PDF(Pubmed)
Abstract：
UNASSIGNED: Persistent, mobile and toxic (PMT), or very persistent and very mobile (vPvM) substances are a wide class of chemicals that are recalcitrant to degradation, easily transported, and potentially harmful to humans and the environment. Due to their persistence and mobility, these substances are often widespread in the environment once emitted, particularly in water resources, causing increased challenges during water treatment processes. Some PMT/vPvM substances such as GenX and perfluorobutane sulfonic acid have been identified as substances of very high concern (SVHCs) under the European Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) regulation. With hundreds to thousands of potential PMT/vPvM substances yet to be assessed and managed, effective and efficient approaches that avoid a case-by-case assessment and prevent regrettable substitution are necessary to achieve the European Union\'s zero-pollution goal for a non-toxic environment by 2050.
UNASSIGNED: Substance grouping has helped global regulation of some highly hazardous chemicals, e.g., through the Montreal Protocol and the Stockholm Convention. This article explores the potential of grouping strategies for identifying, assessing and managing PMT/vPvM substances. The aim is to facilitate early identification of lesser-known or new substances that potentially meet PMT/vPvM criteria, prompt additional testing, avoid regrettable use or substitution, and integrate into existing risk management strategies. Thus, this article provides an overview of PMT/vPvM substances and reviews the definition of PMT/vPvM criteria and various lists of PMT/vPvM substances available. It covers the current definition of groups, compares the use of substance grouping for hazard assessment and regulation, and discusses the advantages and disadvantages of grouping substances for regulation. The article then explores strategies for grouping PMT/vPvM substances, including read-across, structural similarity and commonly retained moieties, as well as the potential application of these strategies using cheminformatics to predict P, M and T properties for selected examples.
UNASSIGNED: Effective substance grouping can accelerate the assessment and management of PMT/vPvM substances, especially for substances that lack information. Advances to read-across methods and cheminformatics tools are needed to support efficient and effective chemical management, preventing broad entry of hazardous chemicals into the global market and favouring safer and more sustainable alternatives.
UNASSIGNED: Substance grouping has helped global regulation of some highly hazardous chemicals, e.g., through the Montreal Protocol and the Stockholm Convention. This article explores the potential of grouping strategies for identifying, assessing and managing PMT/vPvM substances. The aim is to facilitate early identification of lesser-known or new substances that potentially meet PMT/vPvM criteria, prompt additional testing, avoid regrettable use or substitution, and integrate into existing risk management strategies. Thus, this article provides an overview of PMT/vPvM substances and reviews the definition of PMT/vPvM criteria and various lists of PMT/vPvM substances available. It covers the current definition of groups, compares the use of substance grouping for hazard assessment and regulation, and discusses the advantages and disadvantages of grouping substances for regulation. The article then explores strategies for grouping PMT/vPvM substances, including read-across, structural similarity and commonly retained moieties, as well as the potential application of these strategies using cheminformatics to predict P, M and T properties for selected examples.
UNASSIGNED: Effective substance grouping can accelerate the assessment and management of PMT/vPvM substances, especially for substances that lack information. Advances to read-across methods and cheminformatics tools are needed to support efficient and effective chemical management, preventing broad entry of hazardous chemicals into the global market and favouring safer and more sustainable alternatives.
摘要：
■持久性，移动和有毒（PMT），或非常持久和流动性（vPvM）物质是一类广泛的化学物质，难以降解，容易运输,并可能对人类和环境有害。由于他们的持久性和机动性，这些物质一旦排放，通常在环境中广泛存在，特别是在水资源方面，在水处理过程中造成越来越多的挑战。一些PMT/vPvM物质，如GenX和全氟丁烷磺酸已被确定为非常高关注的物质（SVHC）根据欧洲注册，评价,化学品授权和限制（REACH）法规。由于数百至数千种潜在的PMT/vPvM物质尚待评估和管理，有效和高效的方法，避免个案评估和防止令人遗憾的替代是必要的，以实现欧盟的零污染目标，到2050年无毒环境。
■物质分组帮助了一些高度危险化学品的全球监管，例如，《蒙特利尔议定书》和《斯德哥尔摩公约》。本文探讨了分组策略在识别、评估和管理PMT/vPvM物质。目的是促进早期识别可能符合PMT/vPvM标准的鲜为人知或新物质，提示额外的测试，避免令人遗憾的使用或替换，并融入现有的风险管理策略。因此，本文概述了PMT/vPvM物质，并回顾了PMT/vPvM标准的定义以及各种可用的PMT/vPvM物质列表。它涵盖了当前的群体定义，比较了使用物质分组进行危险评估和监管，并讨论了分组物质进行调控的利弊。然后，本文探讨了PMT/vPvM物质的分组策略，包括读取，结构相似性和通常保留的部分，以及这些策略使用化学信息学预测P的潜在应用，所选示例的M和T属性。
■有效的物质分组可以加速PMT/vPvM物质的评估和管理，特别是对于缺乏信息的物质。需要在阅读方法和化学信息学工具方面取得进展，以支持高效和有效的化学品管理，防止危险化学品广泛进入全球市场，并有利于更安全和更可持续的替代品。
■物质分组帮助了一些高度危险化学品的全球监管，例如，《蒙特利尔议定书》和《斯德哥尔摩公约》。本文探讨了分组策略在识别、评估和管理PMT/vPvM物质。目的是促进早期识别可能符合PMT/vPvM标准的鲜为人知或新物质，提示额外的测试，避免令人遗憾的使用或替换，并融入现有的风险管理策略。因此，本文概述了PMT/vPvM物质，并回顾了PMT/vPvM标准的定义以及各种可用的PMT/vPvM物质列表。它涵盖了当前的群体定义，比较了使用物质分组进行危险评估和监管，并讨论了分组物质进行调控的利弊。然后，本文探讨了PMT/vPvM物质的分组策略，包括读取，结构相似性和通常保留的部分，以及这些策略使用化学信息学预测P的潜在应用，所选示例的M和T属性。
■有效的物质分组可以加速PMT/vPvM物质的评估和管理，特别是对于缺乏信息的物质。需要在阅读方法和化学信息学工具方面取得进展，以支持高效和有效的化学品管理，防止危险化学品广泛进入全球市场，并有利于更安全和更可持续的替代品。
