背景:这篇综述旨在研究临床特征,诊断结果,治疗,和COVID-19感染后异位骨化患者的结局。
方法:使用MEDLINE/Pubmed,全球卫生,和Scopus数据库(1月12日,2023),包括来自任何国家和语言的所有病例报告和病例系列。纳入本综述的标准是随后发生异位骨化的COVID-19感染病例。
结果:本系统评价分析了15例报告(n=20例患者),记录了COVID-19感染后异位骨化的病例。80%的患者为男性,平均年龄为59岁。所有患者都需要在重症监护病房住院,平均住院时间为48.5天。所有患者都需要机械通气,其中30%接受了气管造口术。常见症状包括僵硬和疼痛,最常影响多个地点(70%),臀部和肩膀主要受累。X射线是最常用的成像方式,其次是计算机断层扫描。虽然进行了治疗,一些患者继续出现症状,特别是刚度。
结论:已经报道了20例COVID-19后发生异位骨化的患者,其中大多数至少有两个独立的危险因素。因此,这两个临床实体之间的联系是不确定的,需要进一步调查。尽管如此,怀疑严重COVID-19感染患者的异位骨化仍然很重要,长时间的固定,机械通气,他们会出现关节疼痛和僵硬,因为这种情况会显著影响患者的生活质量。
背景:CRD42023393516。
BACKGROUND: This review aims to study the clinical characteristics, diagnostic results, treatments, and outcomes in patients with heterotopic ossification following COVID-19 infection.
METHODS: A literature search for eligible articles was conducted using MEDLINE/Pubmed, Global Health, and Scopus databases (January 12th, 2023), including all case reports and case series from any country and language. The criteria for inclusion in this review were cases of COVID-19 infection subsequently developing heterotopic ossification.
RESULTS: This systematic review analysed 15 reports (n = 20 patients) documenting cases of heterotopic ossification following COVID-19 infection. 80% of the patients were male, with a median age of 59 years. All patients required intensive care unit stay with an average duration of 48.5 days. Mechanical ventilation was necessary for all patients and 30% of them underwent tracheostomy. Common symptoms included stiffness and pain, most frequently affecting multiple locations (70%), with the hips and shoulders being predominantly involved. X-rays were the most commonly used imaging modality, followed by computed tomography. Although treatment was given, some of the patients continued to experience symptoms, particularly stiffness.
CONCLUSIONS: 20 patients who developed heterotopic ossification after COVID-19 have been reported, the majority of which had at least two independent risk factors for this condition. The link between those two clinical entities is therefore uncertain, requiring further investigation. It is nonetheless important to suspect heterotopic ossification in patients with severe COVID-19 infection, prolonged immobilisation, mechanical ventilation, who develop joint pain and stiffness, as this condition can significantly impact patients\' quality of life.
BACKGROUND: CRD42023393516.