背景:(-)-Fenchone是一种天然存在的单萜,存在于FoeniculumvulgareMill的精油中。,刺槐L.,和PeumusboldusMolina.药理学研究报告了它的抗伤害感受,抗菌,抗炎,止泻药,和抗氧化活性。
方法:通过口服预处理在半胱胺诱导的十二指肠损伤模型中评估(-)-芬酮的预防性抗溃疡作用。胃愈合,潜在的机制,使用口服给药14天的乙酸诱导的胃溃疡大鼠模型评估重复给药后的毒性。
结果:在半胱胺诱导的十二指肠溃疡模型中,芬酮(37.5-300mg/kg)显着减少了溃疡面积并防止了病变的形成。在乙酸诱导的溃疡模型中,芬局酮(150mg/kg)减轻(p<0.001)溃疡性损伤。这些影响与还原型谷胱甘肽(GSH)水平升高有关,超氧化物歧化酶(SOD),白细胞介素(IL)-10和转化生长因子-β(TGF-β)。此外,用(-)-Fenchone(150mg/kg)治疗显着降低(p<0.001)丙二醛(MDA),髓过氧化物酶(MPO),白细胞介素-1β(IL-1β),肿瘤坏死因子-α(TNF-α),核转录因子κB(NF-κB)。一项为期14天的口服毒性研究显示心脏没有改变,肝脏,脾,脾或肾脏重量,在评估的生化和血液学参数中也没有。(-)-Fenchone保护动物免受体重减轻,同时保持饲料和水的摄入量。
结论:(-)-芬酮具有低毒性,预防十二指肠溃疡,并增强胃愈合活动。抗氧化和免疫调节特性似乎涉及其治疗效果。
BACKGROUND: (-)-Fenchone is a naturally occurring
monoterpene found in the essential oils of Foeniculum vulgare Mill., Thuja occidentalis L., and Peumus boldus Molina. Pharmacological studies have reported its antinociceptive, antimicrobial, anti-inflammatory, antidiarrheal, and antioxidant activities.
METHODS: The preventive antiulcer effects of (-)-Fenchone were assessed through oral pretreatment in cysteamine-induced duodenal lesion models. Gastric healing, the underlying mechanisms, and toxicity after repeated doses were evaluated using the acetic acid-induced gastric ulcer rat model with oral treatment administered for 14 days.
RESULTS: In the cysteamine-induced duodenal ulcer model, fenchone (37.5-300 mg/kg) significantly decreased the ulcer area and prevented lesion formation. In the acetic acid-induced ulcer model, fenchone (150 mg/kg) reduced (p < 0.001) ulcerative injury. These effects were associated with increased levels of reduced glutathione (GSH), superoxide dismutase (SOD), interleukin (IL)-10, and transforming growth factor-beta (TGF-β). Furthermore, treatment with (-)-Fenchone (150 mg/kg) significantly reduced (p < 0.001) malondialdehyde (MDA), myeloperoxidase (MPO), interleukin-1 beta (IL-1β), tumor necrosis factor-alpha (TNF-α), and nuclear transcription factor kappa B (NF-κB). A 14-day oral toxicity investigation revealed no alterations in heart, liver, spleen, or kidney weight, nor in the biochemical and hematological parameters assessed. (-)-Fenchone protected animals from body weight loss while maintaining feed and water intake.
CONCLUSIONS: (-)-Fenchone exhibits low toxicity, prevents duodenal ulcers, and enhances gastric healing activities. Antioxidant and immunomodulatory properties appear to be involved in its therapeutic effects.