Mobile

Mobile
  • 文章类型: Journal Article
    随着伤口评估应用程序在各种应用程序商店中的激增以及人工智能(AI)在医疗保健应用程序中的日益集成,越来越需要一个全面的评估系统。当前的应用程序缺乏足够的基于证据的可靠性,提示有必要进行系统评估。这项研究的目的是评估伤口评估和监测应用程序,确定限制,并概述未来应用开发的机会。在两个主要的应用商店(GooglePlay商店,和AppleAppStore)进行,并由三个独立评估者对选定的应用程序进行评级。总共发现了170个应用程序,根据一组纳入和排除标准选择了10例进行审查.通过修改现有比例,创建伤口评估应用程序的应用程序评级量表,并用于评估选定的10个应用程序。我们的评级量表评估应用程序的功能和软件质量特征。应用商店中的大多数应用,根据我们的评估,不符合伤口监测和评估的总体要求。我们审查的所有应用程序都集中在医生和医生身上。根据我们的评估,应用程序ImitoWound获得了最高的平均得分4.24。但是这个应用程序有7个标准在我们的11个功能标准。最后,我们推荐了未来利用先进技术的机会,特别是那些涉及人工智能的,以增强伤口评估应用程序的功能和功效。这项研究为寻求加强基于伤口评估的应用程序的设计的未来开发人员和研究人员提供了宝贵的资源。包括软件质量和功能的改进。
    With the proliferation of wound assessment apps across various app stores and the increasing integration of artificial intelligence (AI) in healthcare apps, there is a growing need for a comprehensive evaluation system. Current apps lack sufficient evidence-based reliability, prompting the necessity for a systematic assessment. The objectives of this study are to evaluate the wound assessment and monitoring apps, identify limitations, and outline opportunities for future app development. An electronic search across two major app stores (Google Play store, and Apple App Store) was conducted and the selected apps were rated by three independent raters. A total of 170 apps were discovered, and 10 were selected for review based on a set of inclusion and exclusion criteria. By modifying existing scales, an app rating scale for wound assessment apps is created and used to evaluate the selected ten apps. Our rating scale evaluates apps\' functionality and software quality characteristics. Most apps in the app stores, according to our evaluation, do not meet the overall requirements for wound monitoring and assessment. All the apps that we reviewed are focused on practitioners and doctors. According to our evaluation, the app ImitoWound got the highest mean score of 4.24. But this app has 7 criteria among our 11 functionalities criteria. Finally, we have recommended future opportunities to leverage advanced techniques, particularly those involving artificial intelligence, to enhance the functionality and efficacy of wound assessment apps. This research serves as a valuable resource for future developers and researchers seeking to enhance the design of wound assessment-based applications, encompassing improvements in both software quality and functionality.
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  • 文章类型: Journal Article
    背景:2001年9月11日袭击美国后服役的年轻成年退伍军人(即,9/11后)面临更高的行为健康困扰和障碍风险,包括危险饮酒,创伤后应激障碍,和抑郁症。这些退伍军人在行为健康治疗方面经常面临重大障碍,通过简短的基于手机的干预措施可以帮助他们减少饮酒并促进治疗参与。
    目的:经过成功的试点研究,这项随机对照试验(RCT)旨在进一步测试简短(即,单一会话)手机交付的个性化规范反馈干预增强了内容,以促进治疗参与。
    方法:我们将对800名具有潜在危险饮酒且最近未接受任何行为健康问题治疗的9/11后年轻成年退伍军人(年龄18至40岁)进行RCT。参与者将被随机分配到个性化干预或控制条件,并拥有寻求护理的资源。干预中的个性化规范反馈模块侧重于纠正对同伴饮酒的误解规范,并使用经验知情的方法来增加解决饮酒和共同发生的行为健康问题的动机。过去30天饮酒,与酒精有关的后果,和寻求治疗的行为将在基线和干预后3,6,9和12个月进行评估.性,护理障碍,创伤后应激障碍,抑郁症,和酒精使用障碍症状的严重程度将作为结局的潜在调节因素进行探讨。
    结果:我们预计招聘将在6个月内完成,每个注册参与者的数据收集需要12个月。分析将在最终数据收集点后的3个月内开始(即,12个月随访)。
    结论:这项RCT将评估一种新型干预措施的有效性,该措施适用于那些与危险饮酒和可能同时发生的行为健康问题作斗争的非寻求治疗的退伍军人。这种干预措施有可能改善退伍军人的健康状况,并克服治疗的重大障碍。
    背景:ClinicalTrials.govNCT04244461;https://clinicaltrials.gov/study/NCT04244461。
    DERR1-10.2196/59993。
    BACKGROUND: Young adult veterans who served after the September 11 attacks on the United States in 2001 (ie, post-9/11) are at heightened risk for experiencing behavioral health distress and disorders including hazardous drinking, posttraumatic stress disorder, and depression. These veterans often face significant barriers to behavioral health treatment, and reaching them through brief mobile phone-based interventions may help reduce drinking and promote treatment engagement.
