■在动脉高血压中观察到心房颤动(AF),心力衰竭,缺血性心脏病,和肺部病理学,特别是,慢性阻塞性肺疾病(COPD)。COPD又是发展这些心血管疾病和各种心律失常的危险因素。在冠状病毒病(COVID)的情况下,这类合并症患者是最脆弱的群体,有很高的不良结局风险.COPD与冠状病毒感染之间的相关性通过临床和病理生理表现的相似性来解释,在诊断和确定合理治疗方面造成更多困难。本研究的目的是探讨COPD在房颤发病和进展中的作用。特别是在COVID-19的情况下。
我们搜索了PubMed数据库,并纳入了COPD和AF共病患者的研究,以及COVID-19背景下的类似患者。
■提出了关于COPD和AF共病问题的现代观点。在存在心肺合并症的情况下,观察到临床病程相互恶化的症状,由于发病机制的某些联系的共性,包括缺氧,血流动力学紊乱,激活交感神经肾上腺系统,全身性炎症,和纤维化的发展,导致心肌重塑,治疗效果的下降,预后恶化,特别是在COVID-19的背景下。
■介绍了对COPD中AF的发病机制和病程特征的研究结果,以及在COVID-19大流行背景下这种共病病理的形成和进展。
UNASSIGNED: Atrial fibrillation (AF) is observed in arterial hypertension, heart failure, ischemic heart disease, and pulmonary pathology, particularly, chronic obstructive pulmonary disease (COPD). COPD in turn is a risk factor for developing these cardiovascular diseases and various arrhythmias. In the coronavirus disease (COVID) situation, such comorbid patients are the most vulnerable group with a high risk of adverse outcomes. The relevance of the relationship between COPD and coronavirus infection is explained by the similarity of clinical and pathophysiological manifestations, creating more difficulties in diagnosing and determining rational treatment. The aim of the current study is to explore the role COPD plays in the onset and progression of AF, especially in the situation of COVID-19.
UNASSIGNED: We searched PubMed databases and included studies with information on comorbid patients suffering from COPD and AF, as well as similar patients in the context of COVID-19.
UNASSIGNED: A modern view on the problem of comorbidity of COPD and AF is presented. In the presence of cardiorespiratory comorbidity, symptoms of mutual worsening of the clinical course are observed, due to the commonality of some links of pathogenesis, including hypoxia, hemodynamic disturbances, activation of the sympathoadrenal system, systemic inflammation, and development of fibrosis, leading to myocardial remodeling, a decrease in the effectiveness of the therapy, and a worsening prognosis, especially in the context of COVID-19.
UNASSIGNED: The results of a study of the features of the pathogenesis and course of AF in COPD are presented, as well as the formation and progression of this comorbid pathology in the context of the COVID-19 pandemic.