%0 Journal Article
%T Association of neutrophil/lymphocyte and platelet/lymphocyte ratios with inflammation and survival in Mexican patients on chronic hemodialysis.
%A Chávez Valencia V
%A Orizaga de la Cruz C
%A Lagunas-Rangel FA
%J Ther Apher Dial
%V 0
%N 0
%D 2024 Jun 7
%M 38845452
%F 2.195
%R 10.1111/1744-9987.14175
%X <B>BACKGROUND: </B>Neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) are markers of systemic inflammatory status. The relationship between NLR, PLR, and mortality is controversial among hemodialysis (HD) patients.<BR><B>OBJECTIVE: </B>Evaluate NLR and PLR in the prediction of mortality in chronic HD patients.<BR><B>METHODS: </B>We analyzed 130 patients with a follow-up for 66 months. Four groups were established according to NLR-PLR values. Kaplan-Meier curves and Cox proportional hazards analysis were used.<BR><B>RESULTS: </B>NLR-PLR correlated positively with C-reactive protein. Cox regression analysis for overall mortality among the four groups included age (HR 1.027, 95% CI 1.003-1.053) and albumin (HR 0.25, 95% CI 0.073-0.85). For cardiovascular (CV) mortality only pulse pressure differential (PPD) was included (HR 1.033; 95% CI 1.014-1.052). Low NLRs and high PLRs were associated with CV mortality (Log Rank test, p = 0.033).<BR><B>CONCLUSIONS: </B>Low NLRs and high PLRs predict the risk of CV mortality among HD patients.