■原发性胆汁性胆管炎(PBC)患者的精神困扰和健康相关生活质量(HrQoL)发生率明显高于普通人群。鉴于证据有限,但是很高的需求,我们的主要目标是评估12周的可行性和可接受性,在线,PBC人群的身心健康计划。
■这是一个单一的群体,顺序混合方法,pre-post可行性,和可接受性研究。核心程序组件包括后续运动,冥想和呼吸视频,和认知行为治疗知情活动。这是由每周电话检查补充。通过招聘评估可行性,坚持,和保留。探索性疗效评估前包括疲劳调查,感知压力,焦虑,抑郁症,HrQoL,和韧性。采用半结构化访谈的定性描述性方法评估了研究经验。
■在30天内招募了32名参与者,其中29名(91%)保留到研究结束。其中,25(86%)坚持每周至少2-3天进行身心练习。反馈支持可接受性(满意度得分90%)。在疲劳方面观察到显著改善(13%,p=0.004),焦虑(30%,p=0.005),抑郁症(28%,p=0.004),和五个PBC-40结构域(瘙痒,疲劳,认知,情感,一般症状)。定性访谈揭示了改善的压力管理,更好的应对,更积极的心态。疲劳和自我破坏的思想被认为是参与的障碍。
■这些研究结果表明,对PBC患者进行为期12周的在线身心干预是可行且可接受的。迭代细化后,将使用该反馈设计一项随机对照试验.
UNASSIGNED: Persons with primary biliary cholangitis (PBC) experience significantly higher rates of mental distress and impaired health related quality of life (HrQoL) than the general population. Given limited evidence, but a high need, our primary aim was to assess feasibility and acceptability of a 12-week, online, mind-body wellness program in people with PBC.
UNASSIGNED: This was a single-group, sequential mixed-methods, pre-post feasibility, and acceptability study. Core program components included follow-along movement, meditation and breathwork videos, and cognitive behavioural therapy informed activities. This was supplemented by weekly phone check-ins. Feasibility was assessed by recruitment, adherence, and retention. The pre-post exploratory efficacy assessment included surveys for fatigue, perceived stress, anxiety, depression, HrQoL, and resilience. A qualitative descriptive approach with semi-structured interviews evaluated study experiences.
UNASSIGNED: Thirty-two participants were recruited within 30 days and 29 (91%) were retained to end-of-study. Of these, 25 (86%) adhered to carrying out the mind-body practice at least 2-3 days per week. Feedback supported acceptability (satisfaction score 90%). Significant improvements were observed in fatigue (13%, p = 0.004), anxiety (30%, p = 0.005), depression (28%, p = 0.004), and five PBC-40 domains (itch, fatigue, cognitive, emotional, general symptoms). Qualitative interviews revealed improved stress management, better coping, and a more positive mindset. Fatigue and self-sabotaging thoughts were cited as barriers to participation.
UNASSIGNED: These findings suggest that a 12-week online mind-body intervention is feasible and acceptable in patients with PBC. After iterative refinement, a randomized controlled trial will be designed using this feedback.