Intermittent catheterization (IC) utilizing conventional eyelets catheters (CECs) for bladder drainage has long been the standard of care. However, when the tissue of the lower urinary tract comes in close proximity to the eyelets, mucosal suction often occurs, resulting in microtrauma. This study investigates the impact of replacing conventional eyelets with a drainage zone featuring multiple micro-holes, distributing pressure over a larger area. Lower pressures limit the suction of surrounding tissue into these micro-holes, significantly reducing tissue microtrauma. Using an ex vivo model replicating the intra-abdominal pressure conditions of the bladder, the intra-catheter pressure was measured during drainage. When mucosal suction occurred, intra-catheter images were recorded. Subsequently affected tissue samples were investigated histologically. The negative pressure peaks caused by mucosal suction were found to be very high for the CECs, leading to exfoliation of the bladder urothelium and breakage of the urothelial barrier. However, a micro-hole zone catheter (MHZC) with a multi-eyelet drainage zone showed significantly lower pressure peaks, with over 4 times lower peak intensity, thus inducing far less extensive microtraumas. Limiting or even eliminating mucosal suction and resulting tissue microtrauma may contribute to safer catheterizations in vivo and increased patient comfort and compliance.

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UNASSIGNED: Carpal tunnel syndrome (CTS) is the most common type of entrapment neuropathy caused by compression of the median nerve in the carpal tunnel. Epilepsy is characterised by recurrent seizures caused by abnormal neuronal discharges in the brain.This study aimed to investigate whether there is a link between epilepsy and carpal tunnel and, if so, the underlying factors.
UNASSIGNED: Two hundred patients with epilepsy were included in this study. The patients\' history of epilepsy, seizure type, and seizure frequency were assessed. The Tinel, Phalen, and Flick physical examination tests were performed on patients with complaints that matched those of median nerve neuropathy. Patients with epilepsy and clinically diagnosed carpal tunnel syndrome completed the Boston Carpal Tunnel Syndrome Questionnaire, and nerve conduction studies were performed. The relationship between seizure type and frequency in patients with carpal tunnel syndrome was compared.
UNASSIGNED: Compared to focal-aware motor-onset seizures, the risk of detecting carpal tunnel syndrome was 88.7 times higher in focal-onset bilateral tonic-clonic seizures. Patients with a seizure frequency of one per month or more had a 0.704 times lower risk of CTS than those with a frequency of one per week or more (p = 0.026).
UNASSIGNED: Patients with epilepsy, especially those experiencing frequent seizures or specific seizure types, may be more susceptible to repetitive wrist flexion-extension postures. Therefore, during clinical follow-up, it is important to inquire about the presence of carpal tunnel syndrome in patients with epilepsy.

This study aimed to mimic the changes from Charcot neuropathic arthropathy in humans by examining the effects of exposing diet-induced obese (DIO) mice to neurotrauma through a regimented running protocol.
Forty-eight male wild-type C57BL/6J mice were obtained at age 6 weeks and separated into 2 groups for diet assignment. After a 1-week acclimation period, half of the mice consumed a high-fat diet (60% fat by kcal) ad libitum to facilitate neuropathic diet-induced obesity whereas the other half were control mice and consumed an age-matched standard low-fat control diet (10% fat by kcal). At age 12 weeks, half of the animals from each group were subjected to a high-intensity inclined treadmill running protocol, which has been previously demonstrated to induce neurotrauma. Sensory testing and radiographic analyses were periodically performed. Histopathologic analyses were performed post killing.
DIO mice had significantly higher bodyweights, higher body fat percentages, and lower bone mineral density than wildtype control mice that were fed a normal diet throughout the experiment (P < .001 for each). DIO mice displayed significantly reduced sensory function in week 1 (P = .005) and this worsened over time, requiring 20.6% more force for paw withdrawal by week 10 (P < .001). DIO mice that ran demonstrated greater midfoot subluxation and tarsal instability over all time points compared with normal-diet mice that ran (P < .001). Histopathologic analyses revealed that DIO mice that ran demonstrated significant changes compared with controls that ran (P < .001 for each parameter).
Changes akin to the earliest changes observed in or before joint destruction identified in diabetic Charcot neuropathic arthropathy in humans were observed.
There is currently no standard of treatment for patients with Charcot neuropathic arthropathy. This study establishes a protocol for an animal model that can be used to study and compare interventions to treat this disease.

