■为了研究炎症因子之间的关系,如全血细胞计数(CBC)成分,中性粒细胞/淋巴细胞比率(NLR),单核细胞/淋巴细胞比率(MLR),血小板与淋巴细胞比率(PLR),和妊娠期糖尿病(GDM)。
■共纳入635名妊娠7-13周GDM孕妇和296名在产科接受产前检查的正常妊娠孕妇(2020年6月至2020年12月)。CBC参数,包括WBC,中性粒细胞,淋巴细胞(LYM),单核细胞(MON),红细胞(RBC),血红蛋白(HGB),平均红细胞体积(MCV),血小板(PLT),血小板积聚(PCT),平均血小板体积(MPV),NLR,MLR,PLR,丙氨酸转氨酶(ALT),天冬氨酸转氨酶(AST),γ-谷氨酰转移酶(GGT),和其他参数进行了评估。采用受试者工作特征(ROC)曲线分析各变量对GDM发生发展的筛选效应。
■血液中白细胞水平存在显著差异,NEU,LYM,MON,红细胞,HGB,PCT,ALT,AST,GGT,NLR,GDM组与对照组的MLR差异有统计学意义(P<0.05)。MON的诊断水平在所有因素中最高。
■炎症因子(WBC,NEU,LYM,MON,NLR,和MLR计数)与GDM相关。
UNASSIGNED: To investigate the association between inflammatory factors, such as complete blood count (CBC) components, neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), and gestational diabetes mellitus (GDM).
UNASSIGNED: A total of 635 pregnant women with GDM and 296 with normal pregnancies at 7-13 weeks of gestation who underwent prenatal examinations in the obstetrics department were enrolled (June 2020-December 2020). CBC parameters, including WBC, neutrophil, lymphocyte (LYM), monocyte (MON), red blood cell (RBC), hemoglobin (HGB), mean corpuscular volume (MCV), platelet (PLT), platelet accumulation (PCT), mean platelet volume (MPV), NLR, MLR, PLR, alanine transaminase (ALT), aspartate transaminase (AST), gamma-glutamyl transferase (GGT), and other parameters were assessed. The receiver operating characteristic (ROC) curve was used to analyze the screening effects of the variables on the development of GDM.
UNASSIGNED: There were significant differences in the blood levels of WBC, NEU, LYM, MON, RBC, HGB, PCT, ALT, AST, GGT, NLR, and MLR between the GDM and control groups (P<0.05). The diagnostic level of MON was the highest among all factors.
UNASSIGNED: Inflammatory factors (WBC, NEU, LYM, MON, NLR, and MLR counts) were correlated with GDM.