■甲折视频毛细管镜检查(NVC)是一个简单的,非侵入性诊断工具,但很少有健康儿童毛细血管密度正常值的研究。种族背景似乎在毛细血管密度中起作用;然而,这还没有得到很好的证实。在这项工作中,我们着手评估种族背景/皮肤色素沉着和年龄对健康儿童毛细血管密度读数的影响.次要目的是调查同一患者的不同手指之间的密度是否存在显着差异。
■在2016年至2021年之间,接触了来自AUMC周围学校的健康儿童,通过方便的抽样。在这项横断面研究中,在一次性视频镜检查(×200倍放大)中获得毛细血管镜图像,以解决毛细血管密度(即远端行中每线性毫米的毛细管数量)。这个参数与年龄比较,性别,种族,皮肤色素等级(I-III)和八个不同的手指之间,不包括拇指。通过ANOVA比较密度差异。毛细血管密度与年龄之间的相关性用Pearson相关性计算。
■我们调查了145名健康儿童,平均年龄为11.03岁(SD3.51)。毛细管密度的范围为每毫米4-11个毛细管。我们观察到II级的毛细血管密度较低(6.4±0.5cap/mm,P<0.001)和“III级”(5.9±0.8cap/mm,P<0.001),与“I级”组相比(7.0±0.7cap/mm)。在整个组中,我们没有发现年龄和密度之间的显着相关性。与其他手指相比,两侧的第五个手指具有显著更低的密度。
■皮肤色素沉着程度较高的健康儿童<18岁,其指甲毛细血管密度明显降低。在具有非洲/非洲/加勒比和北非/中东种族的主题中,与高加索种族的受试者相比,观察到平均毛细血管密度显著较低(分别为P<0.001和P<0.05.其他种族之间没有显着差异。年龄和毛细血管密度之间没有相关性。与其他手指相比,双手的第五个手指显示出较低的毛细血管密度。在描述患有结缔组织疾病的儿科患者的低密度时,需要考虑到这一点。
UNASSIGNED: Nailfold video capillaroscopy (NVC) is a simple, non-invasive diagnostic tool but studies with normal values for capillary density in healthy children are rare. Ethnic background seems to play a role in capillary density; however, this is not well substantiated yet. In this work, we set out to evaluate influence of ethnic background/skin pigmentation and age on capillary density reading in healthy children. Secondary aim was to investigate whether there is a significant difference in density between different fingers within the same patient.
UNASSIGNED: Between 2016 and 2021, healthy children from schools around AUMC were approached, by convenience sampling. In this cross-sectional study, capillaroscopic images were obtained in a one-time videocapillaroscopy (×200 magnification) addressing the capillary density (i.e., number of capillaries per linear millimetre in the distal row). This parameter was compared to age, sex, ethnicity, skin pigment grade (I-III) and between eight different fingers, excluding the thumbs. Density differences were compared by ANOVAs. Correlations between capillary density and age were calculated with Pearson correlations.
UNASSIGNED: We investigated 145 healthy children with mean age of 11.03 years (SD 3.51). The range of capillary density was 4-11 capillaries per millimetre. We observed a lower capillary density in the \'grade II\' (6.4±0.5 cap/mm, P<0.001) and \'grade III\' (5.9±0.8 cap/mm, P<0.001) pigmented-classified groups compared to the \'grade I\' group (7.0±0.7 cap/mm). We did not find a significant correlation between age and density in the overall group. The fifth fingers on both sides had a significantly lower density compared to the other fingers.
UNASSIGNED: Healthy children <18 years with higher degree of skin pigmentation show a significantly lower nailfold capillary density. In subjects with an African/Afro-Caribbean and North-African/Middle-Eastern ethnicity, a significantly lower mean capillary density was observed compared to subjects with the Caucasian ethnicity (P<0.001, and P<0.05, respectively. There were no significant differences between other ethnicities. No correlation was found between age and capillary density. The fifth fingers on both hands displayed lower capillary density compared to the other fingers. This needs to be taken into account when describing lower density in paediatric patients with connective tissue diseases.