PDF(Pubmed)
Abstract：
Psychological stress during pregnancy is known to have a range of long-lasting negative consequences on the development and health of offspring. Here, we tested whether a measure of prenatal early-life stress was associated with a biomarker of physiological development at birth, namely epigenetic gestational age, using foetal cord-blood DNA-methylation data. Longitudinal cohorts from the Netherlands (Generation R Study [Generation R], n = 1,396), the UK (British Avon Longitudinal Study of Parents and Children [ALSPAC], n = 642), and Norway (Mother, Father and Child Cohort Study [MoBa], n1 = 1,212 and n2 = 678) provided data on prenatal maternal stress and genome-wide DNA methylation from cord blood and were meta-analysed (pooled n = 3,928). Measures of epigenetic age acceleration were calculated using three different gestational epigenetic clocks: \"Bohlin\", \"EPIC overlap\" and \"Knight\". Prenatal stress exposure, examined as an overall cumulative score, was not significantly associated with epigenetically-estimated gestational age acceleration or deceleration in any of the clocks, based on the results of the pooled meta-analysis or those of the individual cohorts. No significant associations were identified with specific domains of prenatal stress exposure, including negative life events, contextual (socio-economic) stressors, parental risks (e.g., maternal psychopathology) and interpersonal risks (e.g., family conflict). Further, no significant associations were identified when analyses were stratified by sex. Overall, we find little support that prenatal psychosocial stress is associated with variation in epigenetic age at birth within the general paediatric population.
摘要：
众所周知，怀孕期间的心理压力会对后代的发育和健康产生一系列持久的负面影响。这里,我们测试了产前早期生活压力的测量是否与出生时生理发育的生物标志物相关，即表观遗传胎龄，使用胎儿脐带血DNA甲基化数据。来自荷兰的纵向队列(R代研究[R代]，n=1,396)，英国(英国雅芳父母和子女纵向研究[ALSPAC]，n=642)，挪威（母亲，父亲和孩子队列研究[MoBa]，n1=1,212和n2=678）提供了有关产前母体压力和脐带血全基因组DNA甲基化的数据，并进行了荟萃分析（合并n=3,928）。使用三个不同的妊娠表观遗传时钟计算表观遗传年龄加速的度量：“Bohlin”，“EPIC重叠”和“骑士”。产前压力暴露,作为总体累积分数进行检查，在任何时钟中与表观遗传学估计的胎龄加速或减速没有显着相关，基于汇总荟萃分析的结果或单个队列的结果.没有发现与产前应激暴露的特定领域有显著关联，包括负面生活事件，背景(社会经济)压力源，父母的风险(例如，产妇精神病理学)和人际关系风险(例如，家庭冲突)。Further,当分析按性别分层时,未发现显著关联.总的来说,我们发现,在一般儿科人群中,产前心理社会应激与出生时表观遗传年龄的变化相关的支持很少.
