Abstract：
Aging is one of the risk factors involved in the development of erectile dysfunction (ED). Growing evidence suggests that oxidative stress is the critical mediator of changes in endothelial function and penile vascular tone in the aging process. Thus, reducing reactive oxygen species (ROS) levels may preserve the bioactivity of the penile vasculature. Antioxidant compounds, such as carvacrol, limit the damage caused by ROS and, therefore, benefit the treatment of ED. Thus, this study aims to evaluate the effects of carvacrol on ED using the D-( +)-galactose aging model. The animals were divided into five groups: control, D-( +)-galactose 150 mg/kg, carvacrol 50 mg/kg or 100 mg/kg, and sildenafil 1.5 mg/kg treated daily for 8 weeks. The physiological, functional, and morphological characteristics of aging-associated ED were evaluated after treatment with carvacrol. Carvacrol prevented ED in a D-( +)-galactose-induced aging model by reducing hypercontractility, enhancing endothelial dysfunction in the rat corpus cavernosum, and improving endothelial health of rat cavernous endothelial cells. In addition, carvacrol prevented the destruction of erectile components essential for penile erection and promoted a reduction of penile tissue senescence, probably through mechanisms that involve the harmful modulation of oxidative stress. Carvacrol significantly improved the erectile function of rats in a D-( +)-galactose-induced aging model and has excellent potential as a new therapeutic alternative in treating erectile dysfunction.
摘要：
衰老是勃起功能障碍（ED）发展的危险因素之一。越来越多的证据表明，氧化应激是衰老过程中内皮功能和阴茎血管张力变化的关键介质。因此，降低活性氧（ROS）水平可以保持阴茎脉管系统的生物活性。抗氧化化合物,比如香芹酚,限制ROS造成的损害，因此,有利于ED的治疗。因此，本研究旨在使用D-（）-半乳糖衰老模型评估香芹酚对ED的影响。将动物分为五组：对照组，D-(+)-半乳糖150mg/kg,香芹酚50mg/kg或100mg/kg，和西地那非1.5mg/kg每日治疗8周。生理，功能，用香芹酚治疗后评价衰老相关ED的形态学特征。香芹酚在D-（+）-半乳糖诱导的衰老模型中通过减少过度收缩来预防ED，增强大鼠海绵体的内皮功能障碍，改善大鼠海绵状内皮细胞的内皮健康。此外,香芹酚可防止阴茎勃起所必需的勃起成分的破坏，并促进阴茎组织衰老的减少，可能是通过涉及氧化应激有害调节的机制。香芹酚在D-（）-半乳糖诱导的衰老模型中显着改善了大鼠的勃起功能，并且作为治疗勃起功能障碍的新治疗方法具有出色的潜力。