    OBJECTIVE: Following a successful pilot study, this randomized controlled trial (RCT) aims to further test the efficacy of a brief (ie, single session) mobile phone-delivered personalized normative feedback intervention enhanced with content to promote treatment engagement.
    METHODS: We will conduct an RCT with 800 post-9/11 young adult veterans (aged 18 to 40 years) with potentially hazardous drinking and who have not recently received treatment for any behavioral health problems. Participants will be randomly assigned to the personalized intervention or a control condition with resources for seeking care. The personalized normative feedback module in the intervention focuses on the correction of misperceived norms of peer alcohol use and uses empirically informed approaches to increase motivation to address alcohol use and co-occurring behavioral health problems. Past 30-day drinking, alcohol-related consequences, and treatment-seeking behaviors will be assessed at baseline and 3, 6, 9, and 12 months post intervention. Sex, barriers to care, posttraumatic stress disorder, depression, and severity of alcohol use disorder symptoms will be explored as potential moderators of outcomes.
    RESULTS: We expect recruitment to be completed within 6 months, with data collection taking 12 months for each enrolled participant. Analyses will begin within 3 months of the final data collection point (ie, 12 months follow-up).
    CONCLUSIONS: This RCT will evaluate the efficacy of a novel intervention for non-treatment-seeking veterans who struggle with hazardous drinking and possible co-occurring behavioral health problems. This intervention has the potential to improve veteran health outcomes and overcome significant barriers to treatment.
    BACKGROUND: ClinicalTrials.gov NCT04244461; https://clinicaltrials.gov/study/NCT04244461.
    UNASSIGNED: DERR1-10.2196/59993.
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  • 文章类型: Journal Article
    背景:脂肪移植物广泛用于塑料中,美学和重建手术。它们不可预测的再吸收是它们的主要缺点。对文献的回顾表明,在脂肪移植应用中,缺乏关于移动和固定区域对脂肪移植存活的影响的研究。
    目的:我们的目的是在新的实验模型中研究脂肪移植物存活与移动和不移动区域的关系。
    方法:将24只雄性Wistar白化病大鼠随机分为两组(n=12)。从大鼠的右腹股沟区收获脂肪移植物。在组1中,将脂肪移植物放置在大鼠头皮区域中形成的皮下袋中。在第2组中,将脂肪移植物放置在大鼠后颈区域形成的小袋中。在6周结束时,评估了脂肪移植物的重量和组织病理学。以盲法方式进行组织病理学检查。
    结果:发现第1组脂肪移植物的重量较高。同时,组织病理学检查显示第1组血管密度较高。其他组织病理学检查无统计学差异。
    结论:移动区域和固定区域可能对移植脂肪移植物的存活有不同的影响。在移动区中的肌肉和皮肤之间的滑动运动对脂肪移植物施加压力。在我们的研究中,显示移动部位对脂肪移植物的血管分布有负面影响。观察到放置在固定区域中的脂肪移植物中的血管密度较高。可以使用我们创建的新实验模型对血管分布增加进行进一步研究。
    方法:本期刊要求作者为每个提交的证据分配一个级别,该级别的证据适用于循证医学排名。这不包括评论文章,书评,和有关基础科学的手稿,动物研究,尸体研究,和实验研究。对于这些循证医学评级的完整描述,请参阅目录或在线作者说明www。springer.com/00266.
