背景:先前的研究已经证明了脂肪酸与神经系统疾病之间的关联。然而,没有研究检查血清脂肪酸水平与血清神经丝轻链(NfL)之间的关系,神经系统疾病的生物标志物。
目的:本研究旨在全面调查具有全国代表性的美国成年人样本中30种血清脂肪酸与血清NfL水平之间的复杂关系。利用2013-2014年全国健康和营养检查调查的数据。
方法:采用横截面分析,利用多元线性回归模型探讨30种血清脂肪酸与血清NfL水平之间的关系。此分析涉及对潜在混杂变量的调整,包括年龄,性别,种族,身体质量指数(BMI),吸烟状况,高脂血症,糖尿病,阐明血清脂肪酸和血清NfL水平之间的关系。
结果:分析显示某些脂肪酸与血清NfL水平有明显的相关性。值得注意的是,发现二十二烷酸(22:0)和三香酸(C23:0)与血清NfL水平呈负相关(β=-0.280,95%CI:-0.525,-0.035;β=-0.292,95%CI:-0.511,-0.072)。相反,棕榈油酸(16:1n-7)与血清NfL水平呈正相关(β=0.125,95%CI:0.027,0.222)。值得注意的是,即使在对潜在混杂因素进行校正后,这些关联仍然显著.
结论:某些饱和脂肪酸相对浓度高的个体表现出降低的血清NfL,而某些单不饱和脂肪酸相对浓度较高的患者血清NfL升高。这些发现有助于更深入地了解血清脂肪酸对NfL水平的潜在影响。在神经系统健康的背景下,为进一步的调查和潜在的干预措施提供了新的途径。
BACKGROUND: Previous studies have demonstrated associations between fatty acids and neurological disorders. However, no studies have examined the relationship between serum fatty acid levels and serum
neurofilament light chain (NfL), a biomarker of neurological disorders.
OBJECTIVE: This study aimed to comprehensively investigate the intricate relationship between 30 serum fatty acids and serum NfL levels in a nationally representative sample of United States adults, using data from the 2013-2014 National Health and Nutrition Examination Survey.
METHODS: Using a cross-sectional analysis, multivariable linear regression models were used to explore the associations between 30 serum fatty acids and serum NfL levels. This analysis involved adjustment for potential confounding variables, including age, sex, race, body mass index (BMI), smoking status, hyperlipidemia, and diabetes, to clarify the association between serum fatty acids and serum NfL levels.
RESULTS: The analysis revealed that certain fatty acids exhibited distinct associations with serum NfL levels. Notably, docosanoic acid (22:0) and tricosanoic acid (C23:0) were found to be inversely associated with serum NfL levels (β = -0.280, 95% confidence interval [CI]: -0.525, -0.035; β = -0.292, 95% CI: -0.511, -0.072). Conversely, palmitoleic acid (16:1n-7) demonstrated a positive association with serum NfL levels (β = 0.125, 95% CI: 0.027, 0.222). Notably, these associations remained significant even after adjustment for potential confounders.
CONCLUSIONS: Individuals with high relative concentrations of certain SFA exhibited decreased serum NfL, whereas those with high relative concentrations of certain monounsaturated fatty acids showed increased serum NfL. These findings contribute to a deeper understanding of the potential impact of serum fatty acids on NfL levels, shedding light on novel avenues for further investigation and potential interventions in the context of neurological health.