OBJECTIVE: To define and standardize age-specific normal NVC patterns in healthy children and adolescents.
METHODS: A cross-sectional observational multicentric study was conducted in 564 participants aged 5-17 years. Dino-Lite CapillaryScope 200 Pro Model MEDL4N Pro was performed at 200× magnification. Quantitative and qualitative NVC parameters were analyzed separately for each age group and divided into 4 groups based on age categories.
RESULTS: Of the 564 healthy participants, 54.9% were female. A total of 1184 images and 3384 capillaries were analysed. Positive correlations were observed between age and capillary density (p < 0.001, R = 0.450, CI95% 0.398-0.503). There was also a positive correlation between age and arterial/venous, loop diameter and capillary length, whereas there was a weak negative correlation between intercapillary distance. However, no correlation was found between age and capillary width. In addition, capillary density was significantly lower in 5-7 age group compared to the other patient groups. Arterial limb diameter was lower in 5-7 age group, while venous limb diameter was significantly wider in 15-17 age group compared to the other patient groups. Dilated capillaries (8.7%), capillary tortuosity (14.4%), crossed capillaries (43.1%), micro-haemorrhages (2.7%), avascular area (4.8%) were present in all age groups. Excellent intra- and interobserver ICC values were obtained for all parameters.
CONCLUSIONS: These findings hold potential significance for future studies, aiding in the analysis and differentiation of children suspected of rheumatological diseases with potential microangiopathy.
目的:定义和标准化健康儿童和青少年的年龄特异性正常NVC模式。
方法:在564名5-17岁的参与者中进行了一项横断面观察性多中心研究。Dino-LiteCapillaryScope200Pro型号MEDL4NPro在200倍放大倍数下进行。对每个年龄组的NVC参数分别进行定量和定性分析,并根据年龄类别分为4组。
结果:在564名健康参与者中,54.9%为女性。共分析了1184张图像和3384个毛细血管。年龄与毛细血管密度呈正相关(p<0.001,R=0.450,CI95%0.398-0.503)。年龄与动脉/静脉之间也存在正相关,环直径和毛细管长度,而毛细管间距离之间存在弱负相关。然而,年龄与毛细血管宽度无相关性.此外,与其他患者组相比,5~7岁组的毛细血管密度显著降低.5-7岁组动脉直径较低,而与其他患者组相比,15-17岁年龄组的静脉肢体直径明显更宽。毛细血管扩张(8.7%),毛细血管弯曲度(14.4%),交叉毛细血管(43.1%),微出血(2.7%),所有年龄组均存在无血管面积(4.8%).对于所有参数,均获得了出色的观察者内和观察者间ICC值。
结论:这些发现对未来的研究具有潜在的意义。协助分析和鉴别怀疑患有潜在微血管病变的风湿病儿童。