背景:脂肪移植物广泛用于塑料中,美学和重建手术。它们不可预测的再吸收是它们的主要缺点。对文献的回顾表明,在脂肪移植应用中,缺乏关于移动和固定区域对脂肪移植存活的影响的研究。
目的:我们的目的是在新的实验模型中研究脂肪移植物存活与移动和不移动区域的关系。
方法:将24只雄性Wistar白化病大鼠随机分为两组(n=12)。从大鼠的右腹股沟区收获脂肪移植物。在组1中,将脂肪移植物放置在大鼠头皮区域中形成的皮下袋中。在第2组中,将脂肪移植物放置在大鼠后颈区域形成的小袋中。在6周结束时,评估了脂肪移植物的重量和组织病理学。以盲法方式进行组织病理学检查。
结果:发现第1组脂肪移植物的重量较高。同时,组织病理学检查显示第1组血管密度较高。其他组织病理学检查无统计学差异。
结论:移动区域和固定区域可能对移植脂肪移植物的存活有不同的影响。在移动区中的肌肉和皮肤之间的滑动运动对脂肪移植物施加压力。在我们的研究中,显示移动部位对脂肪移植物的血管分布有负面影响。观察到放置在固定区域中的脂肪移植物中的血管密度较高。可以使用我们创建的新实验模型对血管分布增加进行进一步研究。
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BACKGROUND: Fat grafts are widely used in plastic, aesthetic and reconstructive surgery. Their unpredictable resorption is their main disadvantage. A review of the literature shows that there is a lack of research on the effect of
mobile and immobile regions on fat graft survival in fat graft applications.
OBJECTIVE: Our aim was to investigate the relationship of fat graft survival with
mobile and immobile region in a new experimental model.
METHODS: Twenty-four male Wistar albino rats were randomly divided into two groups (n=12). Fat grafts were harvested from the right inguinal region of the rat. In Group 1, the fat graft was placed in the subcutaneous pouch formed in the scalp region of the rat. In Group 2, fat grafts were placed in the pouch formed in the posterior cervical region of the rat. At the end of 6 weeks, the weights and histopathology of the fat grafts were evaluated. Histopathological examinations were performed in a blinded fashion.
RESULTS: The weights of the fat grafts were found to be higher in Group 1. At the same time, histopathological examinations showed that vascular density was higher in Group 1. There was no statistically significant difference in other histopathological examinations.
CONCLUSIONS: The
mobile and immobile areas may have different effects on the survival of transplanted fat grafts. Sliding movement between muscle and skin in the
mobile zone puts stress on the fat graft. In our study, the
mobile site was shown to have a negative effect on the vascularity of the fat graft. It was observed that the vascular density was higher in the fat graft placed in the immobilised area. Further studies on the increase in vascularity can be carried out using the new experimental model we have created.
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