PDF(Pubmed)
Abstract：
UNASSIGNED: The incidence of steatotic liver disease has increased in recent years. Thus, steatotic liver disease is a major public health issue in Japan. This study investigated the association between weight reduction and the remission of metabolic dysfunction-associated steatotic liver disease (MASLD)/Metabolic and alcohol related/associated liver disease (MetALD) in Japanese individuals undergoing health checkups.
UNASSIGNED: This retrospective observational study included 8,707 Japanese patients with MASLD/MetALD who underwent health checkups from May 2015 to March 2023. The participants were monitored for its remission at their subsequent visit. MASLD was diagnosed on abdominal ultrasonography and based on the presence of at least one of five metabolic abnormalities. The impact of body mass index (BMI) reduction on MASLD/MetALD remission was assessed via logistic regression analysis and using receiver operating characteristic curves.
UNASSIGNED: Logistic regression analysis revealed that weight loss was significantly associated with MASLD/MetALD remission. Other factors including exercise habits and reduced alcohol consumption were significant predictors of MASLD/MetALD remission in the overall cohort and in male patients. The optimal BMI reduction cutoff values for MASLD/MetALD remission were 0.9 kg/m2 and 4.0% decrease in the overall cohort, 0.85 kg/m2 and 3.9% decrease in males, and 1.2 kg/m2 and 4.5% decrease in females. In participants with a BMI of 23 kg/m2, the cutoff values were 0.75 kg/m2 and 2.7% BMI reduction.
UNASSIGNED: Weight reduction plays an important role in both MASLD and MetALD remission among Japanese individuals. That is, targeting specific BMI reduction is effective. This underscores the importance of targeted weight management strategies in preventing and managing MASLD/MetALD in the Japanese population.
UNASSIGNED: This retrospective observational study included 8,707 Japanese patients with MASLD/MetALD who underwent health checkups from May 2015 to March 2023. The participants were monitored for its remission at their subsequent visit. MASLD was diagnosed on abdominal ultrasonography and based on the presence of at least one of five metabolic abnormalities. The impact of body mass index (BMI) reduction on MASLD/MetALD remission was assessed via logistic regression analysis and using receiver operating characteristic curves.
UNASSIGNED: Logistic regression analysis revealed that weight loss was significantly associated with MASLD/MetALD remission. Other factors including exercise habits and reduced alcohol consumption were significant predictors of MASLD/MetALD remission in the overall cohort and in male patients. The optimal BMI reduction cutoff values for MASLD/MetALD remission were 0.9 kg/m2 and 4.0% decrease in the overall cohort, 0.85 kg/m2 and 3.9% decrease in males, and 1.2 kg/m2 and 4.5% decrease in females. In participants with a BMI of 23 kg/m2, the cutoff values were 0.75 kg/m2 and 2.7% BMI reduction.
UNASSIGNED: Weight reduction plays an important role in both MASLD and MetALD remission among Japanese individuals. That is, targeting specific BMI reduction is effective. This underscores the importance of targeted weight management strategies in preventing and managing MASLD/MetALD in the Japanese population.
摘要：
■近年来，脂肪变性肝病的发病率有所增加。因此，在日本，脂肪肝是一个重大的公共卫生问题。这项研究调查了在接受健康检查的日本个体中，体重减轻与代谢功能障碍相关的脂肪变性肝病（MASLD）/代谢和酒精相关/相关肝病（MetALD）的缓解之间的关联。
这项回顾性观察研究包括8,707名日本MASLD/MetALD患者，他们从2015年5月至2023年3月接受了健康检查。在随后的访问中监测参与者的缓解情况。通过腹部超声检查并基于五种代谢异常中的至少一种来诊断MASLD。通过逻辑回归分析并使用受试者工作特征曲线评估体重指数（BMI）降低对MASLD/MetALD缓解的影响。
■Logistic回归分析显示，体重减轻与MASLD/MetALD缓解显著相关。在整个队列和男性患者中，包括运动习惯和饮酒减少在内的其他因素是MASLD/MetALD缓解的重要预测因素。MASLD/MetALD缓解的最佳BMI降低临界值为0.9kg/m2，在整个队列中降低4.0%，0.85公斤/平方米，男性减少3.9%，女性减少1.2公斤/平方米，减少4.5%。在BMI为23kg/m2的参与者中，临界值为0.75kg/m2，BMI降低了2.7％。
■在日本人的MASLD和MetALD缓解中，减肥都起着重要作用。也就是说,针对特定的BMI降低是有效的。这强调了有针对性的体重管理策略在日本人群中预防和管理MASLD/MetALD的重要性。
这项回顾性观察研究包括8,707名日本MASLD/MetALD患者，他们从2015年5月至2023年3月接受了健康检查。在随后的访问中监测参与者的缓解情况。通过腹部超声检查并基于五种代谢异常中的至少一种来诊断MASLD。通过逻辑回归分析并使用受试者工作特征曲线评估体重指数（BMI）降低对MASLD/MetALD缓解的影响。
■Logistic回归分析显示，体重减轻与MASLD/MetALD缓解显著相关。在整个队列和男性患者中，包括运动习惯和饮酒减少在内的其他因素是MASLD/MetALD缓解的重要预测因素。MASLD/MetALD缓解的最佳BMI降低临界值为0.9kg/m2，在整个队列中降低4.0%，0.85公斤/平方米，男性减少3.9%，女性减少1.2公斤/平方米，减少4.5%。在BMI为23kg/m2的参与者中，临界值为0.75kg/m2，BMI降低了2.7％。
■在日本人的MASLD和MetALD缓解中，减肥都起着重要作用。也就是说,针对特定的BMI降低是有效的。这强调了有针对性的体重管理策略在日本人群中预防和管理MASLD/MetALD的重要性。
