背景:据报道,产前暴露于米索前列醇(PEM)与莫比乌斯综合征(MS)或序列之间的联系日益密切。我们的目标是描述与MS相关的颅面临床表现并确定PEM的频率。比较暴露和未暴露的情况。
方法:描述性,140例MS患者的横断面研究临床评估,以及对居住在哥伦比亚39个城市或地区的母亲的140次采访,在2008年4月至2018年5月期间进行。此外,回顾了每个病例的既往临床病史.
结果:MS患者的平均年龄为8.4岁(29天至48岁)。他们都表现出面神经受累和外展,112例(80.8%)伴双侧面瘫。98.5%的人出现颅面疾病,暴露和未暴露米索前列醇的患者之间没有显着差异。47%的患者(64例)进行PEM,其中98.4%的人打算堕胎。
结论:PEM可以通过增加妊娠期间出血的频率来影响MS新病例的出现,不会增加相关颅面畸形的数量。我们介绍了文献中关于MS和颅面发现的最大系列,以及对其理解有意义的参考。
方法:3b。
BACKGROUND: A growing link between prenatal exposure to misoprostol (PEM) and Moebius syndrome (MS) or sequence has been reported. Our objectives were to describe the craniofacial clinical manifestations associated with MS and to determine the frequency of PEM, comparing cases of exposure and nonexposure.
METHODS: A descriptive, cross-sectional study of 140 patients with MS. Clinical evaluations, as well as 140 interviews with mothers residing in 39 cities or districts of Colombia, were carried out between April 2008 and May 2018. Additionally, previous clinical history of each case was reviewed.
RESULTS: The average age of the patients with MS was 8.4 years (29 days to 48 years). All of them presented facial nerve involvement and abducens, 112 (80.8%) with bilateral facial paralysis. 98.5% presented craniofacial disorders, and there were no significant differences between those exposed and not exposed to misoprostol. Forty-seven percentage of patients (64 cases) presented PEM, in 98.4% of which abortion had been intended.
CONCLUSIONS: PEM could have an influence in the appearance of new cases of MS by increasing the frequency of bleeding during gestation, without increasing the number of associated craniofacial malformations. We present the biggest series on MS and craniofacial findings in the literature, along with a meaningful reference for its understanding.
METHODS: 3b.