Abstract：
BACKGROUND: Although cadmium exposure had been demonstrated to be toxic to the nervous system, little was known about the link between cadmium exposure and axonal injury. Therefore, the present study aimed to reveal whether there was any correlation between blood cadmium and serum neurofilament light chain (NfL) levels in the general population.
METHODS: This study included 1040 participants with a median (IQR) age of 47 (35-60) years from the 2013-2014 National Health and Nutrition Examination Survey. Serum NfL levels were measured through immunoassay, and whole blood cadmium concentrations were detected by means of inductively coupled plasma mass spectrometry. Linear regression and restricted cubic spline model was applied to analyze the significance of relationship between blood cadmium and serum NfL levels.
RESULTS: In the full adjusted model, blood cadmium levels were found to be positively associated with serum NfL levels (Q4 vs Q1, β = 3.35, 95 %CI: 0.41, 6.30, p for trend = 0.014). A potential linear positive dose-effect relationship was discovered between blood cadmium and serum NfL levels (p for non-linearity = 0.15). According to the result of stratified analysis, the significant positive relationship between blood cadmium and serum NfL levels was present only in the population of middle-aged and older adults.
CONCLUSIONS: The present study suggested a positive association between blood cadmium and serum NfL levels in the general US population.
METHODS: This study included 1040 participants with a median (IQR) age of 47 (35-60) years from the 2013-2014 National Health and Nutrition Examination Survey. Serum NfL levels were measured through immunoassay, and whole blood cadmium concentrations were detected by means of inductively coupled plasma mass spectrometry. Linear regression and restricted cubic spline model was applied to analyze the significance of relationship between blood cadmium and serum NfL levels.
RESULTS: In the full adjusted model, blood cadmium levels were found to be positively associated with serum NfL levels (Q4 vs Q1, β = 3.35, 95 %CI: 0.41, 6.30, p for trend = 0.014). A potential linear positive dose-effect relationship was discovered between blood cadmium and serum NfL levels (p for non-linearity = 0.15). According to the result of stratified analysis, the significant positive relationship between blood cadmium and serum NfL levels was present only in the population of middle-aged and older adults.
CONCLUSIONS: The present study suggested a positive association between blood cadmium and serum NfL levels in the general US population.
摘要：
背景：尽管镉暴露已被证明对神经系统有毒，对镉暴露与轴突损伤之间的联系知之甚少。因此,本研究旨在揭示普通人群中血镉与血清神经丝轻链（NfL）水平是否存在相关性。
方法：这项研究包括来自2013-2014年国家健康和营养调查的1040名参与者，他们的中位年龄（IQR）为47（35-60）岁。通过免疫测定测定血清NfL水平，采用电感耦合等离子体质谱法检测全血镉浓度。应用线性回归和有限三次样条模型分析血镉与血清NfL水平的相关性。
结果：在完全调整模型中，血镉水平与血清NfL水平呈正相关(Q4vsQ1,β=3.35,95CI:0.41,6.30,趋势p=0.014)。在血镉和血清NfL水平之间发现了潜在的线性正剂量-效应关系（非线性p=0.15）。根据分层分析的结果，血镉与血清NfL水平之间存在显着正相关仅在中老年人群中存在。
结论：本研究提示在普通美国人群中血镉与血清NfL水平呈正相关。
方法：这项研究包括来自2013-2014年国家健康和营养调查的1040名参与者，他们的中位年龄（IQR）为47（35-60）岁。通过免疫测定测定血清NfL水平，采用电感耦合等离子体质谱法检测全血镉浓度。应用线性回归和有限三次样条模型分析血镉与血清NfL水平的相关性。
结果：在完全调整模型中，血镉水平与血清NfL水平呈正相关(Q4vsQ1,β=3.35,95CI:0.41,6.30,趋势p=0.014)。在血镉和血清NfL水平之间发现了潜在的线性正剂量-效应关系（非线性p=0.15）。根据分层分析的结果，血镉与血清NfL水平之间存在显着正相关仅在中老年人群中存在。
结论：本研究提示在普通美国人群中血镉与血清NfL水平呈正相关。
