%0 Journal Article
%T Clinical findings in children with congenital anomalies and misoprostol intrauterine exposure: a study of 38 cases.
%A Vendramini-Pittoli S
%A Guion-Almeida ML
%A Richieri-Costa A
%A Santos JM
%A Kokitsu-Nakata NM
%J J Pediatr Genet
%V 2
%N 4
%D Dec 2013
%M 27625856
暂无%R 10.3233/PGE-13066
%X The authors describe the clinical findings of 38 children with congenital anomalies and misoprostol intrauterine exposure. This study included 38 cases, ascertained from case series of the Hospital of Rehabilitation of Craniofacial Anomalies from University of São Paulo, with evidence of intrauterine exposure to misoprostol in the first trimester of the pregnancy. Information about misoprostol intake and drug administration route was obtained through interviews with mothers. Clinical evaluation showed 18 individuals with facial phenotype compatible with Moebius syndrome; 11 individuals with multiple congenital anomalies; and nine individuals with nonsyndromic cleft lip and/or cleft palate. This study showed a widening of the phenotypic spectrum associated with misoprostol embryotoxicity.