UNASSIGNED:研究与乙型肝炎或丙型肝炎病毒(HBV或HCV)相关的肝硬化相比,中年(40-59岁)和老年(≥60岁)患者非酒精性脂肪性肝病(NAFLD)的危险因素的患病率。
UNASSIGNED:在2013年8月至2014年12月之间,前瞻性招募了40岁以上的病例(隐源性肝硬化)和对照(HBV/HCV肝硬化),并评估了NAFLD的病因和患病率。
UNASSIGNED:纳入118例(男性-74%;年龄55(40-74)岁;中位数(范围);儿童A级:B:C-46:38:16)和59名对照(男性-80%;年龄55.5(40-69)岁;儿童A级:B:C-56:30:14)。肥胖(53%v/s39%,P-0.081),糖尿病(DM)(52%v/s27%;P-0.002),DM家族史(30%v/s13%;P-0.016),肥胖家族史(21%v/s3.5%;P-0.002)和代谢综合征(65%v/s44%;P-0.01)高于对照组.肥胖患者的终生体重也比对照组长(5.9±6.2岁v/s3.2±5.1岁,P-0.002)。关于子群分析,在老年群体中,DM(55%v/s17%,P-0.006),DM家族史(40%v/s11%,P-0.025),代谢综合征(76%v/s44%,与对照组相比,P-0.017)和肥胖家族史(19%v/s0,P-0.047)在病例中更常见,就像中年人一样,肥胖家族史是唯一的显著因素(22%v/s5%,P-0.025)。在中老年人群中,肥胖的终生体重比对照组更长。
未经证实:在中老年肝硬化患者中,在隐源性肝硬化患者中,NAFLD的危险因素患病率较高,与HBV或HCV肝硬化相比。
UNASSIGNED: To study the prevalence of risk factors for nonalcoholic fatty liver disease (NAFLD) in middle-aged (40-59 years) and elderly patients (≥60 years) with cryptogenic cirrhosis as compared to those with hepatitis B or C virus (HBV or HCV) related cirrhosis.
UNASSIGNED: Between August 2013 and December 2014, cases (cryptogenic cirrhosis) and controls (HBV/HCV cirrhosis) above 40 years of age were prospectively recruited and assessed for the cause and prevalence of risk factors for NAFLD.
UNASSIGNED: One hundred eighteen cases (male-74%; age 55 (40-74) years; median (range); Child\'s class A:B:C-46:38:16) and 59 controls (male-80%; age 55.5 (40-69) years; Child\'s class A:B:C-56:30:14) were enrolled. Obesity (53% v/s 39%, P-0.081), diabetes mellitus (DM) (52% v/s 27%; P-0.002), family history of DM (30% v/s 13%; P-0.016), family history of Obesity (21% v/s 3.5%; P-0.002) and metabolic syndrome (65% v/s 44%; P-0.01) were more among cases than controls. Lifetime weight as obese was also longer in cases than in controls (5.9 ± 6.2 years v/s 3.2 ± 5.1 years, P-0.002). On subgroup analysis, in elderly age group, DM (55% v/s 17%, P-0.006), family history of DM (40% v/s 11%, P-0.025), metabolic syndrome (76% v/s 44%, P-0.017) and family history of obesity (19% v/s 0, P-0.047) were more common in cases as compared to controls, where as in the middle-age group, family history of obesity was the only significant factor (22% v/s 5%, P-0.025). Lifetime weight as obese was longer in cases than controls in both middle and elderly age groups.
UNASSIGNED: Among middle-aged and elderly patients with cirrhosis, there was a higher prevalence of risk factors for NAFLD in those with cryptogenic cirrhosis, compared to those with HBV or HCV cirrhosis.