全国数据集经常用于检查美国的癌症趋势和结果,了解常用监测的优势和局限性,流行病学,在设计研究和解释结果时,最终结果(SEER)计划和国家癌症数据库(NCDB)很重要。我们使用结直肠癌(CRC)作为案例研究来比较可用的信息。我们确定了2004年至2021年间诊断为CRC的575,128名(SEER)和1,578,046名(NCDB)成年人。年龄的分布,肿瘤位置,舞台,SEER和NCDB之间的治疗没有显著差异。SEER代表种族和种族不同的人群,包括较高比例的西班牙裔(11.7%vs5.8%)和亚洲/太平洋岛民(8.6%vs3.3%)。SEER包括更多关于区域级特征的信息,例如县级贫困措施,失业,以及移民和人口普查道一级的社会经济地位衡量标准。年龄调整后的发病率,死亡率,和特定原因的生存只有在SEER,促进对种族的详细分析,民族,以及癌症发病率和死亡率的社会经济差异。NCDB提供SEER无法提供的肿瘤特征和治疗信息,包括微卫星不稳定,KRAS突变,姑息治疗,计划外再入院,手术后30天死亡率,促进对治疗效果和结果的分析。SEER(55.6%)与NCDB(57.5%)的5年总生存率相似。
Nationwide datasets are frequently used to examine cancer trends and outcomes in the U.S. Understanding the strengths and limitations of the commonly used Surveillance, Epidemiology, and End Results (SEER) Program and the National Cancer Database (
NCDB) is important when designing studies and interpreting results. We used colorectal cancer (CRC) as a case study to compare information available. We identified 575,128 (SEER) and 1,578,046 (
NCDB) adults diagnosed with CRC between 2004 and 2021. The distribution of age, tumor location, stage, and treatment did not meaningfully differ between SEER and
NCDB. SEER represents racially and ethnically diverse populations, including a higher proportion of Hispanic (11.7% vs 5.8%) and Asian/Pacific Islander (8.6% vs 3.3%) persons. SEER includes more information on area-level characteristics, such as county-level measures of poverty, unemployment, and migration and census tract-level measures of socioeconomic status. Age-adjusted incidence, mortality rates, and cause-specific survival are only available in SEER, facilitating detailed analyses of racial, ethnic, and socioeconomic differences in cancer incidence and mortality.
NCDB provides information on tumor characteristics and treatment not available in SEER, including microsatellite instability, KRAS mutation, palliative treatment, unplanned readmissions, and 30-day mortality after surgery, facilitating analyses of treatment effectiveness and outcomes. Five-year overall survival was similar in SEER (55.6%) vs
NCDB (57.5%).