UNASSIGNED: Sports injuries occur during sport athletic activities, or exercising. However, there are some lesions which are typically associated to sports, in such a demanding and physical sport like Muay Thai that no typical lesion has been detected yet. We performed a narrative review of the literature to highlight the typical lesions of this sport to analyze the differential diagnosis of those conditions.
UNASSIGNED: A 28-year-old female, Muay Thai athlete since 16 years, presented with a 6 months history of a persistent pain in the metaphyseal lateral part of the right tibia. Differentiation between stress injuries, malignant bone tumors, and tumor-like lesions after repetitive microtrauma following sport activities can be difficult. The diagnostic approach involved conventional X-ray, echotomography, computed tomography scan, and magnetic resonance imaging scan with controversial findings. The biopsy confirmed the final diagnosis of non-ossifying fibroma.
UNASSIGNED: The purpose of this case report is to exhibit the challenges in the diagnosis of a professional Muay Thai athlete with tibial pain and to discuss the clinical presentation of this type of patients with a limited population in the literature. Our case illustrates that even modern imaging techniques cannot always distinguish between tumor and tumor-like lesions caused by sports; meanwhile remembered us that we should never be too focused on a particular characteristic forgetting even rare pathologies as adamantinoma.

Plexiform neurofibroma is a rare benign tumor and a special subtype of neurofibromatosis 1. This report is a literature review with a case of patient with facial hemorrhage observed at the site of neurofibroma removal in the right lower face due to minor trauma. Through PubMed search, using terms ((facial hematoma) OR (facial bleeding)) AND (neurofibromatosis), 86 articles were identified, and five related articles (six patients) were finally selected. Of the six patients, two had previously undergone embolization. However, as a result, all patients received open surgery to remove hematomas. The hemostatic methods mentioned were vascular ligation (five patients), hypotensive anesthesia (two patients), and postoperative blood transfusion (four patients). In conclusion, spontaneous or minimally traumatic bleeding is possible in neurofibromatosis patients. In most cases, it can be resolved by vascular ligation under hypotensive anesthesia. Optionally, prior embolization and supplementary tissue adhesive may be used.

Osteochondral lesions of the talus (OLTs) are lesions that occur before the physis closes and are frequently associated with acute ankle trauma. These lesions are often difficult to diagnose due to swelling and inflammation that are present after the initial injury. A growing body of literature has assessed the effects of OLTs in the adult population. However, the literature examining these lesions in the juvenile population is sparse. The purpose of this review is to provide a thorough understanding of OLTs, with a specific focus on the juvenile population. We evaluate the recent literature regarding the outcomes of various surgical treatment; modalities in the pediatric patient. While the outcomes after surgical treatment of pediatric OLTs are generally favorable, the paucity of investigation in this demographic is alarming. Further research is needed to better inform practitioners and families regarding these outcomes, as treatment plans are highly dependent on the individual patient in question.