    BACKGROUND: Fat grafts are widely used in plastic, aesthetic and reconstructive surgery. Their unpredictable resorption is their main disadvantage. A review of the literature shows that there is a lack of research on the effect of mobile and immobile regions on fat graft survival in fat graft applications.
    OBJECTIVE: Our aim was to investigate the relationship of fat graft survival with mobile and immobile region in a new experimental model.
    METHODS: Twenty-four male Wistar albino rats were randomly divided into two groups (n=12). Fat grafts were harvested from the right inguinal region of the rat. In Group 1, the fat graft was placed in the subcutaneous pouch formed in the scalp region of the rat. In Group 2, fat grafts were placed in the pouch formed in the posterior cervical region of the rat. At the end of 6 weeks, the weights and histopathology of the fat grafts were evaluated. Histopathological examinations were performed in a blinded fashion.
    RESULTS: The weights of the fat grafts were found to be higher in Group 1. At the same time, histopathological examinations showed that vascular density was higher in Group 1. There was no statistically significant difference in other histopathological examinations.
    CONCLUSIONS: The mobile and immobile areas may have different effects on the survival of transplanted fat grafts. Sliding movement between muscle and skin in the mobile zone puts stress on the fat graft. In our study, the mobile site was shown to have a negative effect on the vascularity of the fat graft. It was observed that the vascular density was higher in the fat graft placed in the immobilised area. Further studies on the increase in vascularity can be carried out using the new experimental model we have created.
    METHODS: This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
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  • 文章类型: Journal Article
    人类活动识别(HAR)在医疗保健和老年人保健(远程康复,远程监控),安全,人体工程学,娱乐(健身,体育推广,人机交互,视频游戏),和智能环境。本文解决了在运动训练中进行的12种练习的实时识别和重复计数问题。我们的方法基于深层神经网络模型,该模型由放置在胸部的9轴运动传感器(IMU)的信号提供。该模型可以在移动平台上运行(iOS,Android)。我们讨论了系统的设计要求及其对数据收集协议的影响。我们提出了基于预训练对比学习的编码器的体系结构。与端到端训练相比,所提出的方法在准确性方面显著提高了开发模型的质量(F1分数,MAPE)和背景活动期间的鲁棒性(假阳性率)。我们将AIDLAB-HAR数据集公开提供,以鼓励进一步的研究。
    Human Activity Recognition (HAR) plays an important role in the automation of various tasks related to activity tracking in such areas as healthcare and eldercare (telerehabilitation, telemonitoring), security, ergonomics, entertainment (fitness, sports promotion, human-computer interaction, video games), and intelligent environments. This paper tackles the problem of real-time recognition and repetition counting of 12 types of exercises performed during athletic workouts. Our approach is based on the deep neural network model fed by the signal from a 9-axis motion sensor (IMU) placed on the chest. The model can be run on mobile platforms (iOS, Android). We discuss design requirements for the system and their impact on data collection protocols. We present architecture based on an encoder pretrained with contrastive learning. Compared to end-to-end training, the presented approach significantly improves the developed model\'s quality in terms of accuracy (F1 score, MAPE) and robustness (false-positive rate) during background activity. We make the AIDLAB-HAR dataset publicly available to encourage further research.
