Abstract：
BACKGROUND: The current research on geriatric patients with spinal chondrosarcoma is limited. This study aimed to investigate the demographics, patterns of care, and survival of geriatric patients with chondrosarcoma of the mobile spine.
METHODS: The National Cancer Database was queried from 2008 to 2018 for geriatric patients (60-89 years) with chondrosarcoma of the mobile spine. The primary outcome of this study was overall survival (OS). The secondary outcome was treatment utilization patterns. Survival analyses were conducted using log-rank tests and Cox proportional hazards regressions. Logistic regression models were utilized to assess correlations between baseline variables and treatment utilization.
RESULTS: The database retrieved 122 patients. While 43.7% of the patients presented with tumors exceeding 5cm in size, the incidence of regional lymph node involvement or distant metastases was relatively low, affecting only 5% of the patients. Furthermore, 22.3% of the patients had tumors graded as 3-4. The five-year OS rate was 52.9% (95% confidence interval 42-66.6). The mortality risk was significantly associated with age, tumor grade and stage, and treatment plan. Most patients (79.5%) underwent surgery, while 35.9% and 4.2% were treated with radiotherapy and chemotherapy, respectively. Age, race, comorbidities, geographical region, tumor stage, and healthcare facility type significantly correlated with treatment utilization.
CONCLUSIONS: Surgical resection significantly lowered the mortality risk in geriatric patients with spinal chondrosarcomas. Demographic and geographical factors significantly dictated treatment plans. Further studies are required to assess the role of radiotherapy and chemotherapy in treating these patients in the modern era.
METHODS: The National Cancer Database was queried from 2008 to 2018 for geriatric patients (60-89 years) with chondrosarcoma of the mobile spine. The primary outcome of this study was overall survival (OS). The secondary outcome was treatment utilization patterns. Survival analyses were conducted using log-rank tests and Cox proportional hazards regressions. Logistic regression models were utilized to assess correlations between baseline variables and treatment utilization.
RESULTS: The database retrieved 122 patients. While 43.7% of the patients presented with tumors exceeding 5cm in size, the incidence of regional lymph node involvement or distant metastases was relatively low, affecting only 5% of the patients. Furthermore, 22.3% of the patients had tumors graded as 3-4. The five-year OS rate was 52.9% (95% confidence interval 42-66.6). The mortality risk was significantly associated with age, tumor grade and stage, and treatment plan. Most patients (79.5%) underwent surgery, while 35.9% and 4.2% were treated with radiotherapy and chemotherapy, respectively. Age, race, comorbidities, geographical region, tumor stage, and healthcare facility type significantly correlated with treatment utilization.
CONCLUSIONS: Surgical resection significantly lowered the mortality risk in geriatric patients with spinal chondrosarcomas. Demographic and geographical factors significantly dictated treatment plans. Further studies are required to assess the role of radiotherapy and chemotherapy in treating these patients in the modern era.
摘要：
背景：目前对老年脊髓软骨肉瘤患者的研究有限。本研究旨在调查人口统计学，护理模式，和老年患者的生存活动脊柱软骨肉瘤。
方法：从2008年至2018年，国家癌症数据库查询了患有可移动脊柱软骨肉瘤的老年患者（60-89岁）。这项研究的主要结果是总生存期（OS）。次要结果是治疗利用模式。使用对数秩检验和Cox比例风险回归进行生存分析。使用Logistic回归模型来评估基线变量与治疗利用率之间的相关性。
结果：数据库检索到122名患者。虽然43.7％的患者表现出超过5cm的肿瘤，区域淋巴结受累或远处转移的发生率相对较低，仅影响5%的患者。此外，22.3%的患者肿瘤分级为3-4级。五年OS率为52.9%(95%置信区间42-66.6)。死亡风险与年龄显著相关，肿瘤分级和分期，和治疗计划。大多数患者（79.5%）接受了手术，而35.9%和4.2%的患者接受了放疗和化疗，分别。年龄,种族,合并症,地理区域,肿瘤分期,医疗机构类型与治疗利用率显著相关。
结论：手术切除可显著降低老年脊髓软骨肉瘤患者的死亡风险。人口统计学和地理因素显著决定了治疗计划。需要进一步的研究来评估放疗和化疗在现代治疗这些患者中的作用。
方法：从2008年至2018年，国家癌症数据库查询了患有可移动脊柱软骨肉瘤的老年患者（60-89岁）。这项研究的主要结果是总生存期（OS）。次要结果是治疗利用模式。使用对数秩检验和Cox比例风险回归进行生存分析。使用Logistic回归模型来评估基线变量与治疗利用率之间的相关性。
结果：数据库检索到122名患者。虽然43.7％的患者表现出超过5cm的肿瘤，区域淋巴结受累或远处转移的发生率相对较低，仅影响5%的患者。此外，22.3%的患者肿瘤分级为3-4级。五年OS率为52.9%(95%置信区间42-66.6)。死亡风险与年龄显著相关，肿瘤分级和分期，和治疗计划。大多数患者（79.5%）接受了手术，而35.9%和4.2%的患者接受了放疗和化疗，分别。年龄,种族,合并症,地理区域,肿瘤分期,医疗机构类型与治疗利用率显著相关。
结论：手术切除可显著降低老年脊髓软骨肉瘤患者的死亡风险。人口统计学和地理因素显著决定了治疗计划。需要进一步的研究来评估放疗和化疗在现代治疗这些患者中的作用。
