酒精宿醉(veisalgia)是一个相当普遍的现象。肌动痛的发病机制尚不清楚,治疗方法尚未确定。偶尔,学生在酗酒前服用N-乙酰半胱氨酸(NAC)以减轻宿醉。这项研究的目的是评估NAC对血清电解质水平的影响,酶,暴饮暴食中的氧化应激生物标志物和veisalgia症状。在这个随机的,双盲,安慰剂对照研究,健康学生被随机分为两组:一组接受NAC治疗,另一组接受安慰剂治疗.在饮酒前采集血样,在1.5小时的长时间饮酒后30分钟,和随后的早晨。血清电解质水平,尿素,酶,乙醇,测定8-羟基脱氧鸟苷(8-OHdG)和N-ε-己酰基-赖氨酸。参与者根据症状完成了急性宿醉严重程度量表(AHSS)评估,和40名学生(20名男性),年龄23±2岁,包括在研究中。他们的平均血液乙醇浓度为1.4g/kg。饮酒后血清钠水平升高,与饮用前相比,两组的尿素和尿素在第二天早晨下降。饮酒后血清8-OHdG水平升高,并一直升高到第二天早晨,与饮酒前的水平相比,在两组中。NAC对钠没有影响,尿素和8-OHdG水平或神经痛的症状。总之,暴饮暴食会导致血清钠的短暂增加,并导致氧化标志物8-OHdG水平的长期增加。NAC对钠和8-OHdG水平没有影响。
Alcohol hangover (veisalgia) is a fairly common phenomenon. The pathogenesis of veisalgia is not understood and treatment has not yet been established. Occasionally, students take N-acetylcysteine (
NAC) before binge drinking to alleviate hangover. The aim of this study was to evaluate the effect of
NAC on serum levels of electrolytes, enzymes, oxidative stress biomarkers and symptoms of veisalgia in binge drinking. In this randomized, double-blind, placebo-controlled study, healthy students were randomly assigned into two groups: one receiving
NAC and the other receiving a placebo. Blood samples were taken before drinking, 30 min after a 1.5 h long drinking session, and the subsequent morning. Serum levels of electrolytes, urea, enzymes, ethanol, 8-Hydroxydeoxyguanosine (8-OHdG) and N-epsilon-hexanoyl-lysine were measured. The participants completed the Acute Hangover Severity Scale (AHSS) assessment based on symptoms, and 40 students (20 male), aged 23 ± 2 years, were included in the study. Their mean blood ethanol concentration was 1.4 g/kg. Serum sodium levels were increased after drinking, and urea decreased the following morning compared to their levels before drinking in both groups. Serum 8-OHdG levels were increased after drinking and remained elevated until the following morning, compared to the levels before drinking, in both groups.
NAC had no effect on sodium, urea and 8-OHdG levels or the symptoms of veisalgia. In conclusion, binge drinking causes a transient increase in serum sodium and as a prolonged increase in oxidative marker 8-OHdG levels.
NAC had no effect on the sodium and 8-OHdG levels.