背景:光生物调节,也称为低水平光疗法(LLLT),已经成为一种有希望的瘙痒干预措施,一种普遍且经常令人痛苦的症状。
目的:本研究调查了低水平光疗(LLLT)缓解瘙痒的疗效,过度兴奋,以及组胺和毛藻引起的异源性疾病。
方法:在双盲中,随机化,具有分裂体设计的假对照试验,健康志愿者在不同的上背部象限接受了6分钟的LLLT和假治疗.组胺模型应用于上象限,和Mucunapruriens到下象限。瘙痒强度,同种异体,过度兴奋,火炬区,治疗前后测量皮肤温度。
结果:17个人(8名女性,9名男性)参与了这项研究。在组胺模型中,LLLT显着降低瘙痒强度(差异=13.9(95%CI:10.5-17.4),p=0.001),同种异体(差异=0.80(95%CI:0.58-1.02),p=0.001),和过度(差异=0.48(95%CI:0.09-0.86),p=0.01)。皮肤温度变化在两组之间没有显着差异(差异=-2.0(95%CI:-6.7-2.6),p=0.37)。对于Mucunapruriens模型,在任何测量中都没有观察到显著差异,包括瘙痒强度(差异=0.8(95%CI:-2.3-3.8),p=0.61)夸大(差异=0.08(95%CI:-0.06-0.33),p=0.16)和同种异体(差异=0。0.09(95%CI:-0.08-0.256),p=0.27)。
结论:LLLT可有效减少组胺诱导的瘙痒,同种异体,和过度行为;然而,LLLT对Mucunapruriens引起的瘙痒无效。需要进一步的研究来确定LLLT在各种瘙痒模型中的有效性。
BACKGROUND: Photobiomodulation, also referred to as Low-Level Light Therapy (LLLT), has emerged as a promising intervention for pruritus, a prevalent and often distressing symptom.
OBJECTIVE: This study investigated the efficacy of low-level light therapy (LLLT) in alleviating pruritus, hyperknesis, and alloknesis induced by histamine and
Mucuna pruriens.
METHODS: In a double-blind, randomized, sham-controlled trial with a split-body design, healthy volunteers underwent 6 minutes of LLLT and sham treatments in separate upper back quadrants. The histamine model was applied to the upper quadrants, and
Mucuna pruriens to the lower quadrants. Pruritus intensity, alloknesis, hyperknesis, flare area, and skin temperature were measured pre and post treatment.
RESULTS: Seventeen individuals (eight females, nine males) participated in the study. In the histamine model, LLLT notably reduced itch intensity (difference = 13.9 (95% CI: 10.5 - 17.4), p = 0.001), alloknesis (difference = 0.80 (95% CI: 0.58-1.02), p = 0.001), and hyperknesis (difference = 0.48 (95% CI: 0.09-0.86), p = 0.01). Skin temperature changes were not significantly different between the two groups (difference = -2.0 (95% CI: -6.7-2.6), p = 0.37). For the
Mucuna pruriens model, no significant differences were observed in any measures, including itch intensity (difference = 0.8 (95% CI: -2.3 - 3.8), p = 0.61) hyperknesis (difference = 0.08 (95% CI: -0.06-0.33), p = 0.16) and alloknesis (difference = 0. 0.09 (95% CI: -0.08-0.256), p = 0.27).
CONCLUSIONS: LLLT effectively reduced histamine-induced pruritus, alloknesis, and hyperknesis; however, LLLT was ineffective against
Mucuna pruriens-induced pruritus. Further investigations are required to determine LLLT\'s effectiveness of LLLT in various pruritus models.