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  • 文章类型: Journal Article
    背景:在过去的几年中,医生和面向患者的护理人员越来越多地使用移动健康(mHealth)技术,在COVID-19大流行期间加速。然而,围绕收养的障碍和反馈仍然相对缺乏研究,并且在整个卫生系统中各不相同,特别是在农村地区。
    目的:本研究旨在确定供应商的采用,态度,以及大型移动健康的障碍,多站点,美国农村医疗系统。我们调查了(1)提供商为自己的利益使用的mHealth应用程序和(2)提供商与患者一起使用的mHealth应用程序。
    方法:我们调查了马什菲尔德诊所健康系统内的所有看病者,16项,基于网络的调查评估对mHealth的态度,采用这些技术,以及提供者面临的感知障碍,他们的同龄人,和机构。调查结果通过描述性统计进行总结,使用对数二项回归和伴随的成对分析,使用Kruskal-Wallis和Jonckheere-Terpstra检验进行显著性检验,分别。受访者按报告的临床角色和专业进行分组。
    结果:我们收到了38%(n/N=916/2410)的响应率,60.7%(n=556)的那些足够完整的分析。大约54.1%(n=301)的受访者表示使用mHealth,主要围绕决策和补充信息,根据提供者角色和多年的经验,使用不同。自我报告使用mHealth的障碍包括缺乏知识和时间来研究mHealth技术。提供商还报告了对患者互联网访问以及mHealth应用程序充分使用mHealth技术的复杂性的担忧。供应商认为卫生系统的障碍主要是隐私,保密性,和法律审查问题。
    结论:这些发现与其他卫生系统的类似研究相呼应,周围的提供者缺乏时间和对患者数据隐私和机密性的担忧。供应商强调了对这些技术对患者的复杂性的担忧,以及对患者在提供护理时充分利用mHealth的互联网访问的担忧。
    BACKGROUND: Physicians and patient-facing caregivers have increasingly used mobile health (mHealth) technologies in the past several years, accelerating during the COVID-19 pandemic. However, barriers and feedback surrounding adoption remain relatively understudied and varied across health systems, particularly in rural areas.
    OBJECTIVE: This study aims to identify provider adoption, attitudes, and barriers toward mHealth in a large, multisite, rural US health care system. We investigated (1) mHealth apps that providers use for their own benefit and (2) mHealth apps that a provider uses in conjunction with a patient.
    METHODS: We surveyed all patient-seeing providers within the Marshfield Clinic Health System with a brief, 16-item, web-based survey assessing attitudes toward mHealth, adoption of these technologies, and perceived barriers faced by providers, their peers, and the institution. Survey results were summarized via descriptive statistics, with log-binomial regression and accompanying pairwise analyses, using Kruskal-Wallis and Jonckheere-Terpstra tests for significance, respectively. Respondents were grouped by reported clinical role and specialty.
    RESULTS: We received a 38% (n/N=916/2410) response rate, with 60.7% (n=556) of those sufficiently complete for analyses. Roughly 54.1% (n=301) of respondents reported mHealth use, primarily around decision-making and supplemental information, with use differing based on provider role and years of experience. Self-reported barriers to using mHealth included a lack of knowledge and time to study mHealth technologies. Providers also reported concerns about patients\' internet access and the complexity of mHealth apps to adequately use mHealth technologies. Providers believed the health system\'s barriers were largely privacy, confidentiality, and legal review concerns.
    CONCLUSIONS: These findings echo similar studies in other health systems, surrounding providers\' lack of time and concerns over privacy and confidentiality of patient data. Providers emphasized concerns over the complexity of these technologies for their patients and concerns over patients\' internet access to fully use mHealth in their delivery of care.
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  • 文章类型: Journal Article
    皮肤镜检查是一种在高倍镜下检查皮肤病变的非侵入性方法,逐渐取代侵入性活检的需要。需要培训以获得临床能力。游戏化采用类似游戏的元素来增强教育参与度,是提供医学教育的一种吸引人的手段。我们试图使用游戏化和基于移动的平台向医生提供皮肤镜检查教育。
    我们开发了SKIN@GoPRIME,交互式智能手机平台。30名医生参与者被随机分配观看在线皮肤镜检查讲座或使用SKIN@GoPRIME。28名参与者完成了学习前和学习后的测验,并提供了有关SKIN@GoPRIME的反馈。
    SKIN@GoPRIME的用户表现出显着的1.71分平均得分提高(P=.0018)。观看在线皮肤镜检查讲座的组平均得分提高了2.36分(P=.00021)。家庭医学和内科医师均显示出1.29(P=0.049)和2.14(P=0.023)的显着平均得分增加,分别,使用皮肤@GoPRIME后。根据反馈,83%的人认为SKIN@GoPRIME可用于获得其工作范围所需的应用能力。
    皮肤@GoPRIME,一种新颖的学习工具,通过游戏化有效地提供皮肤镜检查教育,虽然它没有被证明比讲座更有效。需要更大规模的研究来进一步验证游戏化学习技术在皮肤镜教育中的有效性。未来的研究应该包括优化SKIN@GoPRIME,以更有效地提供皮肤镜检查教育。
    UNASSIGNED: Dermatoscopy is a noninvasive method of examining skin lesions under high magnification, gradually replacing the need for invasive biopsies. Training is required to gain clinical competency. Gamification employs game-like elements to enhance education engagement and is an engaging means of delivering medical education. We sought to use gamification and a mobile-based platform to deliver dermatoscopy education to physicians.