OBJECTIVE: To evaluate the effect of micro-osteoperforations (MOPs) on the rate of orthodontic tooth movement (OTM) during en masse anterior retraction.
METHODS: Twenty patients were randomly allocated into experimental and control group of 10 each. In the control group, en masse retraction was performed with sliding mechanics with a coil spring. In the experimental group after alignment and levelling, MOPs were performed mesially and distally to all six anterior teeth in the interdental cortical region on the labial aspect of both arches. MOPs were performed at the beginning of space closure (T0) and 1 month after beginning of space closure (T1). En masse retraction was performed with sliding mechanics with a coil spring. Measurements were recorded on digital models made from scanned plaster casts at the beginning of space closure (T0) and monthly at each follow-up visit for the next 4 months (T1, T2, T3, T4). The monthly rate of OTM, the overall rate of OTM, and the difference between OTM in the MOP period (T0-T2) and post-MOP (T2-T4) period in the experimental and control group were evaluated. A visual analogue scale (VAS) was used to evaluate patients\' pain experience.
RESULTS: The overall rate of OTM was significantly greater in the experimental group for both arches in the MOP period (T0-T2) and also in the post-MOP period (T2-T4) as compared to the control group. Within the experimental group, the rate of OTM in the MOP period was significantly greater than in the post-MOP period, which in turn was greater than that of the control group. The patients reported only mild discomfort for 24 h after performing the MOPs, which then gradually decreased.
CONCLUSIONS: The use of MOPs is effective in increasing the rate of en masse tooth retraction in both the maxillary and the mandibular arch. The rate of tooth movement was greater even in the post-MOP period as compared to the control group.
UNASSIGNED: ZIELSETZUNG: Untersucht werden sollten die Auswirkungen von Mikro-Osteoperforationen (MOPs) auf die Geschwindigkeit der kieferorthopädischen Zahnbewegung (OTM) während einer En-masse-Retraktion im Frontzahnbereich.
METHODS: Zwanzig Patienten wurden randomisiert in eine Versuchs- und eine Kontrollgruppe mit jeweils 10 Patienten eingeteilt. In der Kontrollgruppe wurde die En-masse-Retraktion mit einer Gleitmechanik und einer Zugfeder durchgeführt. In der Versuchsgruppe wurden nach der Ausrichtung und Nivellierung MOPs mesial und distal an allen 6 Frontzähnen in der interdentalen Kortikalregion auf der labialen Seite beider Zahnbögen durchgeführt. Die MOPs wurden zu Beginn des Lückenschlusses (T0) und einen Monat nach Beginn des Lückenschlusses (T1) durchgeführt. Die En-masse-Retraktion wurde mit einer Gleitmechanik und einer Zugfeder durchgeführt. Die Messungen wurden auf digitalen Modellen aufgezeichnet, die aus eingescannten Gipsabdrücken zu Beginn des Lückenschlusses (T0) und monatlich bei jeder Nachuntersuchung in den nächsten 4 Monaten (T1, T2, T3, T4) erstellt wurden. Die monatliche OTM-Rate, die Gesamtrate der OTM und der Unterschied zwischen der OTM in der MOP-Periode (T0-T2) und in der Post-MOP-Periode (T2-T4) in der Versuchs- und in der Kontrollgruppe wurden bewertet. Zur Einschätzung des Schmerzempfindens der Patienten wurde eine visuelle Analogskala (VAS) verwendet.
UNASSIGNED: Die Gesamtrate der OTM war in der Versuchsgruppe für beide Zahnbögen in der MOP-Periode (T0-T2) und auch in der Post-MOP-Periode (T2-T4) im Vergleich zur Kontrollgruppe signifikant höher. In der Versuchsgruppe war die OTM-Rate in der MOP-Periode signifikant höher als in der Post-MOP-Periode, die wiederum höher war als die der Kontrollgruppe. Die Patienten berichteten über 24 h lang nach Durchführung der MOP andauernde, nur geringe, dann allmählich abnehmende Beschwerden.
UNASSIGNED: Die Anwendung von MOPs ist effektiv, um die Geschwindigkeit einer En-masse-Retraktion von Zähnen sowohl im Ober- als auch im Unterkiefer zu erhöhen. Die Geschwindigkeit der Zahnbewegung war sogar in der Zeit nach der MOP höher als in der Kontrollgruppe.

OBJECTIVE: Congenital malalignment of the great toenail (CMGT) is an idiopathic deviation of the nail apparatus. CMGT predisposes patients to recurrent stress forces, microtrauma, and secondary complications. The purpose of this study was to review the current published photographs to determine the relationship between variants of CMGT and the disappearing nail bed (DNB).
METHODS: A search in PubMed and Google using the terms congenital malalignment of the great toenail, disappearing nail bed, and lateral nail deviation was performed. Of the 53 photographs found in a total of 35 articles, 23 were disqualified due to low picture resolution or poor angle. The remaining 30 photographs were evaluated. Pure nail malalignment with associated dystrophy and DNB was found in 22 of 30 photographs. Four of 30 cases demonstrated pure deviation of the distal phalanx, with nail dystrophy but minimal DNB. The remaining 4 cases demonstrated a combination of toe deviation and nail unit deviation with varying degrees of DNB.
CONCLUSIONS: DNB was associated with all forms of pure CMGT. Moreover, a variant of malalignment of the distal phalanx was noted in 8 photographs. This has potential implications for further studies and treatment to correct secondary complications.