目的:初潮年龄与可育性有关吗?
结论:初潮早期(<11岁)和晚期(>15岁)均与可育性降低有关。
背景:先前关于初潮年龄和可育性的研究尚无定论。初潮早或晚的女性患妇科和自身免疫性疾病的风险增加,这可能会影响她们的受孕能力。
方法:我们进行了一项回顾性队列研究,包括67613名孕妇,参加挪威母亲,1999年至2008年的父亲和儿童队列研究,包括月经初潮年龄和怀孕时间的自我报告信息。我们包括自然或辅助生殖技术帮助下的计划怀孕。
方法:我们以95%CIs计算了按月经初潮年龄分类的特定周期受孕概率。根据参与者的孕前体重指数调整FR,完成或持续教育的最高水平,以及开始尝试怀孕的年龄。
结果:我们观察到,在月经初潮早或晚的女性中,在任何给定的月经周期中,受孕的可能性降低了7%。在月经初潮>15岁的女性中,调整后的FR为0.93(95%CI:0.90-0.97),在月经初潮<11岁的女性中,调整后的FR为0.93(95%CI:0.89-0.99),与初潮在12至14岁之间的女性相比。
结论:研究人群包括妊娠中期的妇女,不包括那些持续性不孕症。回忆初潮时的年龄和怀孕时间可能不准确。
结论:初潮早期(<11岁)和晚期(>15岁)均与可育性降低有关。初潮早或初潮晚的妇女可能会得到相应的建议。
背景:这项研究由挪威公共卫生研究所资助,奥斯陆,挪威,Telemark医院信托基金,Porsgrunn,挪威,并通过其卓越中心资助计划(项目编号262700)和挪威研究理事会(项目编号:320656)。该项目由欧洲联盟(ERC,生物,101071773).然而,所表达的观点和意见仅是作者的观点和意见,不一定反映欧盟或欧洲研究理事会的观点和意见。欧洲联盟和授予机构都不能对此负责。M.C.M.根据欧盟的“地平线2020”研究和创新计划(赠款协议编号:947684)。作者报告没有相互竞争的利益。
背景:不适用。
OBJECTIVE: Is age at menarche associated with fecundability?
CONCLUSIONS: Both early (<11 years) and late (>15 years) menarche is associated with decreased fecundability.
BACKGROUND: Previous studies on age at menarche and fecundability have been inconclusive. Women with early or late menarche are at increased risks of gynaecological and autoimmune diseases that may affect their ability to conceive.
METHODS: We conducted a retrospective cohort study including 67 613 pregnant women, participating in the Norwegian Mother, Father and Child Cohort Study between 1999 and 2008, with self-reported information on age at menarche and time to pregnancy. We included planned pregnancies that were conceived either naturally or with the help of assisted reproductive technologies.
METHODS: We calculated fecundability ratios (FRs) with 95% CIs representing the cycle-specific probability of conception by categories of age at menarche. FRs were adjusted for participants\' pre-pregnancy body mass index, highest completed or ongoing education level, and age at initiation of trying to conceive.
RESULTS: We observed a 7% lower probability of conceiving during any given menstrual cycle up to 12 cycles in women with early or late menarche. Among women with menarche >15 years, the adjusted FR was 0.93 (95% CI: 0.90-0.97), and among women with menarche <11 years, the adjusted FR was 0.93 (95% CI: 0.89-0.99), when compared to women with menarche between 12 and 14 years.
CONCLUSIONS: The study-population consisted of women pregnant in their second trimester, excluding those with persistent infertility. Recall of age at menarche and time to pregnancy may be inaccurate.
CONCLUSIONS: Both early (<11 years) and late (>15 years) menarche was associated with decreased fecundability. Women experiencing early menarche or late menarche may be counselled accordingly.
BACKGROUND: This study was funded by the Norwegian Institute of Public Health, Oslo, Norway, and by Telemark Hospital Trust, Porsgrunn, Norway and was partly supported by the Research Council of Norway through its centres of excellence funding scheme (project number 262700) and the Research Council of Norway (project no. 320656). The project was co-funded by the European Union (ERC, BIOSFER, 101071773). Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Research Council. Neither the European Union nor the granting authority can be held responsible for them. M.C.M. has received funding from the European Research Council (ERC) under the European Union\'s Horizon 2020 research and innovation program (grant agreement no. 947684). The authors report no competing interests.
BACKGROUND: N/A.