PDF(Pubmed)
Abstract：
BACKGROUND: With an increasing proportion of older adults and the associated risk of Alzheimer\'s Disease and Related Dementias (ADRD) around the globe, there is an urgent need to engage in ADRD risk reduction efforts. African American (AA) older adults in the U.S. are disproportionally impacted by ADRD compared to other races and ethnicities. Mindful walking integrates two potentially protective factors of ADRD by elevating mindfulness and physical activity (i.e., walking), resulting in a synergistic behavioral strategy that is feasible and safe for older adults. However, the efficacy of applying this intervention for cognitive health outcomes has not been evaluated using experimental designs.
METHODS: This paper documents the goal and protocol of a community-based, mindful walking randomized controlled trial to examine the short- and longer-term efficacy on cognitive and other health-related outcomes in ADRD at-risk AA older adults. The study outcomes include various brain health determinants, including cognitive function, quality of life, psychological well-being, physical activity, mindfulness, sleep, and overall health status. In addition, the estimated costs of program implementation are also collected throughout the study period. This study will recruit 114 older adults (ages 60+ years) with elevated ADRD risk from the Midlands region of South Carolina. Older adults are randomly assigned to participate in 24 sessions of outdoor mindful walking over three months or a delayed mindful walking group (n=57 in each group). Participants in both groups follow identical measurement protocols at baseline, after 12 weeks, after 18 weeks, and after 24 weeks from baseline. The outcome measures are administered in the lab and in everyday settings. Costs per participant are calculated using micro-costing methods. The eliciting participant costs for mindful walking engagement with expected results are reported using the payer and the societal perspectives.
CONCLUSIONS: This study will generate evidence regarding the efficacy of mindful walking on sustaining cognitive health in vulnerable older adults. The results can inform future large-scale effectiveness trials to support our study findings. If successful, this mindful walking program can be scaled up as a low-cost and viable lifestyle strategy to promote healthy cognitive aging in diverse older adult populations, including those at greatest risk.
BACKGROUND: ClinicalTrials.gov number NCT06085196 (retrospectively registered on 10/08/2023).
METHODS: This paper documents the goal and protocol of a community-based, mindful walking randomized controlled trial to examine the short- and longer-term efficacy on cognitive and other health-related outcomes in ADRD at-risk AA older adults. The study outcomes include various brain health determinants, including cognitive function, quality of life, psychological well-being, physical activity, mindfulness, sleep, and overall health status. In addition, the estimated costs of program implementation are also collected throughout the study period. This study will recruit 114 older adults (ages 60+ years) with elevated ADRD risk from the Midlands region of South Carolina. Older adults are randomly assigned to participate in 24 sessions of outdoor mindful walking over three months or a delayed mindful walking group (n=57 in each group). Participants in both groups follow identical measurement protocols at baseline, after 12 weeks, after 18 weeks, and after 24 weeks from baseline. The outcome measures are administered in the lab and in everyday settings. Costs per participant are calculated using micro-costing methods. The eliciting participant costs for mindful walking engagement with expected results are reported using the payer and the societal perspectives.
CONCLUSIONS: This study will generate evidence regarding the efficacy of mindful walking on sustaining cognitive health in vulnerable older adults. The results can inform future large-scale effectiveness trials to support our study findings. If successful, this mindful walking program can be scaled up as a low-cost and viable lifestyle strategy to promote healthy cognitive aging in diverse older adult populations, including those at greatest risk.
BACKGROUND: ClinicalTrials.gov number NCT06085196 (retrospectively registered on 10/08/2023).
摘要：
背景：随着全球老年人比例的增加以及阿尔茨海默病和相关痴呆（ADRD）的相关风险，迫切需要参与ADRD降低风险的工作。与其他种族和种族相比，美国的非洲裔美国人（AA）老年人受到ADRD的影响不成比例。正念步行通过提高正念和身体活动来整合ADRD的两个潜在保护因素(即，步行)，产生了一种对老年人可行和安全的协同行为策略。然而,尚未使用实验设计评估这种干预措施对认知健康结局的有效性.
方法：本文记录了基于社区的目标和协议，正念步行随机对照试验，以研究ADRD高危AA老年人对认知和其他健康相关结局的短期和长期疗效。研究结果包括各种大脑健康决定因素，包括认知功能，生活质量,心理健康，身体活动,正念,睡眠,和整体健康状况。此外,在整个研究期间，还收集了计划实施的估计成本。这项研究将招募114名来自南卡罗来纳州中部地区ADRD风险升高的老年人（60岁以上）。老年人被随机分配参加三个月以上的24次户外正念步行或延迟正念步行组（每组n=57）。两组参与者在基线时遵循相同的测量方案，12周后,18周后,和24周后从基线。结果测量在实验室和日常环境中进行。每个参与者的成本是使用微观成本计算方法计算的。使用付款人和社会观点报告了有意识的步行参与和预期结果的参与者成本。
结论：这项研究将提供有关正念步行对脆弱的老年人维持认知健康的功效的证据。结果可以为未来的大规模有效性试验提供信息，以支持我们的研究结果。如果成功,这种有意识的步行计划可以扩大为一种低成本和可行的生活方式策略，以促进不同老年人群的健康认知衰老，包括那些风险最大的人。
背景：ClinicalTrials.gov编号NCT06085196（回顾性注册于2023年10月08日）。
方法：本文记录了基于社区的目标和协议，正念步行随机对照试验，以研究ADRD高危AA老年人对认知和其他健康相关结局的短期和长期疗效。研究结果包括各种大脑健康决定因素，包括认知功能，生活质量,心理健康，身体活动,正念,睡眠,和整体健康状况。此外,在整个研究期间，还收集了计划实施的估计成本。这项研究将招募114名来自南卡罗来纳州中部地区ADRD风险升高的老年人（60岁以上）。老年人被随机分配参加三个月以上的24次户外正念步行或延迟正念步行组（每组n=57）。两组参与者在基线时遵循相同的测量方案，12周后,18周后,和24周后从基线。结果测量在实验室和日常环境中进行。每个参与者的成本是使用微观成本计算方法计算的。使用付款人和社会观点报告了有意识的步行参与和预期结果的参与者成本。
结论：这项研究将提供有关正念步行对脆弱的老年人维持认知健康的功效的证据。结果可以为未来的大规模有效性试验提供信息，以支持我们的研究结果。如果成功,这种有意识的步行计划可以扩大为一种低成本和可行的生活方式策略，以促进不同老年人群的健康认知衰老，包括那些风险最大的人。
背景：ClinicalTrials.gov编号NCT06085196（回顾性注册于2023年10月08日）。
