.95); CVs were 11.9, 23.3, 24.2, 10.1, 29.0, and 32.2%; RDCs were 33.0, 64.5, 66.9, 27.7, 80.3, and 89.2%, and Bland-Altman mean biases and 95% limits of agreement were -0.05 (-0.45, 0.35) m/s, -0.61 (-5.33, 4.10) kPa, -0.25 (-2.06, 1.56) kPa, -0.01 (-0.27, 0.26) Np/m/Hz, -0.09 (-7.09, 6.91) m/s/kHz, and -0.33 (-2.60, 1.94) Pa/s, between the two visits.
CONCLUSIONS: US-determined viscoelastography parameters can be measured with high reproducibility and consistency between two visits 2 weeks apart on the same ultrasound machine.