■新诊断的多发性硬化症患者经常报告疲劳,疼痛,抑郁和焦虑。预防措施可能是有益的,但其有效性的证据有限,尤其是长期随访。
■该计划包括为期6个月的面对面干预(介绍性研讨会,以心理学为主导的小组会议和个人物理治疗),然后进行6个月的自我指导治疗。结果措施是在基线时采取的,6和12个月。主要结果指标是疲劳自我报告问卷,对生活和疾病接受度的满意度。次要结果是肺活量测定,肺活量参数和神经活性类固醇水平。
■从22名参与者中,17人完成了前6个月的随访,13人完成了随访。在运动和认知功能的疲劳量表上测量的疲劳在6个月(p=0.035)和随访(p=0.007)时显着降低。修正后的疲劳冲击量表(p=0.035)和生活满意度量表(p=0.007)在随访时显着增加。肺活量测定,肺活量参数,类固醇激素和神经活性类固醇水平没有显著变化.
■该方案可在12个月时持续改善,减轻患者组的疲劳并提高生活满意度。参与更频繁的人显示出更大的益处。
■本文描述了复杂的预防性干预对新诊断的多发性硬化症患者的影响。研究发现,该计划可以减少疲劳,并提高长期受益的生活满意度(在12个月的随访中)。参与频率较低的个人获得的收益较少。
UNASSIGNED: Newly diagnosed people with multiple sclerosis frequently report fatigue, pain, depression and anxiety. Preventative programmes may be beneficial, but there is limited evidence of their effectiveness, especially long-term follow-up.
UNASSIGNED: The programme consisted of 6-month face to face intervention (an introductory workshop, psychology-led group sessions and individual physical therapy) followed by 6-month self-guided therapy. Outcome measures were taken at baseline, 6 and 12 months. Primary outcomes measures were self-report questionnaires for fatigue, satisfaction with life and disease acceptance. Secondary outcomes were spirometry, spiroergometric parameters and neuroactive steroid levels.
UNASSIGNED: From 22 participants enrolled, 17 completed the first 6 months and 13 the follow-up. Fatigue measured on the Fatigue scale for motor and cognitive functions decreased significantly at 6 months (p = 0.035) and at follow-up (p = 0.007). The Modified Fatigue Impact Scale (p = 0.035) and Satisfaction With Life Scale (p = 0.007) significantly increased at follow-up. Spirometry, spiroergometric parameters, steroid hormones and neuroactive steroids levels did not change significantly.
UNASSIGNED: This programme reduces fatigue and improves satisfaction with life in this patient group with improvements sustained at 12 months. People who participated more frequently showed greater benefit.
UNASSIGNED: The paper describes the effects of a complex preventative intervention for people with newly diagnosed Multiple Sclerosis. The study found that this programme reduces fatigue and improves satisfaction with life with long-term benefit (at 12-month follow up). The individuals who participated less frequently experienced fewer benefits.