PDF(Pubmed)
Abstract：
Positron emission tomography/computed tomography (PET/CT) using 18F-fluorodeoxyglucose ([18F]-FDG) is a widely adopted imaging modality for detecting hypermetabolic lesions. However, emerging positron-emitting tracers, such as radiopharmaceuticals featuring fibroblast activation protein (FAP) inhibitors (FAPI) labeled with [18F] or [68Ga], have opened new avenues in nuclear medicine. This case report focuses on the unique behavior of [68Ga]-FAPI in bilateral gluteal myositis ossificans, an infrequent condition characterized by soft tissue ossification. A 45-year-old woman with gastric adenocarcinoma underwent subtotal gastrectomy and received neoadjuvant and adjuvant chemotherapy; [68Ga]-FAPI PET revealed metastatic processes and unexpected [68Ga]-FAPI avid intramuscular ossifications in the pelvic and bilateral thigh muscles. Even though there was no history of trauma, the patient was diagnosed with myositis ossificans, a condition marked by non-cancerous ectopic ossifications. Diagnosis relies on history, radiology, and/or histology. FAPI imaging, increasingly used for inflammatory and infectious diseases, can exhibit uptake in benign conditions, including those involving bones and joints. This case report is the first to document incidental bilateral [68Ga]-FAPI uptake in bilateral gluteal myositis ossificans. The robust [68Ga]-FAPI activity in myositis ossificans highlights the importance of considering myositis ossificans in the context of soft tissue calcifications with intense [68Ga]-FAPI uptake.
摘要：
使用18F-氟脱氧葡萄糖（[18F]-FDG）的正电子发射断层扫描/计算机断层扫描（PET/CT）是一种广泛采用的用于检测高代谢病变的成像方式。然而,新兴的发射正电子的示踪剂，例如以[18F]或[68Ga]标记的成纤维细胞活化蛋白（FAP）抑制剂（FAPI）为特征的放射性药物，为核医学开辟了新的途径.该病例报告集中于[68Ga]-FAPI在双侧臀肌炎骨化症中的独特行为，以软组织骨化为特征的罕见病症。一名45岁的胃腺癌妇女接受了胃大部切除术，并接受了新辅助和辅助化疗；[68Ga]-FAPIPET显示出盆腔和双侧大腿肌肉的转移过程和意外的[68Ga]-FAPI肌肉骨化。尽管没有外伤史,病人被诊断为骨化性肌炎,以非癌性异位骨化为特征的病症。诊断依赖于病史,放射学,和/或组织学。FAPI成像，越来越多地用于炎症和传染病，可以在良性条件下表现出摄取，包括涉及骨骼和关节的。该病例报告是第一个记录双侧臀肌炎骨化性的双侧[68Ga]-FAPI摄取的病例。强健的[68Ga]-FAPI活性在骨化性肌炎中突出了在软组织钙化伴强烈的[68Ga]-FAPI摄取的背景下考虑骨化性肌炎的重要性。