    UNASSIGNED: We developed SKIN@GoPRIME, an interactive smartphone platform. Thirty physician participants were randomly assigned to watch an online dermatoscopy lecture or to use SKIN@GoPRIME. Twenty-eight participants completed prelearning and postlearning quizzes and provided feedback on SKIN@GoPRIME.
    UNASSIGNED: Users of SKIN@GoPRIME demonstrated a significant 1.71-point mean score improvement (P = .0018). The group that watched the online dermatoscopy lecture had a higher 2.36-point mean score improvement (P = .00021). Both family medicine and internal medicine physicians demonstrated a significant mean score increase of 1.29 (P = .049) and 2.14 (P = .023), respectively, after using SKIN@GoPRIME. Based on feedback, 83% believed that SKIN@GoPRIME can be used to acquire the applied competencies required for their job scope.
    UNASSIGNED: SKIN@GoPRIME, a novel learning tool via gamification effectively delivers dermatoscopy education, although it is not shown to be more effective than lectures. Larger studies are required to further validate the effectiveness of gamified learning techniques in dermatoscopy education. Future studies should involve the optimization of SKIN@GoPRIME to more effectively deliver dermatoscopy education.
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  • 文章类型: Journal Article
    城市动态和人为干预导致噪音污染水平上升,对全球医疗保健有相关影响。为减少交通噪音污染而创建的结构,工业,或其他来源被称为噪音,声音,或声屏障。研究论文提出了一种独特的隔音屏障设计和开发,该隔音屏障具有新的声学面板和植物覆盖物的复合混合物,可增强噪音衰减和美观性。屏障提供了围绕垂直轴的对称设计,因此,确保了屏障的两面的利用。此外,该屏障拥有多个插槽,以容纳基于不同噪声频率和环境条件的多材料吸音板。屏障在45°处集成了可移动的噪声帽,90°,180°,和270°角,以进一步衰减和转移噪声。土壤箱内的滴灌系统可确保最佳的植物生长和屏障稳定性。实验研究展示了屏障的性能及其在各种噪声场景中的有效性。这种创新的发展提供了一个全面的解决方案,通过紧凑的噪音缓解,可定制和可持续的绿色噪声屏障。
    Urban dynamics and anthropogenic interventions led to an increase in noise pollution levels, with relevant implications for worldwide healthcare. Structures created to lessen noise pollution from traffic, industry, or other sources are known as noise, sound, or acoustic barriers. The research paper presents a unique design and development of noise barrier with newly composite mix of acoustic panels and vegetative cover augmenting noise attenuation and aesthetics. The barrier provides a symmetrical design around the vertical axis, hence assures utilization of both faces of the barrier. Additionally, the barrier hosts multiple slots to accommodate multi-material acoustic panels based on diverse noise frequencies and environmental conditions. The barrier integrates movable noise caps at 45°, 90°, 180°, and 270° angles for further attenuation and diversion of noise. A drip irrigation system within the soil box ensures optimal plant growth and stability to barrier. Experimental studies showcase the barrier\'s performance and its effectiveness in diverse noise scenarios. This innovative development provides a comprehensive solution towards noise mitigation through compact, customizable and sustainable green noise barrier.
