魔芋葡甘聚糖(KGM)作为一种新兴的天然聚合物,由于其成膜性,优异的凝胶化,无毒特性,附着力强,良好的生物相容性,和易于生物降解。受益于这些优越的性能,KGM已广泛应用于多种复合材料的构造中,以进一步提高其固有性能(例如,机械强度和性能)。到目前为止,KGM基复合材料在各个领域得到了广泛的应用,尤其是在生物医学领域。因此,及时回顾相关研究进展,对于促进KGM基复合材料的发展具有重要意义。创新,首先,本文从生物医学领域的独特视角,简要介绍了KGM的结构特性和功能。然后,KGM基复合材料的制备和性能的最新进展(即,凝胶,微球,电影,纳米纤维,纳米粒子,等。)进行了全面总结。最后,全面总结和讨论了KGM基复合材料在生物医学领域的应用前景,涉及药物输送,伤口愈合,组织工程,抗菌,肿瘤治疗,等。令人印象深刻的是,提出了这一充满希望的领域中剩余的挑战和机遇。该综述可为指导和促进KGM基复合材料的设计和生物医学应用提供参考。
Konjac glucomannan (KGM) as an emerging natural polymer has attracted increasing interests owing to its film-forming properties, excellent gelation, non-toxic characteristics, strong adhesion, good biocompatibility, and easy biodegradability. Benefiting from these superior performances, KGM has been widely applied in the construction of multiple composite materials to further improve their intrinsic performances (e.g., mechanical strength and properties). Up to now, KGM-based composite materials have obtained widespread applications in diverse fields, especially in the field of biomedical. Therefore, a timely review of relevant research progresses is important for promoting the development of KGM-based composite materials. Innovatively, firstly, this review briefly introduced the structure properties and functions of KGMs based on the unique perspective of the biomedical field. Then, the latest advances on the preparation and properties of KGM-based composite materials (i.e., gels, microspheres, films, nanofibers, nanoparticles, etc.) were comprehensively summarized. Finally, the promising applications of KGM-based composite materials in the field of biomedical are comprehensively summarized and discussed, involving drug delivery, wound healing, tissue engineering, antibacterial, tumor treatment, etc. Impressively, the remaining challenges and opportunities in this promising field were put forward. This review can provide a reference for guiding and promoting the design and biomedical applications of KGM-based composites.