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  • 文章类型: Journal Article
    目标:随着社会技术的不断进步,重要的是解决这一进步如何影响和加强患者护理。这篇综述的目的是确定目前可用于患有血液系统恶性肿瘤的成人和儿科患者以及那些存活的以患者为中心的技术。鉴于恶性血液病患者通常必须坚持严格的药物治疗方案,与许多不同的提供者协调护理,管理与治疗相关的症状,并管理与生存相关的后期影响,他们将从旨在减轻这些负担的以患者为中心的技术中受益匪浅。
    结果:这篇综述发现了针对该患者人群的各种可用的数字干预措施,并重点介绍了市售智能手机应用的概述,患者门户,和远程监控技术。总之,许多数字干预措施用于肿瘤患者的医疗护理。这些干预措施的结合可以提供更个性化的医疗服务,更好地组织照顾者在家里的治疗计划,和容易传递准确的医疗信息。
    OBJECTIVE: As society continues to advance in technology, it is important to address how this advancement can impact and enhance patient care. The purpose of this review is to identify patient-centered technology currently available for adult and pediatric patients with and those having survived hematologic malignancies. Given that patients with hematologic malignancies often have to adhere to strenuous medication regimens, coordinate care with many different providers, manage symptoms associated with treatment, and manage late effects associated with survivorship, they would benefit greatly from patient-centered technology aimed at decreasing these burdens.
    RESULTS: This review found various available digital interventions for this patient population and focuses on an overview of commercially available smartphone applications, patient portals, and technology for remote monitoring. In summary, many digital interventions exist for use in the medical care of oncology patients. The incorporation of these interventions can allow for more personalized medical care, better organization of treatment plans by caregivers at home, and easy delivery of accurate medical information.
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  • 文章类型: Journal Article
    持久性,移动和有毒(PMT),或非常持久和流动性(vPvM)物质是一类广泛的化学物质,难以降解,容易运输,并可能对人类和环境有害。由于他们的持久性和机动性,这些物质一旦排放,通常在环境中广泛存在,特别是在水资源方面,在水处理过程中造成越来越多的挑战。一些PMT/vPvM物质,如GenX和全氟丁烷磺酸已被确定为非常高关注的物质(SVHC)根据欧洲注册,评价,化学品授权和限制(REACH)法规。由于数百至数千种潜在的PMT/vPvM物质尚待评估和管理,有效和高效的方法,避免个案评估和防止令人遗憾的替代是必要的,以实现欧盟的零污染目标,到2050年无毒环境。
    物质分组帮助了一些高度危险化学品的全球监管,例如,《蒙特利尔议定书》和《斯德哥尔摩公约》。本文探讨了分组策略在识别、评估和管理PMT/vPvM物质。目的是促进早期识别可能符合PMT/vPvM标准的鲜为人知或新物质,提示额外的测试,避免令人遗憾的使用或替换,并融入现有的风险管理策略。因此,本文概述了PMT/vPvM物质,并回顾了PMT/vPvM标准的定义以及各种可用的PMT/vPvM物质列表。它涵盖了当前的群体定义,比较了使用物质分组进行危险评估和监管,并讨论了分组物质进行调控的利弊。然后,本文探讨了PMT/vPvM物质的分组策略,包括读取,结构相似性和通常保留的部分,以及这些策略使用化学信息学预测P的潜在应用,所选示例的M和T属性。
    有效的物质分组可以加速PMT/vPvM物质的评估和管理,特别是对于缺乏信息的物质。需要在阅读方法和化学信息学工具方面取得进展,以支持高效和有效的化学品管理,防止危险化学品广泛进入全球市场,并有利于更安全和更可持续的替代品。
    UNASSIGNED: Persistent, mobile and toxic (PMT), or very persistent and very mobile (vPvM) substances are a wide class of chemicals that are recalcitrant to degradation, easily transported, and potentially harmful to humans and the environment. Due to their persistence and mobility, these substances are often widespread in the environment once emitted, particularly in water resources, causing increased challenges during water treatment processes. Some PMT/vPvM substances such as GenX and perfluorobutane sulfonic acid have been identified as substances of very high concern (SVHCs) under the European Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) regulation. With hundreds to thousands of potential PMT/vPvM substances yet to be assessed and managed, effective and efficient approaches that avoid a case-by-case assessment and prevent regrettable substitution are necessary to achieve the European Union\'s zero-pollution goal for a non-toxic environment by 2050.
    UNASSIGNED: Substance grouping has helped global regulation of some highly hazardous chemicals, e.g., through the Montreal Protocol and the Stockholm Convention. This article explores the potential of grouping strategies for identifying, assessing and managing PMT/vPvM substances. The aim is to facilitate early identification of lesser-known or new substances that potentially meet PMT/vPvM criteria, prompt additional testing, avoid regrettable use or substitution, and integrate into existing risk management strategies. Thus, this article provides an overview of PMT/vPvM substances and reviews the definition of PMT/vPvM criteria and various lists of PMT/vPvM substances available. It covers the current definition of groups, compares the use of substance grouping for hazard assessment and regulation, and discusses the advantages and disadvantages of grouping substances for regulation. The article then explores strategies for grouping PMT/vPvM substances, including read-across, structural similarity and commonly retained moieties, as well as the potential application of these strategies using cheminformatics to predict P, M and T properties for selected examples.
    UNASSIGNED: Effective substance grouping can accelerate the assessment and management of PMT/vPvM substances, especially for substances that lack information. Advances to read-across methods and cheminformatics tools are needed to support efficient and effective chemical management, preventing broad entry of hazardous chemicals into the global market and favouring safer and more sustainable alternatives.
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  • 文章类型: Journal Article
    背景:紫外线(UV)暴露行为可以直接影响个人患皮肤癌的风险,在童年和青春期形成了许多习惯。我们探索了光老化智能手机应用程序的实用性,以激励年轻人改善阳光安全实践。
    方法:参与者完成了一项干预前调查,以收集基线的阳光安全感知和行为。然后,参与者使用光老化移动应用程序来查看随着时间的推移,慢性紫外线暴露对参与者的自容图像的预计影响,随后进行干预后调查,以评估从事未来阳光安全措施的动机。
    结果:研究样本包括87名参与者(中位数[四分位数(IQR)]年龄,14[11-16]年)。大多数参与者是白人(50.6%),报告的皮肤类型有点烧伤,容易晒黑(42.5%)。参与者的干预前阳光照射行为显示,有33人(37.9%)在晴天主要或始终使用防晒霜,48人(55.2%)在过去一年中至少经历过一次晒伤,26人(30.6%)在过去一年中至少进行过一次户外日光浴,零(0%)使用室内晒黑床。非肤色(18[41.9%],p=.02)及更老(24[41.4%],p=.007)参与者更经常同意他们晒黑后感觉更好。大多数参与者同意干预措施增加了他们练习防晒行为的动机(穿防晒霜,74[85.1%];戴帽子,64[74.4%];避免室内晒黑,73[83.9%];避免户外晒黑,68[79%])。
    结论:这项横断面研究的结果表明,光老化智能手机应用程序可以作为一种有用的工具来促进年轻时的阳光安全行为。
    BACKGROUND: Ultraviolet (UV)-exposure behaviors can directly impact an individual\'s skin cancer risk, with many habits formed during childhood and adolescence. We explored the utility of a photoaging smartphone application to motivate youth to improve sun safety practices.
    METHODS: Participants completed a preintervention survey to gather baseline sun safety perceptions and behaviors. Participants then used a photoaging mobile application to view the projected effects of chronic UV exposure on participants\' self-face image over time, followed by a postintervention survey to assess motivation to engage in future sun safety practices.
    RESULTS: The study sample included 87 participants (median [interquartile (IQR)] age, 14 [11-16] years). Most participants were White (50.6%) and reported skin type that burns a little and tans easily (42.5%). Preintervention sun exposure behaviors among participants revealed that 33 (37.9%) mostly or always used sunscreen on a sunny day, 48 (55.2%) experienced at least one sunburn over the past year, 26 (30.6%) engaged in outdoor sunbathing at least once during the past year, and zero (0%) used indoor tanning beds. Non-skin of color (18 [41.9%], p = .02) and older (24 [41.4%], p = .007) participants more often agreed they felt better with a tan. Most participants agreed the intervention increased their motivation to practice sun-protective behaviors (wear sunscreen, 74 [85.1%]; wear hats, 64 [74.4%]; avoid indoor tanning, 73 [83.9%]; avoid outdoor tanning, 68 [79%]).
    CONCLUSIONS: The findings of this cross-sectional study suggest that a photoaging smartphone application may serve as a useful tool to promote sun safety behaviors from a young age.
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